Search Results - "Rahman, F. Abdel"
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Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy
Published in Nature medicine (01-02-2020)“…Frameshift mutations in the DMD gene, encoding dystrophin, cause Duchenne muscular dystrophy (DMD), leading to terminal muscle and heart failure in patients…”
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2
Regression of fibrosis by cilostazol in a rat model of thioacetamide-induced liver fibrosis: Up regulation of hepatic cAMP, and modulation of inflammatory, oxidative stress and apoptotic biomarkers
Published in PloS one (08-05-2019)“…In liver fibrosis, conversion of fibroblasts to profibrogenic myofibroblasts significantly drives the development of the disease. A crucial role of cyclic…”
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3
Phytoconstituents of Sansevieria suffruticosa N.E.Br. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally Induced Liver Fibrosis Rat Model
Published in Chemistry & biodiversity (01-04-2022)“…Sansevieria species possess antioxidant and hepatoprotective activities. However, the therapeutic potential of Sansevieria suffruticosa N.E.Br. in liver…”
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4
Characterization and control of Rhizoctonia solani affecting lucky bamboo (Dracaena sanderiana hort. ex. Mast.) using some bioagents
Published in Scientific reports (24-04-2023)“…In a survey conducted during the period of March–May 2019 in nurseries, warehouses, and shops at three governorates (Alexandria, El-Behera, and Giza…”
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Green Synthesis of Highly Fluorescent Carbon Dots from Bovine Serum Albumin for Linezolid Drug Delivery as Potential Wound Healing Biomaterial: Bio-Synergistic Approach, Antibacterial Activity, and In Vitro and Ex Vivo Evaluation
Published in Pharmaceutics (10-01-2023)“…A simple and green approach was developed to produce novel highly fluorescent bovine serum albumin carbon dots (BCDs) via facile one-step hydrothermal…”
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Protective Effect of Beta -Carotene against Myeloperoxidase- Mediated Oxidative Stress and Inflammation in Rat Ischemic Brain Injury
Published in Antioxidants (27-11-2022)“…Oxidative stress and inflammatory reaction play critical roles in ischemia/reperfusion (I/R) injury in the brain. β-carotene (βCAR) is a naturally occurring…”
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Anti-inflammatory and antioxidant activities of naringin isolated from Carissa carandas L.: In vitro and in vivo evidence
Published in Phytomedicine (Stuttgart) (15-03-2018)“…Carissa carandas L. is known in folk medicine for its anti-inflammatory and hepatoprotective activities. Meanwhile it is an evergreen shrub that constitutes a…”
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Neuroprotective effect of vildagliptin against cerebral ischemia in rats
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-10-2018)“…Stroke is the leading cause of death worldwide. Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of anti-diabetic drugs for treatment of type-2 diabetes…”
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9
Estrogenic activity of Sage (Salvia officinalis L.) aerial parts and its isolated ferulic acid in immature ovariectomized female rats
Published in Journal of ethnopharmacology (10-01-2022)“…Common sage (Salvia officinalis L., Lamiaceae), a medicinal plant of Mediterranean origin, has been traditionally applied in cases of excessive sweating, and…”
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Is there a correlation between -174(G/C) polymorphism of IL-6 gene and the incidence of acute myocardial infarction?
Published in Journal of Genetic Engineering and Biotechnology (20-09-2021)“…Background Cardiovascular disease (CVD) remains the major cause of death worldwide. Most CVD can be prevented by addressing risk factors. Acute myocardial…”
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C(-260)T Polymorphism in CD14 Receptor Gene of Egyptians with Acute Myocardial Infarction
Published in Current pharmaceutical biotechnology (01-01-2018)“…Despite the significance of the traditional risk factors, recently published studies have suggested that inflammatory processes and variations in the genetics…”
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12
Oleuropein Relieves Pancreatic Ischemia Reperfusion Injury in Rats by Suppressing Inflammation and Oxidative Stress through HMGB1/NF-κB Pathway
Published in International journal of molecular sciences (22-09-2024)“…Oleuropein (OLP) is a naturally occurring phenolic compound in olive plant with antioxidant and anti-inflammatory potential and can possibly be used in…”
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1,8 Cineole and Ellagic acid inhibit hepatocarcinogenesis via upregulation of MiR-122 and suppression of TGF-β1, FSCN1, Vimentin, VEGF, and MMP-9
Published in PloS one (01-01-2022)“…Hepatocellular carcinoma (HCC) is one of the most burdened tumors worldwide, with a complex and multifactorial pathogenesis. Current treatment approaches…”
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14
Polymorphisms in Gap Junction Proteins and their Role in Predisposition of Acute Myocardial Infarction in Egyptians
Published in Current pharmaceutical biotechnology (10-11-2017)“…Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have…”
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The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study
Published in Journal of advanced research (01-01-2020)“…[Display omitted] •The manuscript describes the link of vitamin D deficiency to acute coronary syndrome.•It tackles megalin and cubilin genetic variants in ACS…”
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In Vivo Investigation of the Ameliorating Effect of Tempol against MIA-Induced Knee Osteoarthritis in Rats: Involvement of TGF-β1/SMAD3/NOX4 Cue
Published in Molecules (Basel, Switzerland) (19-11-2021)“…Osteoarthritis (OA) is a complex disease characterized by structural, functional, and metabolic deteriorations of the whole joint and periarticular tissues. In…”
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The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats
Published in PloS one (01-12-2021)“…The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic fibrosis as a characteristic response to persistent liver…”
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Regulation of PKB/Akt-pathway in the chemopreventive effect of lactoferrin against diethylnitrosamine-induced hepatocarcinogenesis in rats
Published in Pharmacological reports (01-10-2019)“…Abnormal activation of protein kinase B (PKB) is associated with many cancers. This makes inhibition of PKB signaling pathway a promising strategy for cancer…”
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Vulgarin, a Sesquiterpene Lactone from Artemisia judaica , Improves the Antidiabetic Effectiveness of Glibenclamide in Streptozotocin-Induced Diabetic Rats via Modulation of PEPCK and G6Pase Genes Expression
Published in International journal of molecular sciences (13-12-2022)“…The current investigation assessed the effect of the eudesmanolid, Vulgarin (VGN), obtained from ( ), on the antidiabetic potential of glibenclamide (GLB)…”
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Miconazole Mitigates Acetic Acid-Induced Experimental Colitis in Rats: Insight into Inflammation, Oxidative Stress and Keap1/Nrf-2 Signaling Crosstalk
Published in Biology (Basel, Switzerland) (13-02-2022)“…Ulcerative colitis (UC) is the most common type of inflammatory bowel disease, characterized by oxidative stress and elevated pro-inflammatory cytokines…”
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