Search Results - "Rahman, Khondaker Miraz"

Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria by Gauba, Anusha, Rahman, Khondaker Miraz

“…Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing one of the most urgent global healthcare and economic threats. Due…”
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Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-Negative (ESKAPEE) Bacteria by Reza, Akif, Sutton, J Mark, Rahman, Khondaker Miraz

“…Antibiotic resistance represents a significant threat to the modern healthcare provision. The ESKAPEE pathogens ( and ), in particular, have proven to be…”
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Antibiotic resistance breakers: current approaches and future directions by Laws, Mark, Shaaban, Ali, Rahman, Khondaker Miraz

“…Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The investigation of novel approaches for tackling the antimicrobial…”
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Isolation and Characterization of One New Natural Compound with Other Potential Bioactive Secondary Metabolites from Glycosmis cyanocarpa (Blume) Spreng. (Family: Rutaceae) by Islam, Md Ariful, Ashrafi, Sania, Rahman, Khondaker Miraz, Ahmed, Shamim, Molla Jamal, A H M Shofiul Islam, Ahsan, Monira

“…(Blume) Spreng is a plant in the Rutaceae family and a species in the Glycosmis genus that has received little attention. Therefore, this research aimed to…”
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Nonclinical Evaluation of Single-Mutant E. coli Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses by Ruiz-Lara, Grace, Costa-Silva, Tales A, Muso-Cachumba, Jorge Javier, Cevallos Espinel, Johanna, Fontes, Marina Gabriel, Garcia-Maya, Mitla, Rahman, Khondaker Miraz, Rangel-Yagui, Carlota de Oliveira, Monteiro, Gisele

“…Acute lymphoblastic leukaemia is currently treated with bacterial L-asparaginase; however, its side effects raise the need for the development of improved and…”
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Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease by Sekhar, Gayathri Nair, Fleckney, Alice L, Boyanova, Sevda Tomova, Rupawala, Huzefa, Lo, Rachel, Wang, Hao, Farag, Doaa B, Rahman, Khondaker Miraz, Broadstock, Martin, Reeves, Suzanne, Thomas, Sarah Ann

“…Research into amisulpride use in Alzheimer's disease (AD) implicates blood-brain barrier (BBB) dysfunction in antipsychotic sensitivity. Research into BBB…”
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Isolation and In Silico Prediction of Potential Drug-like Compounds with a New Dimeric Prenylated Quinolone Alkaloid from Zanthoxylum rhetsa (Roxb.) Root Extracts Targeted against SARS-CoV-2 (Mpro) by Zohora, Fatema Tuz, Azam, A T M Zafrul, Ahmed, Sinthyia, Rahman, Khondaker Miraz, Halim, Mohammad A, Anwar, Md Rafi, Sohrab, Md Hossain, Tabassum, Fatema, Hasan, Choudhury Mahmood, Ahsan, Monira

“…A new dimeric prenylated quinolone alkaloid, named 2,11-didemethoxy-vepridimerine A, was isolated from the root bark of , together with twelve known compounds…”
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Schiff bases of sulphonamides as a new class of antifungal agent against multidrug‐resistant Candida auris by Hamad, Asad, Chen, Yiyuan, Khan, Mohsin A., Jamshidi, Shirin, Saeed, Naima, Clifford, Melanie, Hind, Charlotte, Sutton, J. Mark, Rahman, Khondaker Miraz

“…Invasive Candida infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There…”
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Fusaproliferin, a Fungal Mycotoxin, Shows Cytotoxicity against Pancreatic Cancer Cell Lines by Hoque, Nazia, Hasan, Choudhury Mahmood, Rana, Md Sohel, Varsha, Amrit, Sohrab, Md Hossain, Rahman, Khondaker Miraz

“…As a part of our ongoing research on endophytic fungi, we have isolated a sesterterpene mycotoxin, fusaproliferin (FUS), from a strain, which is associated…”
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Role of bacterial efflux pumps in biofilm formation by Alav, Ilyas, Sutton, J Mark, Rahman, Khondaker Miraz

“…Efflux pumps are widely implicated in antibiotic resistance because they can extrude the majority of clinically relevant antibiotics from within cells to the…”
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Antibody-Drug Conjugates-A Tutorial Review by Baah, Stephanie, Laws, Mark, Rahman, Khondaker Miraz

“…Antibody-drug conjugates (ADCs) are a family of targeted therapeutic agents for the treatment of cancer. ADC development is a rapidly expanding field of…”
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Covalent DNA Binding Is Essential for Gram-Negative Antibacterial Activity of Broad Spectrum Pyrrolobenzodiazepines by Picconi, Pietro, Hind, Charlotte K, Sutton, J Mark, Rahman, Khondaker Miraz

“…It is urgent to find new antibiotic classes against multidrug-resistant bacteria as the rate of discovery of new classes of antibiotics has been very slow in…”
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Exploring bias in platelet P2Y1 signalling: Host defence versus haemostasis by Pan, Dingxin, Ladds, Graham, Rahman, Khondaker Miraz, Pitchford, Simon C.

“…Platelets are necessary for maintaining haemostasis. Separately, platelets are important for the propagation of inflammation during the host immune response…”
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Mapping the Dynamic Functions and Structural Features of AcrB Efflux Pump Transporter Using Accelerated Molecular Dynamics Simulations by Jamshidi, Shirin, Sutton, J. Mark, Rahman, Khondaker Miraz

“…Multidrug efflux pumps confer resistance to their bacterial hosts by pumping out a diverse range of compounds, including most antibiotics. Being more familiar…”
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Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling by Arkless, Kate L., Pan, Dingxin, Shankar‐Hari, Manu, Amison, Richard T., Page, Clive P., Rahman, Khondaker Miraz, Pitchford, Simon C.

“…Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides. Non‐canonical signalling via the P2Y1…”
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Probing sulphamethazine and sulphamethoxazole based Schiff bases as urease inhibitors; synthesis, characterization, molecular docking and ADME evaluation by Hamad, Asad, Abbas Khan, Mohsin, Ahmad, Irshad, Imran, Aqeel, Khalil, Ruqaiya, Al-Adhami, Taha, Miraz Rahman, Khondaker, Quratulain, Zahra, Nudrat, Shafiq, Zahid

“…[Display omitted] •A new series of Sulphamethazine and Sulphamethoxazole (3a-q) was synthesized.•Probed the compounds (3a-q) as urease Inhibitors.•SAR revealed…”
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Cytotoxic Naphthoquinone and Azaanthraquinone Derivatives from an Endophytic Fusarium solani by Chowdhury, Nargis Sultana, Sohrab, Md. Hossain, Rana, Md. Sohel, Hasan, Choudhury Mahmood, Jamshidi, Shirin, Rahman, Khondaker Miraz

“…Bioactivity-guided fractionation of the ethyl acetate extract obtained from the culture of the endophytic fungus Fusarium solani resulted in the isolation of…”
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Author Correction: Mapping the Dynamic Functions and Structural Features of AcrB Efflux Pump Transporter Using Accelerated Molecular Dynamics Simulations by Jamshidi, Shirin, Sutton, J. Mark, Rahman, Khondaker Miraz

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation by Imran, Aqeel, Tariq Shehzad, Muhammad, al Adhami, Taha, Miraz Rahman, Khondaker, Hussain, Dilawar, Alharthy, Rima D., Shafiq, Zahid, Iqbal, Jamshed

“…[Display omitted] •A series of coumarin-based thiosemicarbazone derivatives was synthesized.•The synthesized compounds were investigated for their enzyme…”
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Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study by Imran, Aqeel, Shehzad, Muhammad Tariq, Shah, Syed Jawad Ali, al Adhami, Taha, Laws, Mark, Rahman, Khondaker Miraz, Alharthy, Rima D., Khan, Imtiaz Ali, Shafiq, Zahid, Iqbal, Jamshed

“…The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an…”
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