Frequency and risk factors of narrow angles in patients with pseudoexfoliation: a case–control study

Frequency and risk factors of narrow angles in patients with pseudoexfoliation: a case–control study

Purpose To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients. Methods A prospective case–control study was conducted during the period from March 2017 to December 2020. Adult patients (above 40 years) presenting with PXF were consecutively enrolled (study...

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Bibliographic Details
Published in:International ophthalmology Vol. 42; no. 4; pp. 1085 - 1091
Main Authors: Al Owaifeer, Adi Mohammed, AlObaida, Ibrahim, Alzuhairy, Sultan, Raheman, Syed J., Aljasim, Leyla, Edward, Deepak P.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-04-2022
Springer Nature B.V
Subjects:
Adult
Age groups
Aged
Case-Control Studies
Exfoliation Syndrome - epidemiology
Gender
Glaucoma
Humans
Intraocular Pressure
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Patients
Risk analysis
Risk Factors
Glaucoma
Narrow angle
Pseudoexfoliation
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Summary:Purpose To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients. Methods A prospective case–control study was conducted during the period from March 2017 to December 2020. Adult patients (above 40 years) presenting with PXF were consecutively enrolled (study group). Cases were matched with individuals above 40 years presenting to a comprehensive ophthalmology clinic without evidence of PXF (control group). Results We enrolled 196 PXF patients and 98 controls. The occurrence of narrow angles was 25% in the PXF group and 5.1% in the control group ( P  = 0.0001). Compared to controls, PXF patients were older (72.6 ± 9.6 vs. 64.4 ± 8.5, P  < 0.0001) and had a lower mean ACD (2.79 ± 0.4 vs. 3.05 ± 0.4, P  < 0.0001). There was no difference in AL measurements between both groups (23.3 ± 1.4 vs. 23.7 ± 1.0, P  = 0.0714). After stratification by age group and gender, the risk of narrow angles was higher in PXF patients above 70 years (OR, 4.15; 95% CI, 0.91–23.87; P , 0.044). There was no gender difference in the risk of developing narrow angles. Conclusion Narrow angles are more frequently encountered in PXF patients compared to controls. Advanced age (> 70 years) is significantly associated with an increased likelihood of developing narrow angles.
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ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-021-02094-4