Search Results - "Rahmeh, Amal A"

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy by Liang, Bo, Li, Zongli, Jenni, Simon, Rahmeh, Amal A., Morin, Benjamin M., Grant, Timothy, Grigorieff, Nikolaus, Harrison, Stephen C., Whelan, Sean P.J.

“…The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization…”
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Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer by Kennedy, Edward M., Denslow, Agnieszka, Hewett, Jacqueline, Kong, Lingxin, De Almeida, Ana, Bryant, Jeffrey D., Lee, Jennifer S., Jacques, Judy, Feau, Sonia, Hayes, Melissa, McMichael, Elizabeth L., Wambua, Daniel, Farkaly, Terry, Rahmeh, Amal A, Herschelman, Lauren, Douglas, Danielle, Spinale, Jacob, Adhikari, Sanmit, Deterling, Jessica, Scott, Matt, Haines, Brian B., Finer, Mitchell H., Ashburn, Ted T, Quéva, Christophe, Lerner, Lorena

“…The therapeutic effectiveness of oncolytic viruses (OVs) delivered intravenously is limited by the development of neutralizing antibody responses against the…”
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Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase by Morin, Benjamin, Rahmeh, Amal A, Whelan, Sean PJ

“…The minimal RNA synthesis machinery of non‐segmented negative‐strand RNA viruses comprises a genomic RNA encased within a nucleocapsid protein (N‐RNA), and…”
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Protein expression redirects vesicular stomatitis virus RNA synthesis to cytoplasmic inclusions by Heinrich, Bianca S, Cureton, David K, Rahmeh, Amal A, Whelan, Sean P J

“…Positive-strand and double-strand RNA viruses typically compartmentalize their replication machinery in infected cells. This is thought to shield viral RNA…”
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Molecular architecture of the vesicular stomatitis virus RNA polymerase by Rahmeh, Amal A., Schenk, Andreas D., Danek, Eric I., Kranzusch, Philip J., Liang, Bo, Walz, Thomas, Whelan, Sean P. J., Lamb, Robert A.

“…Nonsegmented negative-strand (NNS) RNA viruses initiate infection by delivering into the host cell a highly specialized RNA synthesis machine comprising the…”
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Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus by Rahmeh, Amal A, Morin, Benjamin, Schenk, Andreas D, Liang, Bo, Heinrich, Bianca S, Brusic, Vesna, Walz, Thomas, Whelan, Sean P. J

“…The RNA-dependent RNA polymerase (RdRP) of nonsegmented negative-sense RNA viruses consists of a large catalytic protein (L) and a phosphoprotein cofactor (P)…”
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Ribose 2′-O Methylation of the Vesicular Stomatitis Virus mRNA Cap Precedes and Facilitates Subsequent Guanine-N-7 Methylation by the Large Polymerase Protein by RAHMEH, Amal A, JIANRONG LI, KRANZUSCH, Philip J, WHELAN, Sean P. J

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Assembly of a functional Machupo virus polymerase complex by Kranzusch, Philip J., Schenk, Andreas D., Rahmeh, Amal A., Radoshitzky, Sheli R., Bavari, Sina, Walz, Thomas, Whelan, Sean P. J., Lamb, Robert A.

“…Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for…”
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A freeze frame view of vesicular stomatitis virus transcription defines a minimal length of RNA for 5' processing by Tekes, Gergely, Rahmeh, Amal A, Whelan, Sean P J

“…The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated…”
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The polymerase of negative-stranded RNA viruses by Morin, Benjamin, Kranzusch, Philip J, Rahmeh, Amal A, Whelan, Sean PJ

“…•Comparative structure and function analysis of RNA synthesis machinery of negative-sense RNA viruses.•Unique biology of mRNA capping: cap snatching versus cap…”
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Structural Properties of the C Terminus of Vesicular Stomatitis Virus N Protein Dictate N-RNA Complex Assembly, Encapsidation, and RNA Synthesis by HEINRICH, Bianca S, MORIN, Benjamin, RAHMEH, Amal A, WHELAN, Sean P. J

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PDIP46 (DNA polymerase δ interacting protein 46) is an activating factor for human DNA polymerase δ by Wang, Xiaoxiao, Zhang, Sufang, Zheng, Rong, Yue, Fu, Lin, Szu Hua Sharon, Rahmeh, Amal A, Lee, Ernest Y C, Zhang, Zhongtao, Lee, Marietta Y W T

“…PDIP46 (SKAR, POLDIP3) was discovered through its interaction with the p50 subunit of human DNA polymerase δ (Pol δ). Its functions in DNA replication are…”
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Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch To Regulate Its Interaction with PCNA by Rahmeh, Amal A, Zhou, Yajing, Xie, Bin, Li, Hao, Lee, Ernest Y. C, Lee, Marietta Y. W. T

“…DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair. Pol δ is a complex of four subunits p125, p68, p50, and p12. The…”
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Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats by Mikati, Mohamad A., Kurdi, Rana M., Rahmeh, Amal A., Farhat, Firas, Rialy, Suha Abu, Lteif, Lina, Francis, Elie, Geha, George, Maraashli, Wael

“…Purpose: To investigate if energy precursor supplementation is neuroprotective in two neuroexcitotoxicity models; the kainate and the kainate followed by…”
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Mechanism of RNA synthesis initiation by the vesicular stomatitis virus polymerase: Mechanism of RNA synthesis initiation by VSV polymerase by Morin, Benjamin, Rahmeh, Amal A, Whelan, Sean PJ

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Protein Expression Redirects Vesicular Stomatitis Virus RNA Synthesis to Cytoplasmic Inclusions: e1000958 by Heinrich, Bianca S, Cureton, David K, Rahmeh, Amal A, Whelan, Sean PJ

“…Positive-strand and double-strand RNA viruses typically compartmentalize their replication machinery in infected cells. This is thought to shield viral RNA…”
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Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain by Mikati, Mohamad A, Werner, Suzanne, Gatt, Arkadi, Liu, Zhao, Rahmeh, Amal A, Rachid, Rima A, Stafstrom, Carl E, Holmes, Gregory L

“…To investigate if AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activation contributes to acute manifestations and long term…”
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