Search Results - "Raife, J"

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology by Shippy, Daniel C., Wilhelm, Connor, Viharkumar, Patel A., Raife, Thomas J., Ulland, Tyler K.

“…Abstract Alzheimer’s disease (AD) is a progressive, late-onset dementia with no effective treatment available. Recent studies suggest that AD pathology is…”
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concentration of glutathione in human erythrocytes is a heritable trait by van ‘t Erve, Thomas J, Wagner, Brett A, Ryckman, Kelli K, Raife, Thomas J, Buettner, Garry R

“…Glutathione (GSH) is a ubiquitous, redox-active, small molecule that is critical to cellular and organism health. In red blood cells (RBCs), the influence of…”
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Heritability of Protein and Metabolite Biomarkers Associated with COVID-19 Severity: A Metabolomics and Proteomics Analysis by Haj, Amelia K, Hasan, Haytham, Raife, Thomas J

“…Prior studies have characterized protein and metabolite changes associated with SARS-CoV-2 infection; we hypothesized that these biomarkers may be part of…”
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Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage by Stolwijk, Jeffrey M., Stefely, Jonathan A., Veling, Mike T., van ‘t Erve, Thomas J., Wagner, Brett A., Raife, Thomas J., Buettner, Garry R.

“…The antioxidant function of the phospholipid hydroperoxide glutathione peroxidase (GPx4) is vital for the homeostasis of many cell types, from neoplastic cells…”
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Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology by Chu, Ying-Hsia, Rose, William Nicholas, Nawrot, William, Raife, Thomas J.

“…Background At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets…”
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Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site by Raife, Thomas J., Cao, Wenjing, Atkinson, Bonnie S., Bedell, Bruce, Montgomery, Robert R., Lentz, Steven R., Johnson, George F., Zheng, X. Long

“…The function of von Willebrand factor (VWF) is regulated by proteolysis, which limits its multimeric size and ability to tether platelets. The importance of…”
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Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989–2008) by Zakarija, Anaadriana, Kwaan, Hau C, Moake, Joel L, Bandarenko, Nicholas, Pandey, Dilip K, McKoy, June M, Yarnold, Paul R, Raisch, Dennis W, Winters, Jeffrey L, Raife, Thomas J, Cursio, John F, Luu, Thanh Ha, Richey, Elizabeth A, Fisher, Matthew J, Ortel, Thomas L, Tallman, Martin S, Zheng, X Long, Matsumoto, Masanori, Fujimura, Yoshihiro, Bennett, Charles L

“…Thrombotic thrombocytopenic purpura (TTP) is a fulminant disease characterized by platelet aggregates, thrombocytopenia, renal insufficiency, neurologic…”
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Ticlopidine‐associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR) by Bennett, Charles L., Jacob, Sony, Dunn, Brianne L., Georgantopoulos, Peter, Zheng, X Long, Kwaan, Hau C., McKoy, June M., Magwood, Jametta S., Qureshi, Zaina P., Bandarenko, Nicholas, Winters, Jeffrey L., Raife, Thomas J., Carey, Patricia M., Sarode, Ravindra, Kiss, Joseph E., Danielson, Constance, Ortel, Thomas L., Clark, William F., Ablin, Richard J., Rock, Gail, Matsumoto, Masanori, Fujimura, Yoshihiro

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Platelets photochemically treated with amotosalen HCl and ultraviolet A light correct prolonged bleeding times in patients with thrombocytopenia by Slichter, Sherrill J., Raife, Thomas J., Davis, Kathryn, Rheinschmidt, Margaret, Buchholz, Donald H., Corash, Laurence, Conlan, Maureen G.

“…BACKGROUND:  Photochemical treatment (PCT) with amotosalen HCl with ultraviolet A illumination inactivates pathogens and white blood cells in platelet (PLT)…”
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Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis by Raife, Thomas J, Dwyre, Denis M, Stevens, Jeff W, Erger, Rochelle A, Leo, Lorie, Wilson, Katina M, Fernández, Jose A, Wilder, Jennifer, Kim, Hyung-Suk, Griffin, John H, Maeda, Nobuyo, Lentz, Steven R

“…OBJECTIVE—We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo. METHODS AND…”
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Disseminated histoplasmosis presenting as thrombotic microangiopathy by Dwyre, Denis M., Bell, Adam M., Siechen, Kathleen, Sethi, Sanjeev, Raife, Thomas J.

“…BACKGROUND:  Thrombotic microangiopathies (TMA) are systemic vasoocclusive disorders associated with significant morbidity and mortality. Rapid and reliable…”
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The heritability of hemolysis in stored human red blood cells by Van 't Erve, Thomas J., Wagner, Brett A., Martin, Sean M., Knudson, C. Michael, Blendowski, Robyn, Keaton, Mignon, Holt, Tracy, Hess, John R., Buettner, Garry R., Ryckman, Kelli K., Darbro, Benjamin W., Murray, Jeffrey C., Raife, Thomas J.

“…BACKGROUND The transfusion of red blood cells (RBCs) with maximum therapeutic efficacy is a major goal in transfusion medicine. One of the criteria used in…”
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Heritability of glutathione and related metabolites in stored red blood cells by van 't Erve, Thomas J, Doskey, Claire M, Wagner, Brett A, Hess, John R, Darbro, Benjamin W, Ryckman, Kelli K, Murray, Jeffrey C, Raife, Thomas J, Buettner, Garry R

“…Red blood cells (RBCs) collected for transfusion deteriorate during storage. This deterioration is termed the "RBC storage lesion." There is increasing concern…”
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Retrospective cohort studies of repeat donors reveal donor‐dependent variability in the recovery of transfused platelets by Stefely, Jonathan A., Gailey, Michael, Knudson, Michael, Dumont, Larry J., Raife, Thomas J., Samia, Noelle I.

“…BACKGROUND The in vivo recovery of transfused platelets is variable and often unpredictable. Although many recipient‐dependent factors are well described,…”
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Severe autoimmune neutropenia associated with acute autoimmune hepatitis by Wehbe, Ahmad M., Johannsson, Birgir, Raife, Thomas J., Bleile, Michelle, Bell, Adam, Curtis, Brian R., Halfdanarson, Thorvardur R.

“…A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the…”
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Thienopyridine‐linked thrombotic microangiopathy: association with endothelial cell apoptosis and activation of MAP kinase signalling cascades by Mauro, Michael, Zlatopolskiy, Andrey, Raife, Thomas J., Laurence, Jeffrey

“…Summary The thienopyridine platelet antagonist ticlopidine is associated with development of thrombotic thrombocytopenic purpura (TTP) but the pathophysiology…”
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Age-dependent Prevalence of Vascular Disease-associated Polymorphisms among 2689 Volunteer Blood Donors by Hessner, Martin J, Dinauer, David M, Kwiatkowski, Robert, Neri, Bruce, Raife, Thomas J

“…The development of vascular disease involves the interaction of genetic and environmental factors. Because vascular disease is a major contributor to mortality…”
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The heritability of metabolite concentrations in stored human red blood cells by van 't Erve, Thomas J., Wagner, Brett A., Martin, Sean M., Knudson, C. Michael, Blendowski, Robyn, Keaton, Mignon, Holt, Tracy, Hess, John R., Buettner, Garry R., Ryckman, Kelli K., Darbro, Benjamin W., Murray, Jeffrey C., Raife, Thomas J.

“…Background The degeneration of red blood cells (RBCs) during storage is a major issue in transfusion medicine. Family studies in the 1960s established the…”
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Multi-omics Evidence for Inheritance of Energy Pathways in Red Blood Cells by Weisenhorn, Erin M.M., van ′t Erve, Thomas J., Riley, Nicholas M., Hess, John R., Raife, Thomas J., Coon, Joshua J.

“…Each year over 90 million units of blood are transfused worldwide. Our dependence on this blood supply mandates optimized blood management and storage. During…”
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The changing paradigm of thrombotic thrombocytopenic purpura by Raife, Thomas J

“…New discoveries have changed a 20-year-old concept about the mechanism of microvascular thrombosis in thrombotic thrombocytopenic purpura (TTP). The classic…”
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