Search Results - "Raina, Arun K."

Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease by Zhu, Xiongwei, Raina, Arun K., Rottkamp, Catherine A., Aliev, Gjumrakch, Perry, George, Boux, Heather, Smith, Mark A.

“…Cellular responses to increased oxidative stress appear to be a mechanism that contributes to the varied cytopathology of Alzheimer's disease (AD). In this…”
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease by Zhu, Xiongwei, Lee, Hyoung-gon, Raina, Arun K, Perry, George, Smith, Mark A

“…Given the critical role of mitogen-activated protein kinase (MAPK) pathways in regulating cellular processes that are affected in Alzheimer's disease (AD), the…”
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How important is oxidative damage? Lessons from Alzheimer’s disease by Perry, George, Raina, Arun K, Nunomura, Akihiko, Wataya, Takafumi, Sayre, Lawrence M, Smith, Mark A

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Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation by Perry, George, Roder, Hanno, Nunomura, Akihiko, Takeda, Atsushi, Friedlich, Avi L, Zhu, Xiongwei, Raina, Arun K, Holbrook, Nikki, Siedlak, Sandra L, Harris, Peggy L. R, Smith, Mark A

“…Responses to increased oxidative stress may be the common mechanism responsible for the varied cytopathology of Alzheimer disease (AD). A possible link in…”
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Alzheimer's disease: the two-hit hypothesis by Zhu, Xiongwei, Raina, Arun K, Perry, George, Smith, Mark A

“…There are many lines of evidence showing that oxidative stress and aberrant mitogenic changes have important roles in the pathogenesis of Alzheimer's disease…”
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Oxidative stress signalling in Alzheimer's disease by Zhu, Xiongwei, Raina, Arun K., Lee, Hyoung-gon, Casadesus, Gemma, Smith, Mark A., Perry, George

“…Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's disease (AD), occurring prior to cytopathology, and therefore may…”
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Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation by Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, Raina, Arun K., Vinters, Harry V., Tabaton, Massimo, Johnson, Anne B., Paula-Barbosa, Manuel, Avíla, Jesus, Jones, Paul K., Castellani, Rudy J., Smith, Mark A., Perry, George

“…Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view…”
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Redox-active iron mediates amyloid-β toxicity by Rottkamp, Catherine A, Raina, Arun K, Zhu, Xiongwei, Gaier, Elizabeth, Bush, Ashley I, Atwood, Craig S, Chevion, Mordechai, Perry, George, Smith, Mark A

“…While amyloid-β toxicity is mediated by oxidative stress and can be attenuated by antioxidants, the actual biochemical mechanism underlying neurotoxicity…”
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Apoptosis in Alzheimer disease: a mathematical improbability by Zhu, Xiongwei, Raina, Arun K, Perry, George, Smith, Mark A

“…Neuronal cell dysfunction and death are cardinal features of Alzheimer disease and a great deal of effort is being expended not only to understand factors…”
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The role of cell cycle-mediated events in Alzheimer's disease by Raina, Arun K., Monteiro, Mervyn J., Mcshea, Andrew, Smith, Mark A.

“…The mechanism(s) underlying selective neuronal death in Alzheimer's disease remain unresolved. However, recently, we and others showed that susceptible…”
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Hydroxynonenal, toxic carbonyls, and Alzheimer disease by Liu, Quan, Raina, Arun K., Smith, Mark A., Sayre, Lawrence M., Perry, George

“…Cytoskeletal disruption is one of the distinguishing characteristics of the vulnerable neurons in Alzheimer disease (AD). It has been suggested that these…”
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The cell cycle in Alzheimer disease: A unique target for neuropharmacology by Webber, Kate M., Raina, Arun K., Marlatt, Michael W., Zhu, Xiongwei, Prat, María I., Morelli, Laura, Casadesus, Gemma, Perry, George, Smith, Mark A.

“…Several hypotheses have been proposed attempting to explain the pathogenesis of Alzheimer disease including, among others, theories involving amyloid…”
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Homocysteine and Alzheimer's disease: a modifiable risk? by Dwyer, Barney E., Raina, Arun K., Perry, George, Smith, Mark A.

“…A hypothesis is proposed that reconciles the epidemiological observation of elevated homocysteine in Alzheimer's disease (AD) with clinical features of the…”
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Abortive apoptosis in Alzheimer's disease by RAINA, Arun K, HOCHMAN, Ayala, XIONGWEI ZHU, ROTTKAMP, Catherine A, NUNOMURA, Akihiko, SIEDLAK, Sandra L, BOUX, Heather, CASTELLANI, Rudolph J, PERRY, George, SMITH, Mark A

“…Multiple studies suggest that neuronal death in Alzheimer's disease (AD) is the result of an apoptotic mechanism. However, the stereotypical manifestations…”
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Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways by Zhu, Xiongwei, Raina, Arun K, Lee, Hyoung-Gon, Chao, Mark, Nunomura, Akihiko, Tabaton, Massimo, Petersen, Robert B, Perry, George, Smith, Mark A

“…Recent evidence indicates that oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the hallmark…”
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Amyloid-β junkies by Perry, George, Nunomura, Akihiko, Raina, Arun K, Smith, Mark A

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BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease by Evans, Teresa A, Raina, Arun K, Delacourte, André, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, Perry, George, Smith, Mark A

“…In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary…”
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Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease by Zhu, Xiongwei, McShea, Andrew, Harris, Peggy L.R., Raina, Arun K., Castellani, Rudy J., Funk, Jens Oliver, Shah, Sapan, Atwood, Craig, Bowen, Richard, Bowser, Robert, Morelli, Laura, Perry, George, Smith, Mark A.

“…Adult neurons are generally accepted to be in a quiescent, nonproliferative state. However, it is becoming increasingly apparent that, in Alzheimer's disease…”
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Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease by Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, Camins, Antoni, Pallàs, Mercé, Casadesus, Gemma, Lee, Hyoung-Gon, Bowser, Robert, Raina, Arun K, Perry, George, Smith, Mark A, Zhu, Xiongwei

“…The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer…”
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Increased Neuronal Glucose-6-phosphate Dehydrogenase and Sulfhydryl Levels Indicate Reductive Compensation to Oxidative Stress in Alzheimer Disease by Russell, Robert L., Siedlak, Sandra L., Raina, Arun K., Bautista, José M., Smith, Mark A., Perry, George

“…We analyzed glucose-6-phosphate dehydrogenase, the rate-controlling enzyme of the pentose phosphate pathway and free sulfhydryls, to study redox balance in…”
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