Search Results - "Rahl, Peter B"

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes by Whyte, Warren A., Orlando, David A., Hnisz, Denes, Abraham, Brian J., Lin, Charles Y., Kagey, Michael H., Rahl, Peter B., Lee, Tong Ihn, Young, Richard A.

“…Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and recruit Mediator to activate much of the gene expression program of pluripotent…”
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Transcriptional Amplification in Tumor Cells with Elevated c-Myc by Lin, Charles Y., Lovén, Jakob, Rahl, Peter B., Paranal, Ronald M., Burge, Christopher B., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

“…Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. The…”
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Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma by Chapuy, Bjoern, McKeown, Michael R., Lin, Charles Y., Monti, Stefano, Roemer, Margaretha G.M., Qi, Jun, Rahl, Peter B., Sun, Heather H., Yeda, Kelly T., Doench, John G., Reichert, Elaine, Kung, Andrew L., Rodig, Scott J., Young, Richard A., Shipp, Margaret A., Bradner, James E.

“…Diffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and…”
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Revisiting Global Gene Expression Analysis by Lovén, Jakob, Orlando, David A., Sigova, Alla A., Lin, Charles Y., Rahl, Peter B., Burge, Christopher B., Levens, David L., Lee, Tong Ihn, Young, Richard A.

“…Gene expression analysis is a widely used and powerful method for investigating the transcriptional behavior of biological systems, for classifying cell states…”
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Mediator and cohesin connect gene expression and chromatin architecture by Taatjes, Dylan J, van Berkum, Nynke L, Young, Richard A, Kagey, Michael H, Bilodeau, Steve, Zhan, Ye, Ebmeier, Christopher C, Levine, Stuart S, Newman, Jamie J, Rahl, Peter B, Dekker, Job, Goossens, Jesse, Orlando, David A

“…Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene…”
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SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state by Bilodeau, Steve, Kagey, Michael H, Frampton, Garrett M, Rahl, Peter B, Young, Richard A

“…Transcription factors that play key roles in regulating embryonic stem (ES) cell state have been identified, but the chromatin regulators that help maintain ES…”
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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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Divergent Transcription from Active Promoters by Seila, Amy C, Calabrese, J. Mauro, Levine, Stuart S, Yeo, Gene W, Rahl, Peter B, Flynn, Ryan A, Young, Richard A, Sharp, Phillip A

“…Transcription initiation by RNA polymerase II (RNAPII) is thought to occur unidirectionally from most genes. Here, we present evidence of widespread divergent…”
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Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells by Giraud, Matthieu, Yoshida, Hideyuki, Abramson, Jakub, Rahl, Peter B, Young, Richard A, Mathis, Diane, Benoist, Christophe

“…Aire is a transcriptional regulator that induces expression of peripheral tissue antigens (PTA) in thymic medullary epithelial cells (MECs), driving…”
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Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes by Cheng, Bo, Li, Tiandao, Rahl, Peter B., Adamson, Todd E., Loudas, Nicholas B., Guo, Jiannan, Varzavand, Katayoun, Cooper, Jeffrey J., Hu, Xiaopeng, Gnatt, Averell, Young, Richard A., Price, David H.

“…Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by…”
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BET bromodomain proteins regulate enhancer function during adipogenesis by Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Young, Richard A., Plutzky, Jorge, Bradner, James E.

“…Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of…”
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Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts by Gurtan, Allan M, Ravi, Arvind, Rahl, Peter B, Bosson, Andrew D, JnBaptiste, Courtney K, Bhutkar, Arjun, Whittaker, Charles A, Young, Richard A, Sharp, Phillip A

“…MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult…”
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Elp1p, the Yeast Homolog of the FD Disease Syndrome Protein, Negatively Regulates Exocytosis Independently of Transcriptional Elongation by Rahl, Peter B., Chen, Catherine Z., Collins, Ruth N.

“…The activation of Rab GTPases is a critical focal point of membrane trafficking events in eukaryotic cells; however, the cellular mechanisms that spatially and…”
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Targeting transcription regulation in cancer with a covalent CDK7 inhibitor by Kwiatkowski, Nicholas, Zhang, Tinghu, Rahl, Peter B., Abraham, Brian J., Reddy, Jessica, Ficarro, Scott B., Dastur, Anahita, Amzallag, Arnaud, Ramaswamy, Sridhar, Tesar, Bethany, Jenkins, Catherine E., Hannett, Nancy M., McMillin, Douglas, Sanda, Takaomi, Sim, Taebo, Kim, Nam Doo, Look, Thomas, Mitsiades, Constantine S., Weng, Andrew P., Brown, Jennifer R., Benes, Cyril H., Marto, Jarrod A., Young, Richard A., Gray, Nathanael S.

“…Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia…”
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c-Myc Regulates Transcriptional Pause Release by Rahl, Peter B., Lin, Charles Y., Seila, Amy C., Flynn, Ryan A., McCuine, Scott, Burge, Christopher B., Sharp, Phillip A., Young, Richard A.

“…Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized…”
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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc by Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

“…MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this…”
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Bioinformatic and Comparative Localization of Rab Proteins Reveals Functional Insights into the Uncharacterized GTPases Ypt10p and Ypt11p by Buvelot Frei, Stéphanie, Rahl, Peter B., Nussbaum, Maria, Briggs, Benjamin J., Calero, Monica, Janeczko, Stephanie, Regan, Andrew D., Chen, Catherine Z., Barral, Yves, Whittaker, Gary R., Collins, Ruth N.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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DHODH modulates transcriptional elongation in the neural crest and melanoma by White, Richard Mark, Cech, Jennifer, Ratanasirintrawoot, Sutheera, Lin, Charles Y., Rahl, Peter B., Burke, Christopher J., Langdon, Erin, Tomlinson, Matthew L., Mosher, Jack, Kaufman, Charles, Chen, Frank, Long, Hannah K., Kramer, Martin, Datta, Sumon, Neuberg, Donna, Granter, Scott, Young, Richard A., Morrison, Sean, Wheeler, Grant N., Zon, Leonard I.

“…Oncogenes BRAF(V600E) and SETDB1 in melanoma Transgenic zebrafish carrying the human oncogene BRAF(V600E) , the most common mutation in melanoma patients,…”
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Genome-wide localization of small molecules by Anders, Lars, Guenther, Matthew G, Qi, Jun, Fan, Zi Peng, Marineau, Jason J, Rahl, Peter B, Lovén, Jakob, Sigova, Alla A, Smith, William B, Lee, Tong Ihn, Bradner, James E, Young, Richard A

“…A new method called Chem-seq reveals the genomic binding sites of drugs that target DNA and chromatin. A vast number of small-molecule ligands, including…”
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MYC and transcription elongation by Rahl, Peter B, Young, Richard A

“…Most transcription factors specify the subset of genes that will be actively transcribed in the cell by stimulating transcription initiation at these genes,…”
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