Search Results - "Rai, Rekha"

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions by Rai, Rekha, Chen, Yong, Lei, Ming, Chang, Sandy

“…Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ),…”
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Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex by Hu, Chunyi, Rai, Rekha, Huang, Chenhui, Broton, Cayla, Long, Juanjuan, Xu, Ying, Xue, Jing, Lei, Ming, Chang, Sandy, Chen, Yong

“…Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by…”
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NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres by Rai, Rekha, Hu, Chunyi, Broton, Cayla, Chen, Yong, Lei, Ming, Chang, Sandy

“…Telomeres employ TRF2 to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), thereby repressing ATM-dependent DNA damage…”
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Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly by Cicconi, Alessandro, Rai, Rekha, Xiong, Xuexue, Broton, Cayla, Al-Hiyasat, Amer, Hu, Chunyi, Dong, Siying, Sun, Wenqi, Garbarino, Jennifer, Bindra, Ranjit S., Schildkraut, Carl, Chen, Yong, Chang, Sandy

“…Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of…”
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TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA by Zou, Lee, Flynn, Rachel Litman, Centore, Richard C, O'Sullivan, Roderick J, Rai, Rekha, Tse, Alice, Songyang, Zhou, Chang, Sandy, Karlseder, Jan

“…Maintenance of telomeres requires both DNA replication and telomere 'capping' by shelterin. These two processes use two single-stranded DNA (ssDNA)-binding…”
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The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres by Rai, Rekha, Zheng, Hong, He, Hua, Luo, Ying, Multani, Asha, Carpenter, Phillip B, Chang, Sandy

“…Repair of DNA double‐stranded breaks (DSBs) is crucial for the maintenance of genome stability. DSBs are repaired by either error prone non‐homologous…”
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Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1 by Rai, Rekha, Biju, Kevin, Sun, Wenqi, Sodeinde, Tori, Al-Hiyasat, Amer, Morgan, Jaida, Ye, Xianwen, Li, Xueqing, Chen, Yong, Chang, Sandy

“…Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome stability. Dysfunctional telomeres are recognized as DSBs and are…”
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Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer by Chen, Cong, Gu, Peili, Wu, Jian, Chen, Xianyun, Niu, Shuangshuang, Sun, Hong, Wu, Lijie, Li, Na, Peng, Junhui, Shi, Shaohua, Fan, Cuiying, Huang, Min, Wong, Catherine C. L., Gong, Qingguo, Kumar-Sinha, Chandan, Zhang, Rongguang, Pusztai, Lajos, Rai, Rekha, Chang, Sandy, Lei, Ming

“…Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates telomerase-mediated telomere extension…”
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The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function by Rai, Rekha, Gu, Peili, Broton, Cayla, Kumar-Sinha, Chandan, Chen, Yong, Chang, Sandy

“…Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated…”
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Author Correction: Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1 by Rai, Rekha, Biju, Kevin, Sun, Wenqi, Sodeinde, Tori, Al-Hiyasat, Amer, Morgan, Jaida, Ye, Xianwen, Li, Xueqing, Chen, Yong, Chang, Sandy

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A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms by Chang, Sandy, Lei, Ming, Chen, Yong, Rai, Rekha, Zhou, Zi-Ren, Kanoh, Junko, Ribeyre, Cyril, Yang, Yuting, Zheng, Hong, Damay, Pascal, Wang, Feng, Tsujii, Hisayo, Hiraoka, Yasushi, Shore, David, Hu, Hong-Yu

“…Telomere protein RAP1 is found in organisms from yeast to mammals, but has different functions. Now the crystal structures of the RAP1 C-terminus (RCT) with…”
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BRIT1/MCPH1 Is a DNA Damage Responsive Protein That Regulates the Brca1-Chk1 Pathway, Implicating Checkpoint Dysfunction in Microcephaly by Lin, Shiaw-Yih, Rekha Rai, Li, Kaiyi, Zhi-Xiang Xu, Elledge, Stephen J.

“…BRIT1 [BRCT-repeat inhibitor of hTERT expression], a repressor of human telomerase function, is implicated in cellular immortalization. Here, we find that…”
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Fatal Sepsis and Septic Shock Secondary to Aeromonas hydrophila Pneumonia: Report of a Case and Review of the Literature by Chaithra, Kanishan, Shetty, Veena A, Rai, Rekha R, Sharma, Raghav R, Shetty, Avinash K

“…Aeromonas hydrophila belongs to the family Aeromonadaceae and is ubiquitous in distribution. It can be widely isolated from environmental sources such as…”
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Differential regulation of centrosome integrity by DNA damage response proteins by Rai, Rekha, Phadnis, Ashwini, Haralkar, Sharda, Badwe, Rajender A., Dai, Hui, Li, Kaiyi, Lin, Shiaw-Yih

“…MDC1 and BRIT1 have been shown to function as key regulators in response to DNA damage. However, their roles in centrosomal regulation haven't been elucidated…”
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BRIT1/MCPH1: A Guardian of Genome and an Enemy of Tumors by Chaplet, Michael, Rai, Rekha, Jackson-Bernitsas, Deborah, Li, Kaiyi, Lin, Shiaw-Yih

“…The DNA of every cell is constantly exposed to insult mediated by endogenous and environmental factors that induced damage in its structure. To react to these…”
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Distribution of microorganisms in neonatal sepsis and antimicrobial susceptibility patterns in a tertiary care hospital by Nayak, Sweetha, Rai, Rekha, Kumar, VimalK, Sanjeev, H, Pai, Asha, Ganesh, HR

“…Introduction: Neonatal sepsis is one of the leading causes of neonatal deaths in developing countries. The organisms responsible for early onset and late onset…”
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TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection by Liang, Fengshan, Rai, Rekha, Sodeinde, Tori, Chang, Sandy

“…Abstract Inappropriate homology-directed repair (HDR) of telomeres results in catastrophic telomere loss and aberrant chromosome fusions, leading to genome…”
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Telomeres cooperate with the nuclear envelope to maintain genome stability by Rai, Rekha, Sodeinde, Tori, Boston, Ava, Chang, Sandy

“…Mammalian telomeres have evolved safeguards to prevent their recognition as DNA double‐stranded breaks by suppressing the activation of various DNA sensing and…”
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Probing the Telomere Damage Response by Rai, Rekha, Chang, Sandy

“…Telomere dysfunctions, rendered through replicative attrition of telomeric DNA or due to the removal of shelterin components, are recognized as DNA…”
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Haemophilus Influenzae, an Underdiagnosed Cause of Respiratory Tract Infections by Rekha Rai, Vimal Kumar K., Ganesh Ramanath, Krishnaprasad Madle S., Sanjeev Hosdurg, Asha Pai K.B.

“…Background: Haemophilus influenzae is an obligate human parasite that is transmitted from person to person by the respiratory route. This organism causes…”
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