Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis-associated bone loss: a prospective cohort study

The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies dire...

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Published in:	Journal of bone and mineral metabolism Vol. 34; no. 4; pp. 422 - 428
Main Authors:	Kalantarhormozi, Mohammad Reza, Assadi, Majid, Vahdat, Katayoun, Asadipooya, Kamyar, Ostovar, Afshin, Raissi, Katayoun, Darabi, Hossein, Farrokhi, Shokrollah, Dobaradaran, Sina, Farrokhnia, Maryam, Nabipour, Iraj
Format:	Journal Article
Language:	English
Published:	Tokyo Springer Japan 01-07-2016 Springer Nature B.V
Subjects:	Aged Antibodies, Bacterial - blood Body Mass Index Chlamydophila Infections - blood Chlamydophila Infections - pathology Chlamydophila pneumoniae Female Femur Neck - metabolism Femur Neck - pathology Follow-Up Studies Helicobacter Infections - blood Helicobacter Infections - pathology Helicobacter pylori Humans Immunoglobulin G - blood Lumbosacral Region - pathology Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Article Orthopedics Osteoporosis - blood Osteoporosis - pathology Prospective Studies Spine - metabolism Spine - pathology Osteoporosis Bone mineral density Chlamydia pneumoniae Helicobacter pylori
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Summary:	The potential link between infection with Chlamydia pneumoniae or Helicobacter pylori and osteoporosis has not been investigated in population-based longitudinal studies. A total of 250 healthy postmenopausal women who participated in a prospective cohort study were evaluated for IgG antibodies directed against C. pneumoniae and H. p ylori , osteoprotegerin (OPG), the receptor activator of nuclear factor kappa B ligand (RANKL), CrossLaps, and osteocalcin. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine at baseline and at follow-up 5.8 years later. There were no significant differences in age-adjusted bone turnover markers, OPG, RANKL, the RANKL/OPG ratio, and BMD between the C. p neumoniae and H. p ylori IgG seropositive and seronegative subjects ( P > 0.05). Neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine or bone loss at the 5.8-year follow-up. In logistic regression analysis, neither C. p neumoniae nor H. p ylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. p neumoniae nor H. p ylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss in postmenopausal women. In addition, chronic infection with C. p neumoniae or H. p ylori did not predict incident osteoporosis among this group of women.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0914-8779 1435-5604
DOI:	10.1007/s00774-015-0688-9