Search Results - "Rahikainen, Rolle"

Approaching infinite affinity through engineering of peptide–protein interaction by Keeble, Anthony H., Turkki, Paula, Stokes, Samuel, Anuar, Irsyad N. A. Khairil, Rahikainen, Rolle, Hytönen, Vesa P., Howarth, Mark

“…Much of life’s complexity depends upon contacts between proteins with precise affinity and specificity. The successful application of engineered proteins often…”
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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses by Tan, Tiong Kit, Rijal, Pramila, Rahikainen, Rolle, Keeble, Anthony H., Schimanski, Lisa, Hussain, Saira, Harvey, Ruth, Hayes, Jack W. P., Edwards, Jane C., McLean, Rebecca K., Martini, Veronica, Pedrera, Miriam, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Zagrajek, Adrian K., Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Tully, Matthew, Moffat, Katy, Chiu, Chris, Waters, Ryan, Gray, Ashley, Azhar, Mehreen, Mioulet, Valerie, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Hammond, John A., Tchilian, Elma, Charleston, Bryan, Bailey, Dalan, Tuthill, Tobias J., Graham, Simon P., Duyvesteyn, Helen M. E., Malinauskas, Tomas, Huo, Jiandong, Tree, Julia A., Buttigieg, Karen R., Owens, Raymond J., Carroll, Miles W., Daniels, Rodney S., McCauley, John W., Stuart, David I., Huang, Kuan-Ying A., Howarth, Mark, Townsend, Alain R.

“…There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle…”
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation by Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark

“…Matching of symmetry at interfaces is a fundamental obstacle in molecular assembly. Virus‐like particles (VLPs) are important vaccine platforms against…”
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Mechanotransduction in talin through the interaction of the R8 domain with DLC1 by Haining, Alexander William M, Rahikainen, Rolle, Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair, von Essen, Magdalena, Hytönen, Vesa P, Del Río Hernández, Armando

“…The mechanical unfolding of proteins is a cellular mechanism for force transduction with potentially broad implications in cell fate. Despite this, the…”
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A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 by Townsend, Alain, Rijal, Pramila, Xiao, Julie, Tan, Tiong Kit, Huang, Kuan-Ying A., Schimanski, Lisa, Huo, Jiandong, Gupta, Nimesh, Rahikainen, Rolle, Matthews, Philippa C., Crook, Derrick, Hoosdally, Sarah, Dunachie, Susanna, Barnes, Eleanor, Street, Teresa, Conlon, Christopher P., Frater, John, Arancibia-Cárcamo, Carolina V., Rudkin, Justine, Stoesser, Nicole, Karpe, Fredrik, Neville, Matthew, Ploeg, Rutger, Oliveira, Marta, Roberts, David J., Lamikanra, Abigail A., Tsang, Hoi Pat, Bown, Abbie, Vipond, Richard, Mentzer, Alexander J., Knight, Julian C., Kwok, Andrew J., Screaton, Gavin R., Mongkolsapaya, Juthathip, Dejnirattisai, Wanwisa, Supasa, Piyada, Klenerman, Paul, Dold, Christina, Baillie, J. Kenneth, Moore, Shona C., Openshaw, Peter J. M., Semple, Malcolm G., Turtle, Lance C. W., Ainsworth, Mark, Allcock, Alice, Beer, Sally, Bibi, Sagida, Skelly, Donal, Stafford, Lizzy, Jeffrey, Katie, O’Donnell, Denise, Clutterbuck, Elizabeth, Espinosa, Alexis, Mendoza, Maria, Georgiou, Dominique, Lockett, Teresa, Martinez, Jose, Perez, Elena, Gallardo Sanchez, Veronica, Scozzafava, Giuseppe, Sobrinodiaz, Alberto, Thraves, Hannah, Joly, Etienne

“…Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, and for seeking evidence for a level of…”
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SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly by Vester, Susan K., Rahikainen, Rolle, Khairil Anuar, Irsyad N. A., Hills, Rory A., Tan, Tiong Kit, Howarth, Mark

“…Proteins can be empowered via SpyTag for anchoring and nanoassembly, through covalent bonding to SpyCatcher partners. Here we generate a switchable version of…”
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Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force by Mykuliak, Vasyl V, Rahikainen, Rolle, Ball, Neil J, Bussi, Giovanni, Goult, Benjamin T, Hytönen, Vesa P

“…Vinculin binds to specific sites of mechanically unfolded talin rod domains to reinforce the coupling of the cell's exterior to its force generation machinery…”
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Mechanical stability of talin rod controls cell migration and substrate sensing by Rahikainen, Rolle, von Essen, Magdaléna, Schaefer, Markus, Qi, Lei, Azizi, Latifeh, Kelly, Conor, Ihalainen, Teemu O., Wehrle-Haller, Bernhard, Bastmeyer, Martin, Huang, Cai, Hytönen, Vesa P.

“…Cells adhere to the surrounding tissue and probe its mechanical properties by forming cell-matrix adhesions. Talin is a critical adhesion protein and…”
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The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering by Kukkurainen, Sampo, Azizi, Latifeh, Zhang, Pingfeng, Jacquier, Marie-Claude, Baikoghli, Mo, von Essen, Magdaléna, Tuukkanen, Anne, Laitaoja, Mikko, Liu, Xiaonan, Rahikainen, Rolle, Orłowski, Adam, Jänis, Janne, Määttä, Juha A E, Varjosalo, Markku, Vattulainen, Ilpo, Róg, Tomasz, Svergun, Dmitri, Cheng, R Holland, Wu, Jinhua, Hytönen, Vesa P, Wehrle-Haller, Bernhard

“…Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic…”
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Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study by von Essen, Magdaléna, Rahikainen, Rolle, Oksala, Niku, Raitoharju, Emma, Seppälä, Ilkka, Mennander, Ari, Sioris, Thanos, Kholova, Ivana, Klopp, Norman, Illig, Thomas, Karhunen, Pekka, Kähönen, Mika, Lehtimäki, Terho, Hytönen, Vesa P

“…Abstract Background and aims Focal adhesions (FA) play an important role in the tissue remodeling and in the maintenance of tissue integrity and homeostasis…”
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Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing by Pinon, Perrine, Pärssinen, Jenita, Vazquez, Patricia, Bachmann, Michael, Rahikainen, Rolle, Jacquier, Marie-Claude, Azizi, Latifeh, Määttä, Juha A, Bastmeyer, Martin, Hytönen, Vesa P, Wehrle-Haller, Bernhard

“…Integrin-dependent cell adhesion and spreading are critical for morphogenesis, tissue regeneration, and immune defense but also tumor growth. However, the…”
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A novel chimeric avidin with increased thermal stability using DNA shuffling by Taskinen, Barbara, Airenne, Tomi T, Jänis, Janne, Rahikainen, Rolle, Johnson, Mark S, Kulomaa, Markku S, Hytönen, Vesa P

“…Avidins are a family of proteins widely employed in biotechnology. We have previously shown that functional chimeric mutant proteins can be created from avidin…”
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Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation by Rahikainen, Rolle, Rijal, Pramila, Tan, Tiong Kit, Wu, Hung‐Jen, Andersson, Anne‐Marie C., Barrett, Jordan R., Bowden, Thomas A., Draper, Simon J., Townsend, Alain R., Howarth, Mark

“…Matching of symmetry at interfaces is a fundamental obstacle in molecular assembly. Virus‐like particles (VLPs) are important vaccine platforms against…”
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Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling by Rahikainen, Rolle, Öhman, Tiina, Turkki, Paula, Varjosalo, Markku, Hytönen, Vesa P

“…Talin protein is one of the key components in integrin-mediated adhesion complexes. Talins transmit mechanical forces between β-integrin and actin, and…”
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ConFERMing the role of talin in integrin activation and mechanosignaling by Bachmann, Michael, Su, Baihao, Rahikainen, Rolle, Hytönen, Vesa P, Wu, Jinhua, Wehrle-Haller, Bernhard

“…Talin (herein referring to the talin-1 form), is a cytoskeletal adapter protein that binds integrin receptors and F-actin, and is a key factor in the formation…”
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Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion by Rahikainen, Rolle, Vester, Susan K., Turkki, Paula, Janosko, Chasity P., Deiters, Alexander, Hytönen, Vesa P., Howarth, Mark

“…Light is well-established for control of bond breakage but not for control of specific bond formation in complex environments. We previously engineered the…”
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Enhancement of adhesion and promotion of osteogenic differentiation of human adipose stem cells by poled electroactive poly(vinylidene fluoride) by Pärssinen, Jenita, Hammarén, Henrik, Rahikainen, Rolle, Sencadas, Vitor, Ribeiro, Clarisse, Vanhatupa, Sari, Miettinen, Susanna, Lanceros-Méndez, Senentxu, Hytönen, Vesa P.

“…Poly(vinylidene fluoride) (PVDF) is a biocompatible material with excellent electroactive properties. Nonelectroactive α‐PVDF and electroactive β‐PVDF were…”
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Mixture of PLA–PEG and biotinylated albumin enables immobilization of avidins on electrospun fibers by Kumar, Manish, Rahikainen, Rolle, Unruh, Daniel, Hytönen, Vesa P., Delbrück, Cesare, Sindelar, Ralf, Renz, Franz

“…The application of nanotechnology in biomedical field has enormous potential in basic and applied research. Micro or nanofibers produced by electrospinning…”
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Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption by Hyunh, Ngoc Bao, Palma, Cristina Santos Dias, Rahikainen, Rolle, Mishra, Ayush, Azizi, Latifeh, Verne, Enrica, Ferraris, Sara, Hytönen, Vesa Pekka, Sanches Ribeiro, Andre, Massera, Jonathan

“…The traditional silicate bioactive glasses exhibit poor thermal processability, which inhibits fiber drawing or sintering into scaffolds. The composition of…”
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His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display by Koho, Tiia, Ihalainen, Teemu O., Stark, Marie, Uusi-Kerttula, Hanni, Wieneke, Ralph, Rahikainen, Rolle, Blazevic, Vesna, Marjomäki, Varpu, Tampé, Robert, Kulomaa, Markku S., Hytönen, Vesa P.

“…[Display omitted] In addition to vaccines, noninfectious virus-like particles (VLPs) that mimic the viral capsid show an attractive possibility of presenting…”
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