Search Results - "Rait, Antonina"

Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors by Senzer, Neil, Nemunaitis, John, Nemunaitis, Derek, Bedell, Cynthia, Edelman, Gerald, Barve, Minal, Nunan, Robert, Pirollo, Kathleen F, Rait, Antonina, Chang, Esther H

“…Selective delivery of therapeutic molecules to primary and metastatic tumors is optimal for effective cancer therapy. A liposomal nanodelivery complex (scL)…”
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A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate by Pirollo, Kathleen F, Moghe, Manish, Guan, Miaoyin, Rait, Antonina S, Wang, Aibing, Kim, Sang-Soo, Chang, Esther H, Harford, Joe B

“…Organophosphates are among the deadliest of known chemicals based on their ability to inactivate acetylcholinesterase in neuromuscular junctions and synapses…”
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Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer by Saleh, Anthony D, Cheng, Hui, Martin, Scott E, Si, Han, Ormanoglu, Pinar, Carlson, Sophie, Clavijo, Paul E, Yang, Xinping, Das, Rita, Cornelius, Shaleeka, Couper, Jamie, Chepeha, Douglas, Danilova, Ludmila, Harris, Thomas M, Prystowsky, Michael B, Childs, Geoffrey J, Smith, Richard V, Robertson, A Gordon, Jones, Steven J M, Cherniack, Andrew D, Kim, Sang S, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H, Chen, Zhong, Van Waes, Carter

“…To identify deregulated and inhibitory miRNAs and generate novel mimics for replacement nanomedicine for head and neck squamous cell carcinomas (HNSCC). We…”
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scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate by Moghe, Manish, Kim, Sang-Soo, Guan, Miaoyin, Rait, Antonina, Pirollo, Kathleen F, Harford, Joe B, Chang, Esther H

“…Due to their inhibition of acetylcholinesterase, organophosphates are among the most toxic of chemicals. Pralidoxime (a.k.a 2-PAM) is the only…”
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Combination with SGT-53 overcomes tumor resistance to a checkpoint inhibitor by Kim, Sang-Soo, Harford, Joe B., Moghe, Manish, Rait, Antonina, Chang, Esther H.

“…The tumor suppressor p53 responds to genotoxic and oncogenic stresses by inducing cell cycle arrest and apoptosis. Recent studies suggest that p53 also…”
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Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53‐altered tumors by Gunaratne, Preethi H., Pan, Yinghong, Rao, Abhi K., Lin, Chunru, Hernandez‐Herrera, Anadulce, Liang, Ke, Rait, Antonina S., Venkatanarayan, Avinashnarayan, Benham, Ashley L., Rubab, Farwah, Kim, Sang Soo, Rajapakshe, Kimal, Chan, Clara K., Mangala, Lingegowda S., Lopez‐Berestein, Gabriel, Sood, Anil K., Rowat, Amy C., Coarfa, Cristian, Pirollo, Kathleen F., Flores, Elsa R., Chang, Esther H.

“…Background Over 96% of high‐grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore…”
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The Clinical Potential of Targeted Nanomedicine: Delivering to Cancer Stem-like Cells by Kim, Sang-Soo, Rait, Antonina, Rubab, Farwah, Rao, Abhi K, Kiritsy, Michael C, Pirollo, Kathleen F, Wang, Shangzi, Weiner, Louis M, Chang, Esther H

“…Cancer stem-like cells (CSCs) have been implicated in recurrence and treatment resistance in many human cancers. Thus, a CSC-targeted drug delivery strategy to…”
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Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system by PIROLLO, Kathleen F, RAIT, Antonina, QI ZHOU, SUNG HEE HWANG, DAGATA, John A, ZON, Gerald, HOGREFE, Richard I, PALCHIK, Guillermo, CHANG, Esther H

“…The field of small interfering RNA (siRNA) as potent sequence-selective inhibitors of transcription is rapidly developing. However, until now, low transfection…”
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A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme by Kim, Sang-Soo, PhD, Rait, Antonina, PhD, Kim, Eric, BSc, Pirollo, Kathleen F., PhD, Chang, Esther H., PhD

“…Abstract Development of temozolomide (TMZ) resistance contributes to the poor prognosis for glioblastoma multiforme (GBM) patients. It was previously…”
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Tumor-Targeting Nanocomplex Delivery of Novel Tumor Suppressor RB94 Chemosensitizes Bladder Carcinoma Cells In vitro and In vivo by Pirollo, Kathleen F, Rait, Antonina, Zhou, Qi, Zhang, Xin-qiao, Zhou, Jain, Kim, Chang-Soo, Benedict, William F, Chang, Esther H

“…Purpose: RB94, a truncated form of RB110, has enhanced tumor suppressor potency and activity against all tumor types tested to date including bladder…”
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Antisense oligonucleotides targeted to the human α folate receptor inhibit breast cancer cell growth and sensitize the cells to doxorubicin treatment by Jhaveri, Mona S, Rait, Antonina S, Chung, Koong-Nah, Trepel, Jane B, Chang, Esther H

“…Folates are essential for cell survival and are required for numerous biochemical processes. The human α isoform folate receptor (αhFR) has a very high…”
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Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo by Yang, Chengli, PhD, Rait, Antonina, PhD, Pirollo, Kathleen F., PhD, Dagata, John A., PhD, Farkas, Natalia, PhD, Chang, Esther H., PhD

“…Abstract To circumvent the problem of reduction of the supermagnetic properties of superparamagnetic iron oxide (SPIO) nanoparticles after chemical…”
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Antisense therapeutics: from theory to clinical practice by Pirollo, Kathleen F, Rait, Antonina, Sleer, Leanne S, Chang, Esther H

“…The use of antisense (AS) oligonucleotides as therapeutic agents was proposed as far back as the 1960s/1970s when the AS strategy was initially developed…”
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Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue by Hwang, Sung Hee, Rait, Antonina, Pirollo, Kathleen F, Zhou, Qi, Yenugonda, Venkata Mahidhar, Chinigo, Gary M, Brown, Milton L, Chang, Esther H

“…GMC-5-193 (GMC) is a novel anticancer small-molecule quinazolinone analogue with properties that include antimicrotubule activity and inherent fluorescence…”
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Tumor-targeting, systemically delivered antisense HER-2 chemosensitizes human breast cancer xenografts irrespective of HER-2 levels by Rait, Antonina S, Pirollo, Kathleen F, Xiang, Laiman, Ulick, David, Chang, Esther H

“…The failure to respond to chemotherapy is a major obstacle in the successful treatment of breast cancer. We have previously shown that anti-HER-2 antisense…”
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HER-2-Targeted Antisense Oligonucleotide Results in Sensitization of Head and Neck Cancer Cells to Chemotherapeutic Agents by RAIT, ANTONINA S., PIROLLO, KATHLEEN F., ULICK, DAVID, CULLEN, KEVIN, CHANG, ESTHER H.

“…: Existing HER‐2 targeted therapies for human head and neck cancers, usually administered in combination with chemotherapeutic drugs or irradiation, include…”
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p53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy by PIROLLO, K. F, HAO, Z, RAIT, A, JANG, Y.-J, FEE, W. E, RYAN, P, CHIANG, Y, CHANG, E. H

“…Radiation resistant squamous cell carcinoma of the head and neck cell line JSQ-3 carries a mutant form of tumor suppressor gene p53. Treatment of these cells…”
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Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide by Kim, Sang-Soo, Harford, Joe B, Moghe, Manish, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H

“…Abstract Intrinsic therapeutic resistance especially in cancer stem cells (CSCs) together with extensive tumor cell infiltration and restricted permeation of…”
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Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma by Kim, Sang-Soo, Rait, Antonina, Kim, Eric, DeMarco, James, Pirollo, Kathleen F, Chang, Esther H

“…Highlights • GBM is the most aggressive and lethal type of brain tumor with a poor prognosis. • Novel strategies are needed to improve limited efficacy of TMZ…”
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Downmodulation of bFGF-binding protein expression following restoration of p53 function by Sherif, Z A, Nakai, S, Pirollo, K F, Rait, A, Chang, E H

“…Angiogenesis is a requirement for solid tumor growth. Therefore, inhibition of this neovascularization is one mechanism by which restoration of wtp53 function…”
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