Search Results - "Rahemtulla, Amin"
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Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
Published in Blood (30-01-2014)“…The bromodomain and extraterminal (BET) protein BRD2-4 inhibitors hold therapeutic promise in preclinical models of hematologic malignancies. However,…”
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Clinical drug resistance linked to interconvertible phenotypic and functional states of tumor-propagating cells in multiple myeloma
Published in Blood (10-01-2013)“…The phenotype and function of cells enriched in tumor-propagating activity and their relationship to the phenotypic architecture in multiple myeloma (MM) are…”
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Impact of route and adequacy of nutritional intake on outcomes of allogeneic haematopoietic cell transplantation for haematologic malignancies
Published in Clinical nutrition (Edinburgh, Scotland) (01-04-2019)“…Allogeneic haematopoietic cell transplantation (HCT) is often associated with poor oral intake due to painful mucositis and gastrointestinal sequalae that…”
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Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease
Published in The Journal of clinical investigation (01-06-2015)“…Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in…”
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Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells
Published in PloS one (17-09-2013)“…Inhibition of the proteasome is a widely used strategy for treating multiple myeloma that takes advantage of the heavy secretory load that multiple myeloma…”
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Regulation of multiple myeloma survival and progression by CD1d
Published in Blood (12-03-2009)“…Down-regulation of conventional human leukocyte antigen (HLA) class I and II molecules from the surface of tumor cells is an important mechanism for tumor…”
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Optimizing patient selection for myeloablative allogeneic hematopoietic cell transplantation in chronic myeloid leukemia in chronic phase
Published in Blood (20-05-2010)“…Outstanding results have been obtained in the treatment of chronic myeloid leukemia (CML) with first-line imatinib therapy. However, approximately 35% of…”
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Significance of macrophage inflammatory protein-1 alpha (MIP-1α) in multiple myeloma
Published in Leukemia & lymphoma (01-12-2005)“…Macrophage inflammatory protein-1 alpha (MIP-1α) is a member of the CC chemokine family and is primarily associated with cell adhesion and migration. It is…”
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The role of markers of bone remodeling in multiple myeloma
Published in Blood reviews (01-05-2005)“…Osteolytic bone disease is a frequent complication of multiple myeloma, resulting in skeletal complications that are a significant cause of morbidity and…”
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Plasmacytoma relapses in the absence of systemic progression post-high-dose therapy for multiple myeloma
Published in European journal of haematology (01-11-2005)“…: Autologous (ASCT) and allogeneic stem cell transplantations (alloBMT) are well‐established therapies for multiple myeloma. However, patients continue to…”
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Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment
Published in Nature immunology (01-12-2001)“…The mechanism of T cell lineage commitment remains controversial; to examine it we deleted the CD4-silencer element in the germ line of a mouse using a…”
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Factors Influencing the Outcome of a Second Autologous Stem Cell Transplant (ASCT) in Relapsed Multiple Myeloma: A Study from the British Society of Blood and Marrow Transplantation Registry
Published in Biology of blood and marrow transplantation (01-11-2011)“…Autologous stem cell transplant as primary (first ASCT) therapy in multiple myeloma (MM) is standard practice. The role of a second ASCT as management of…”
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14
Pulse oximetry error in a patient with a Santa Ana haemoglobinopathy
Published in BMJ case reports (06-09-2016)“…A young man with a rare unstable haemoglobinopathy presented with a high fever, worsening shortness of breath and abdominal pain. At triage his pulse oximetry…”
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Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation
Published in Blood (24-05-2012)“…Invariant natural killer T (iNKT) cells are powerful immunomodulatory cells that in mice regulate a variety of immune responses, including acute GVHD (aGVHD)…”
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Hodgkin's lymphoma (relapsed or refractory): autologous stem cell therapy
Published in Clinical evidence (London : 2006) (26-10-2015)“…People with Hodgkin's lymphoma usually present with a lump in the neck or upper chest, but a quarter of people also have fever, sweating, weight loss, fatigue,…”
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Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors
Published in Cancer cell (13-10-2014)“…Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell…”
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Rational treatment of chemotherapy-induced peripheral neuropathy with capsaicin 8% patch: from pain relief towards disease modification
Published in Journal of pain research (01-07-2019)“…Chemotherapy-induced peripheral neuropathy (CIPN) with associated chronic pain is a common and disabling condition. Current treatments for neuropathic pain in…”
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Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8
Published in European journal of immunology (01-06-1993)“…Using the technique of homologous recombination in embryonic stem cells, a mouse strain without functional CD4 and CD8 genes has been generated. Surprisingly,…”
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Percutaneous vertebroplasty to treat painful myelomatous vertebral deposits--long-term efficacy outcomes
Published in Annals of hematology (01-01-2011)“…Developed for benign conditions including osteoporotic fractures and haemangiomas, vertebroplasty has since been employed in neoplastic lesions, including…”
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