Modeling of percutaneous drug transport in vitro using skin-imitating Carbosil membrane

Modeling of percutaneous drug transport in vitro using skin-imitating Carbosil membrane

A comparative study of the barrier function of human skin and polydimethylsiloxane–polycarbonate block copolymer Carbosil membrane was performed in vitro using 14 drugs spanning a wide range of structures and therapeutic classes. The drug permeability coefficients across the skin and the Carbosil me...

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Bibliographic Details
Published in:Journal of controlled release Vol. 52; no. 1; pp. 25 - 40
Main Authors: Feldstein, Mikhail M, Raigorodskii, Igor M, Iordanskii, Alexey L, Hadgraft, Jonathan
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 02-03-1998
Subjects:
Administration, Cutaneous
Biological Transport
Dimethylpolysiloxanes - administration & dosage
Drug Delivery Systems
Humans
Permeability
Polycarboxylate Cement
Polydimethylsiloxane–polycarbonate membrane
Prediction of percutaneous drug penetration
Silicones - administration & dosage
Skin - metabolism
Structure
Transdermal drug delivery
Transdermal drug delivery
Polydimethylsiloxane–polycarbonate membrane
Permeability
Structure
Prediction of percutaneous drug penetration
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Summary:A comparative study of the barrier function of human skin and polydimethylsiloxane–polycarbonate block copolymer Carbosil membrane was performed in vitro using 14 drugs spanning a wide range of structures and therapeutic classes. The drug permeability coefficients across the skin and the Carbosil membrane were examined as an explicit dependence of permeant molecular weight, melting point, solubility in aqueous solution and octanol–water partition coefficient. Owing to heterophase and heteropolar structure, Carbosil membranes and human skin epidermis share a common solubility–diffusion mechanism of drug transport. This synthetic membrane is shown to provide a mechanistically substantiated model for percutaneous drug absorption. Carbosil membranes can be used both for quantitative prediction of transdermal drug delivery rate and as a skin-imitating standard membrane in the course of in vitro drug delivery kinetics evaluation.
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ISSN:0168-3659
1873-4995
DOI:10.1016/S0168-3659(97)00208-3