Search Results - "Raisz, L. G"

Pathogenesis of osteoporosis: concepts, conflicts, and prospects by Raisz, Lawrence G

“…Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This review examines the fundamental pathogenetic mechanisms underlying…”
Get full text

Physiology and Pathophysiology of Bone Remodeling by Raisz, Lawrence G

“…The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. This remodeling is necessary both to maintain the structural…”
Get full text

Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels by Kenny, A M, Prestwood, K M, Gruman, C A, Marcello, K M, Raisz, L G

“…A large proportion of men over 65 years of age have bioavailable testosterone levels below the reference range of young adult men. The impact of this on…”
Get full text

Fractures Attributable to Osteoporosis: Report from the National Osteoporosis Foundation by Melton, L. J., Thamer, M., Ray, N. F., Chan, J. K., Chesnut, C. H., Einhorn, T. A., Johnston, C. C., Raisz, L. G., Silverman, S. L., Siris, E. S.

“…To assess the cost‐effectiveness of interventions to prevent osteoporosis, it is necessary to estimate total health care expenditures for the treatment of…”
Get full text

Femoral bone mineral density in patients with heart failure by KENNY, A. M, BOXER, R, WALSH, S, HAGER, W. D, RAISZ, L. G

“…Heart failure and osteoporosis are common conditions in older, frail individuals. It is important to investigate interactions of the common problems in the…”
Get full text

Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study by Taxel, P., Kaneko, H., Lee, S.-K., Aguila, H. L., Raisz, L. G., Lorenzo, J. A.

“…Summary We examined RANKL expression and OCL formation in cultured bone marrow cells from eight postmenopausal women in response to E 2 . E 2 treatment…”
Get full text

Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women by RAISZ, L. G, WIITA, B, ARTIS, A, BOWEN, A, SCHWARTZ, S, TRAHIOTIS, M, SHOUKRI, K, SMITH, J

“…The present study was undertaken to determine whether the addition of an androgen to estrogen therapy in postmenopausal women would alter the skeletal response…”
Get full text

Importance of bone mineral density measurements in evaluating fragility bone fracture risk in Asian Indian men by Kuruvilla, K, Kenny, A. M, Raisz, L. G, Kerstetter, J. E, Feinn, R. S, Rajan, T. V

“…Summary We evaluated the effect of BMD on fracture risk prediction using FRAX® among Asian Indian men when used in conjunction with clinical risk factors. A…”
Get full text

Prostaglandins and bone: physiology and pathophysiology by Raisz, L.G.

“…Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully…”
Get full text

Causes of Age‐Related Bone Loss and Bone Fragility: An Alternative View by Raisz, Lawrence G., Seeman, Ego

Get full text

The role of prostaglandins in the regulation of bone metabolism by Kawaguchi, H, Pilbeam, C C, Harrison, J R, Raisz, L G

“…Prostaglandins are likely to play an important role in the physiologic and pathologic responses of skeletal tissue. They are potent agonists that can stimulate…”
Get more information

How basic science informed the Delmas clinical approach by Martin, T. J, Raisz, L. G

“…Pierre Delmas has been a dominant figure for decades in clinical research in osteoporosis, with major contributions also in arthritis and the skeletal…”
Get full text

Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice by LI, X, PILBEAM, C. C, PAN, L, BREYER, R. M, RAISZ, L. G

“…Recent studies have shown that stimulation of osteoclastogenesis in cocultures of osteoblasts and spleen cells in response to prostaglandin E2 (PGE2) is…”
Get full text

Basic Fibroblast Growth Factor Induces Osteoclast Formation in Murine Bone Marrow Cultures by Hurley, M.M, Lee, S.K, Raisz, L.G, Bernecker, P, Lorenzo, J

“…We determined the effect of basic fibroblast growth factor (bFGF) on osteoclast-like cell (OCL) formation in bone marrow cultures using C57BL/6 mice. Cells…”
Get full text

A call to action: developing and implementing a national action plan to improve bone health by Raisz, L. G., Elderkin, A. L., Schargorodski, L., Hart, T., Waldman, C., King, T., Noonan, A. S.

“…Over the past 40 years, there have been important advances in our understanding of bone health and new methods to diagnose, prevent, and treat osteoporosis and…”
Get full text

A comparison of the effects of raloxifene and estrogen on bone in postmenopausal women by PRESTWOOD, K. M, GUNNESS, M, MUCHMORE, D. B, YILI LU, MAYME WONG, RAISZ, L. G

“…Raloxifene HCl, a selective estrogen receptor modulator, has been shown to increase bone mineral density (BMD) and decrease biochemical markers of bone…”
Get full text

Effects of selective prostaglandin EP4 receptor antagonist on osteoclast formation and bone resorption in vitro by TOMITA, M, LI, X, OKADA, Y, WOODIEL, F. N, YOUNG, R. N, PILBEAM, C. C, RAISZ, L. G

“…Prostaglandin estradiol (PGE(2)) stimulates bone resorption by a cyclic AMP (cAMP)-dependent mechanism that involves prostaglandin E receptors of the EP2 and…”
Get full text

Pulsating Fluid Flow Stimulates Prostaglandin Release and Inducible Prostaglandin G/H Synthase mRNA Expression in Primary Mouse Bone Cells by Klein‐Nulend, Jenneke, Burger, Elisabeth H., Semeins, Cornelis M., Raisz, Lawrence G., Pilbeam, Carol C.

“…Bone tissue responds to mechanical stress with adaptive changes in mass and structure. Mechanical stress produces flow of fluid in the osteocyte…”
Get full text

The osteoporosis revolution by RAISZ, L. G

“…Our concepts of the pathogenesis, diagnosis, prevention, and treatment of osteoporosis are radically changing. Some changes, such as the study of genetic…”
Get full text

Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone by Sabbieti, M. G, Marchetti, L, Abreu, C, Montero, A, Hand, A. R, Raisz, L. G, Hurley, M. M

“…We examined the effect of PGs, particularly PGF2α, on basic fibroblast growth factor-2 (FGF-2) messenger RNA (mRNA) and protein in the rat osteoblastic cell…”
Get full text