Search Results - "Railean, Violeta"

Synthesis and the in vitro evaluation of antitumor activity of novel thiobenzanilides by Álvaro Martins, Maria Joao, Railean, Violeta, martins, filomena, Machuqueiro, Miguel, Pacheco, Rita, Santos, Susana

“…Cancer is a generic term for a large group of diseases that are the second-leading cause of death worldwide, accounting for nearly 10 million deaths in 2020…”
Get full text

Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9 by Pinto, Madalena C, Quaresma, Margarida C, Silva, Iris A L, Railean, Violeta, Ramalho, Sofia S, Amaral, Margarida D

“…SLC26A9, a constitutively active Cl transporter, has gained interest over the past years as a relevant disease modifier in several respiratory disorders…”
Get full text

Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition by Quaresma, Margarida C., Pankonien, Ines, Clarke, Luka A., Sousa, Luís S., Silva, Iris A. L., Railean, Violeta, Doušová, Tereza, Fuxe, Jonas, Amaral, Margarida D.

“…Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene encoding an anion…”
Get full text

Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids by Rodenburg, Lisa W, Delpiano, Livia, Railean, Violeta, Centeio, Raquel, Pinto, Madalena C, Smits, Shannon M A, van der Windt, Isabelle S, van Hugten, Casper F J, van Beuningen, Sam F B, Rodenburg, Remco N P, van der Ent, Cornelis K, Amaral, Margarida D, Kunzelmann, Karl, Gray, Michael A, Beekman, Jeffrey M, Amatngalim, Gimano D

“…Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator…”
Get full text

Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells by Santos, Lúcia, Nascimento, Rui, Duarte, Aires, Railean, Violeta, Amaral, Margarida D, Harrison, Patrick T, Gama-Carvalho, Margarida, Farinha, Carlos M

“…The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome…”
Get full text

Personalized medicine: Function of CFTR variant p.Arg334Trp is rescued by currently available CFTR modulators by Railean, Violeta, Rodrigues, Cláudia S, Ramalho, Sofia S, Silva, Iris A L, Bartosch, Jan, Farinha, Carlos M, Pankonien, Ines, Amaral, Margarida D

“…Most of the 2,100 CFTR gene variants reported to date are still unknown in terms of their disease liability in Cystic Fibrosis (CF) and their molecular and…”
Get full text

The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion by Jo, Sungwoo, Centeio, Raquel, Park, Jinhong, Ousingsawat, Jiraporn, Jeon, Dong‐kyu, Talbi, Khaoula, Schreiber, Rainer, Ryu, Kunhi, Kahlenberg, Kristin, Somoza, Veronika, Delpiano, Livia, Gray, Michael A., Amaral, Margarida D., Railean, Violeta, Beekman, Jeffrey M., Rodenburg, Lisa W., Namkung, Wan, Kunzelmann, Karl

“…The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is assumed to contribute to airway chloride secretion and surface…”
Get full text

Systems Approaches to Unravel Molecular Function: High-content siRNA Screen Identifies TMEM16A Traffic Regulators as Potential Drug Targets for Cystic Fibrosis by Pinto, Madalena C., Botelho, Hugo M., Silva, Iris A.L., Railean, Violeta, Neumann, Beate, Pepperkok, Rainer, Schreiber, Rainer, Kunzelmann, Karl, Amaral, Margarida D.

“…[Display omitted] •Some CF patients (∼20%) are not eligible for highly effective CFTR modulator drugs.•An attractive ‘by-pass’ therapy for CF is to stimulate…”
Get full text

Personalized Medicine Based on Nasal Epithelial Cells: Comparative Studies with Rectal Biopsies and Intestinal Organoids by Silva, Iris A. L., Railean, Violeta, Duarte, Aires, Amaral, Margarida D.

“…As highly effective CFTR modulator therapies (HEMT) emerge, there is an unmet need to find effective drugs for people with CF (PwCF) with ultra-rare mutations…”
Get full text

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G by Silva, Iris A.L., Doušová, Tereza, Ramalho, Sofia, Centeio, Raquel, Clarke, Luka A., Railean, Violeta, Botelho, Hugo M., Holubová, Andrea, Valášková, Iveta, Yeh, Jiunn-Tyng, Hwang, Tzyh-Chang, Farinha, Carlos M., Kunzelmann, Karl, Amaral, Margarida D.

“…For most of the >2000 CFTR gene variants reported, neither the associated disease liability nor the underlying basic defect are known, and yet these are…”
Get full text

TMEM16A chloride channel does not drive mucus production by Simões, Filipa B, Quaresma, Margarida C, Clarke, Luka A, Silva, Iris Al, Pankonien, Ines, Railean, Violeta, Kmit, Arthur, Amaral, Margarida D

“…Airway mucus obstruction is the main cause of morbidity in cystic fibrosis, a disease caused by mutations in the CFTR Cl channel. Activation of non-CFTR Cl…”
Get full text

Produtos Naturais na Metabolização de Fármcos Quimioterápicos by Railean, Violeta

“…Atualmente, o cancro é uma das doenças mais frequentes no mundo, sendo a quimioterapia o tratamento mais comum. Muitos doentes, durante a quimioterapia…”
Get full text