Search Results - "Rainier, Jon D."

The Synthesis of Indoline and Benzofuran Scaffolds Using a Suzuki–Miyaura Coupling/Oxidative Cyclization Strategy by Jana, Somnath, Rainier, Jon D

“…The generation of indolines and benzofurans from the combination of Suzuki–Miyaura coupling reactions with oxidative cyclizations is described…”
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Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin by Zhang, Yuan, Rainier, Jon D

“…Yessotoxin and adriatoxin are members of the polycyclic ether family of marine natural products. Outlined in this article is our synthetic approach to two…”
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An Expeditious Synthesis of C(3)−N(1′) Heterodimeric Indolines by Espejo, Vinson R, Rainier, Jon D

“…This paper describes the efficient and relatively simple synthesis of C(3)−N(1′) heterodimeric indolines from the addition of indole nucleophiles to readily…”
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Olefinic Ester and Diene Ring-Closing Metathesis Using a Reduced Titanium Alkylidene by Iyer, Karthik, Rainier, Jon D

“…This manuscript describes the use of a reduced titanium ethylidene reagent in olefinic ester cyclization reactions and diene RCM reactions…”
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ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury by Walder, Roxanne Y, Rasmussen, Lynn A, Rainier, Jon D, Light, Alan R, Wemmie, John A, Sluka, Kathleen A

“…Acid-sensing ion channels (ASICs) respond to acidosis that normally occurs after inflammation. We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in…”
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Highly Diastereoselective Sulfonium Ylide Rearrangements to Quaternary Substituted Indolines by Boyarskikh, Vyacheslav, Nyong, Abijah, Rainier, Jon D

“…Quat. centers: Sulfonium ylide intermediates generated from halogenated vinyl diazoacetates and 2‐thioindoles in the presence of a RhII complex undergo highly…”
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2-Thioindoles as Precursors to Spiro-Fused Indolines: Synthesis of (±)-Dehaloperophoramidine by Sabahi, Amir, Novikov, Alexei, Rainier, Jon D.

“…Closing the ring: The cyclization of a 2‐thioindole with an electrophilic substituent serves as the key transformation in a synthetic strategy for the…”
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The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state by Kopljar, Ivan, Labro, Alain J, de Block, Tessa, Rainier, Jon D, Tytgat, Jan, Snyders, Dirk J

“…Voltage-gated potassium (Kv) and sodium (Nav) channels are key determinants of cellular excitability and serve as targets of neurotoxins. Most marine…”
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Harnessing Glycal-Epoxide Rearrangements: The Generation of the AB, EF, and IJ Rings of Adriatoxin by Osei Akoto, Clement, Rainier, Jon D

“…Climbing the ladder: The generation of three bicyclic subunits of adriatoxin (see structure) was accomplished by using glycal‐epoxide rearrangements,…”
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A gram-scale synthesis of very-long chain polyunsaturated fatty acids (VLC-PUFAs) by Song, Changqing, Wade, Alex, Rainier, Jon D

“…This manuscript describes our third generation, gram-scale synthesis of very long chain-polyunsaturated fatty acids (VLC-PUFAs), a unique and increasingly…”
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Photoelectrocyclization Reactions of Conjugated Cycloalkenones: Scope and Reactivity by Zhao, Xuchen, Song, Changqing, Rainier, Jon D

“…Outlined here are studies exploring the scope of the sequential photoelectrocyclization, [1,5]-hydride shift of conjugated bis-aryl cycloalkenone substrates…”
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A Polyether Biotoxin Binding Site on the Lipid-Exposed Face of the Pore Domain of KV Channels Revealed by the Marine Toxin Gambierol by Kopljar, Ivan, Labro, Alain J., Cuypers, Eva, Johnson, Henry W. B., Rainier, Jon D., Tytgat, Jan, Snyders, Dirk J., Miller, Christopher

“…Gambierol is a marine poly cyclic ether toxin belonging to the group of ciguatera toxins. It does not activate voltage-gated sodium channels (VGSCs) but…”
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Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels by Cuypers, Eva, Abdel-Mottaleb, Yousra, Kopljar, Ivan, Rainier, Jon D., Raes, Adam L., Snyders, Dirk J., Tytgat, Jan

“…In this study, we pharmacologically characterized gambierol, a marine polycyclic ether toxin which is produced by the dinoflagellate Gambierdiscus toxicus…”
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Stereodivergent Photoelectrocyclization Reactions of Bis-aryl Cycloalkenones: Intercepting Photoelectrocyclization Intermediates with Acid by Zhao, Xuchen, Song, Changqing, Rainier, Jon D

“…Described here are tandem photoelectrocyclization and [1,5]-hydride shift reactions of heteroaryl-containing bis-aryl cyclohexenone derivatives that give…”
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Total Synthesis of Gambierol: The Generation of the A-C and F-H Subunits by Using a C-Glycoside Centered Strategy by Majumder, Utpal, Cox, Jason M., Johnson, Henry W. B., Rainier, Jon D.

“…Gambierol, a representative of the marine ladder toxin family, consists of eight ether rings, 18 stereocenters, and two challenging pyranyl rings having methyl…”
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TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning by Cuypers, Eva, Yanagihara, Angel, Rainier, Jon D., Tytgat, Jan

“…Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances,…”
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The Role of N-Substitution in Regio- and Stereoselective Vinylogous Imidonaphthoquinone (VINAquinone) [2 + 2] Photocycloadditions by Merski, Ian, Yin, Jinya, VanderLinden, Ryan T., Rainier, Jon D.

“…Described in this manuscript are intramolecular [2 + 2] photocycloadditions of readily available vinylogous imidonaphthoquinones whose regio- and…”
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Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons by Cao, Zhengyu, George, Joju, Gerwick, William H, Baden, Daniel G, Rainier, Jon D, Murray, Thomas F

“…The electrical signals of neurons are fundamentally dependent on voltage-gated sodium channels (VGSCs), which are responsible for the rising phase of the…”
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Total Synthesis of Gambierol: Subunit Coupling and Completion by Johnson, Henry W. B., Majumder, Utpal, Rainier, Jon D.

“…The preceding manuscript detailed our synthesis of the gambierol A–C and F–H ring precursors. Reported herein is a description of the coupling of the two…”
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The one-pot synthesis of amidonapthoquinones from aminonaphthoquinones by Yin, Jinya, Rainier, Jon D.

“…[Display omitted] •The efficient synthesis of amidonapthoquinones from aminoquinones.•Coupling the one-pot reduction of quinones with amide formation and…”
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