Search Results - "Rainer Spanagel"

Ten Points to Improve Reproducibility and Translation of Animal Research by Spanagel, Rainer

“…Findings from animal experiments are often difficult to transfer to humans. In this perspective article I discuss two questions. First, why are the results of…”
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Aberrant choice behavior in alcoholism by Spanagel, Rainer

“…Impaired neurotransmitter clearance in the amygdala is implicated in alcoholism More than 2 billion people worldwide regularly drink alcohol. Alcohol is a…”
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Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications by Bilbao, Ainhoa, Spanagel, Rainer

“…Abstract Background Medical cannabinoids differ in their pharmacology and may have different treatment effects. We aimed to conduct a pharmacology-based…”
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The alcohol deprivation effect model for studying relapse behavior: A comparison between rats and mice by Vengeliene, Valentina, Bilbao, Ainhoa, Spanagel, Rainer

“…Abstract Understanding the psychological mechanisms and underlying neurobiology of relapse behavior is essential for improving the treatment of addiction…”
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Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis by Noori, Hamid R, Cosa Linan, Alejandro, Spanagel, Rainer

“…Abstract Cue reactivity to natural and social rewards is essential for motivational behavior. However, cue reactivity to drug rewards can also elicit craving…”
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Female mice are more prone to develop an addictive-like phenotype for sugar consumption by Wei, Shoupeng, Hertle, Sarah, Spanagel, Rainer, Bilbao, Ainhoa

“…The concept of “sugar addiction” is gaining increasing attention in both the lay media and scientific literature. However, the concept of sugar addiction is…”
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Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse by Meinhardt, Marcus W, Güngör, Cansu, Skorodumov, Ivan, Mertens, Lea J, Spanagel, Rainer

“…For most psychiatric disorders, including alcohol use disorder (AUD), approved pharmacological treatments are limited in their effectiveness, and new drugs…”
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mGlu2 mechanism-based interventions to treat alcohol relapse by Vengeliene, Valentina, Spanagel, Rainer

“…Recently we identified a deficiency in metabotropic glutamate receptor 2 (mGlu2) function in the corticoaccumbal pathway, as a common pathological mechanism…”
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Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration by Pohořalá, Veronika, Enkel, Thomas, Bartsch, Dusan, Spanagel, Rainer, Bernardi, Rick E.

“…Rationale In classical conditioning, sign-tracking reflects behavior directed toward a conditioned stimulus (CS) in expectation of a reward (unconditioned…”
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Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse by Vengeliene, Valentina, Cannella, Nazzareno, Takahashi, Tatiane, Spanagel, Rainer

“…Rationale The glutamatergic system plays a key role in the maintenance of drug use and development of drug-related conditioned behaviours. In particular,…”
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Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption by Vengeliene, Valentina, Noori, Hamid R, Spanagel, Rainer

“…Melatonin is an endogenous synchronizer of biological rhythms and a modulator of physiological functions and behaviors of all mammals. Reduced levels of…”
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Acamprosate: Recent Findings and Future Research Directions by Mann, Karl, Kiefer, Falk, Spanagel, Rainer, Littleton, John

“…This article explores the mechanisms of action and the potential responder profile of acamprosate, a compound efficacious in relapse prevention of alcoholism…”
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Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc by Mameli, Manuel, Parkitna, Jan Rodriguez, Lüscher, Christian, Engblom, David, Creton, Cyril, Halbout, Briac, Spanagel, Rainer

“…The authors combine electrophysiology and behavioral assays to show that the duration of cocaine-induced synaptic plasticity in the VTA of mice is gated by…”
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Plasma calcium concentration during detoxification predicts neural cue-reactivity and craving during early abstinence in alcohol-dependent patients by Bach, Patrick, Schuster, Rilana, Koopmann, Anne, Vollstaedt-Klein, Sabine, Spanagel, Rainer, Kiefer, Falk

“…Recent studies on the pathophysiology of alcohol dependence suggest a link between peripheral calcium concentrations and alcohol craving. Here, we investigated…”
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Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence by Hirth, Natalie, Meinhardt, Marcus W., Noori, Hamid R., Salgado, Humberto, Torres-Ramirez, Oswaldo, Uhrig, Stefanie, Broccoli, Laura, Vengeliene, Valentina, Roßmanith, Martin, Perreau-Lenz, Stéphanie, Köhr, Georg, Sommer, Wolfgang H., Spanagel, Rainer, Hansson, Anita C.

“…A major hypothesis in addiction research is that alcohol induces neuroadaptations in the mesolimbic dopamine (DA) system and that these neuroadaptations…”
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Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior by Eisenhardt, Manuela, Leixner, Sarah, Luján, Rafael, Spanagel, Rainer, Bilbao, Ainhoa

“…Glutamatergic input within the mesolimbic dopamine (DA) pathway plays a critical role in the development of addictive behavior. Although this is well…”
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Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI by Cannella, Nazzareno, Cosa-Linan, Alejandro, Takahashi, Tatiane, Weber-Fahr, Wolfgang, Spanagel, Rainer

“…Cocaine addiction develops as a continuum from recreational to habitual and ultimately compulsive drug use. Cocaine addicts show reduced brain activity…”
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Comment on Flagel et al.: Sign-tracking as a predictor of addiction vulnerability by Pohořalá, Veronika, Enkel, Thomas, Bartsch, Dusan, Spanagel, Rainer, Bernardi, Rick E.

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New pharmacological treatment strategies for relapse prevention by Spanagel, Rainer, Vengeliene, Valentina

“…Here we discuss treatment strategies that are based on pharmacological interventions to reduce craving and relapse in alcohol-dependent patients. We will first…”
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Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study by Uhrig, Stefanie, Hirth, Natalie, Broccoli, Laura, von Wilmsdorff, Martina, Bauer, Manfred, Sommer, Clemens, Zink, Mathias, Steiner, Johann, Frodl, Thomas, Malchow, Berend, Falkai, Peter, Spanagel, Rainer, Hansson, Anita C, Schmitt, Andrea

“…Abstract Schizophrenia is a severe neuropsychiatric disorder with impairments in social cognition. Several brain regions have been implicated in social…”
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