Search Results - "Rainey, William E."

Age-Related Autonomous Aldosteronism by Nanba, Kazutaka, Vaidya, Anand, Williams, Gordon H, Zheng, Isabel, Else, Tobias, Rainey, William E

“…BACKGROUND:Both aging and inappropriate secretion of aldosterone increase the risk for developing cardiovascular disease; however, the influence of aging on…”
Get full text

International Histopathology Consensus for Unilateral Primary Aldosteronism by Williams, Tracy Ann, Gomez-Sanchez, Celso E, Rainey, William E, Giordano, Thomas J, Lam, Alfred K, Marker, Alison, Mete, Ozgur, Yamazaki, Yuto, Zerbini, Maria Claudia Nogueira, Beuschlein, Felix, Satoh, Fumitoshi, Burrello, Jacopo, Schneider, Holger, Lenders, Jacques W M, Mulatero, Paolo, Castellano, Isabella, Knösel, Thomas, Papotti, Mauro, Saeger, Wolfgang, Sasano, Hironobu, Reincke, Martin

“…Abstract Objective Develop a consensus for the nomenclature and definition of adrenal histopathologic features in unilateral primary aldosteronism (PA)…”
Get full text

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans by Nanba, Kazutaka, Omata, Kei, Else, Tobias, Beck, Peter C C, Nanba, Aya T, Turcu, Adina F, Miller, Barbra S, Giordano, Thomas J, Tomlins, Scott A, Rainey, William E

“…Somatic mutations have been identified in more than half of aldosterone-producing adenomas (APAs) through mutation hotspot sequencing. The underlying…”
Get full text

11-Ketotestosterone Is the Dominant Circulating Bioactive Androgen During Normal and Premature Adrenarche by Rege, Juilee, Turcu, Adina F, Kasa-Vubu, Josephine Z, Lerario, Antonio M, Auchus, Gabriela C, Auchus, Richard J, Smith, Joshua M, White, Perrin C, Rainey, William E

“…Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S) associated with the development of a functional adrenal zona reticularis. Clinical…”
Get full text

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism by Omata, Kei, Satoh, Fumitoshi, Morimoto, Ryo, Ito, Sadayoshi, Yamazaki, Yuto, Nakamura, Yasuhiro, Anand, Sharath K, Guo, Zeng, Stowasser, Michael, Sasano, Hironobu, Tomlins, Scott A, Rainey, William E

“…Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral and bilateral forms. Most unilateral primary aldosteronism is caused by…”
Get full text

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands by Nishimoto, Koshiro, Tomlins, Scott A., Kuick, Rork, Cani, Andi K., Giordano, Thomas J., Hovelson, Daniel H., Liu, Chia-Jen, Sanjanwala, Aalok R., Edwards, Michael A., Gomez-Sanchez, Celso E., Nanba, Kazutaka, Rainey, William E.

“…Primary aldosteronism (PA) represents the most common cause of secondary hypertension, but little is known regarding its adrenal cellular origins. Recently,…”
Get full text

Sex Differences in 11-Oxygenated Androgen Patterns Across Adulthood by Davio, Angela, Woolcock, Helen, Nanba, Aya T, Rege, Juilee, O’Day, Patrick, Ren, Jianwei, Zhao, Lili, Ebina, Hiroki, Auchus, Richard, Rainey, William E, Turcu, Adina F

“…Abstract Context The gonads are the major source of sex steroids during reproductive ages. The gonadal function declines abruptly in women and gradually in…”
Get full text

Acute and chronic regulation of aldosterone production by Hattangady, Namita G., Olala, Lawrence O., Bollag, Wendy B., Rainey, William E.

“…► Aldosterone is the major mineralocorticoid produced by the adrenal zona glomerulosa. ► Glomerulosa cells are primarily regulated by angiotensin II, serum…”
Get full text

Three Discrete Patterns of Primary Aldosteronism Lateralization in Response to Cosyntropin during Adrenal Vein Sampling by Wannachalee, Taweesak, Zhao, Lili, Nanba, Kazutaka, Nanba, Aya T, Shields, James J, Rainey, William E, Auchus, Richard J, Turcu, Adina F

“…Cosyntropin [ACTH (1-24)] stimulation during adrenal vein (AV) sampling (AVS) enhances the confidence in the success of AV cannulation and circumvents…”
Get full text

Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients by Nanba, Kazutaka, Yamazaki, Yuto, Bick, Nolan, Onodera, Kei, Tezuka, Yuta, Omata, Kei, Ono, Yoshikiyo, Blinder, Amy R, Tomlins, Scott A, Rainey, William E, Satoh, Fumitoshi, Sasano, Hironobu

“…Abstract Context Results of previous studies demonstrated clear racial differences in the prevalence of somatic mutations among patients with…”
Get full text

The steroid metabolome of adrenarche by Rege, Juilee, Rainey, William E

“…Adrenarche is an endocrine developmental process whereby humans and select nonhuman primates increase adrenal output of a series of steroids, especially DHEA…”
Get full text

Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks by Nanba, Kazutaka, Omata, Kei, Gomez-Sanchez, Celso E, Stratakis, Constantine A, Demidowich, Andrew P, Suzuki, Mari, Thompson, Lester D R, Cohen, Debbie L, Luther, James M, Gellert, Lan, Vaidya, Anand, Barletta, Justine A, Else, Tobias, Giordano, Thomas J, Tomlins, Scott A, Rainey, William E

“…Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent…”
Get full text

Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency by Turcu, Adina F, Nanba, Aya T, Chomic, Robert, Upadhyay, Sunil K, Giordano, Thomas J, Shields, James J, Merke, Deborah P, Rainey, William E, Auchus, Richard J

“…Abstract Objective To comprehensively characterize androgens and androgen precursors in classic 21-hydroxylase deficiency (21OHD) and to gain insights into the…”
Get full text

Histopathological classification of cross-sectional image negative hyperaldosteronism by Yamazaki, Yuto, Nakamura, Yasuhiro, Omata, Kei, Ise, Kazue, Tezuka, Yuta, Ono, Yoshikiyo, Morimoto, Ryo, Nozawa, Yukinaga, Gomez-Sanchez, Celso E, Tomlins, Scott A, Rainey, William E, Ito, Sadayoshi, Satoh, Fumitoshi, Sasano, Hironobu

“…Context:Approximately half of primary aldosteronism (PA) have clinically evident disease according to clinical (hypertension) and/or laboratory (aldosterone…”
Get full text

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Human Adrenal Vein 19-Carbon Steroids Before and After ACTH Stimulation by Rege, Juilee, Nakamura, Yasuhiro, Satoh, Fumitoshi, Morimoto, Ryo, Kennedy, Michael R, Layman, Lawrence C, Honma, Seijiro, Sasano, Hironobu, Rainey, William E

“…Context: A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid…”
Get full text

RNA-binding proteins regulate aldosterone homeostasis in human steroidogenic cells by Fu, Rui, Wellman, Kimberly, Baldwin, Amber, Rege, Juilee, Walters, Kathryn, Hirsekorn, Antje, Riemondy, Kent, Rainey, William E, Mukherjee, Neelanjan

“…Angiotensin II (AngII) stimulates adrenocortical cells to produce aldosterone, a master regulator of blood pressure. Despite extensive characterization of the…”
Get full text

Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism by Nanba, Aya T., Nanba, Kazutaka, Byrd, James B., Shields, James J., Giordano, Thomas J., Miller, Barbara S., Rainey, William E., Auchus, Richard J., Turcu, Adina F.

“…Summary Objective Correct subtyping of primary aldosteronism (PA) is essential for good surgical outcomes. Adrenal vein sampling (AVS) and/or computed…”
Get full text

Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism by Nanba, Aya T, Wannachalee, Taweesak, Shields, James J, Byrd, James B, Rainey, William E, Auchus, Richard J, Turcu, Adina F

“…Abstract Context Many antihypertensive medications modulate the renin-angiotensin-aldosterone system, possibly skewing the diagnosis and subtyping of primary…”
Get full text

Comprehensive Analysis of Steroid Biomarkers for Guiding Primary Aldosteronism Subtyping by Turcu, Adina F., Wannachalee, Taweesak, Tsodikov, Alexander, Nanba, Aya T., Ren, Jianwei, Shields, James J., O’Day, Patrick J., Giacherio, Donald, Rainey, William E., Auchus, Richard J.

“…Adrenal vein sampling (AVS) is required to distinguish unilateral from bilateral aldosterone sources in primary aldosteronism (PA), and cortisol is used for…”
Get full text

Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas by Gong, Siyuan, Sun, Na, Meyer, Lucie S., Tetti, Martina, Koupourtidou, Christina, Krebs, Stefan, Masserdotti, Giacomo, Blum, Helmut, Rainey, William E., Reincke, Martin, Walch, Axel, Williams, Tracy Ann

“…Primary aldosteronism is frequently caused by an adrenocortical aldosterone-producing adenoma (APA) carrying a somatic mutation that drives aldosterone…”
Get full text