Search Results - "Ragonnaud, Emeline"

Gut microbiota as the key controllers of "healthy" aging of elderly people by Ragonnaud, Emeline, Biragyn, Arya

“…Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human healthy aging, and thus, longevity. They do so by targeting at…”
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Therapeutic B-cell depletion reverses progression of Alzheimer’s disease by Kim, Ki, Wang, Xin, Ragonnaud, Emeline, Bodogai, Monica, Illouz, Tomer, DeLuca, Marisa, McDevitt, Ross A., Gusev, Fedor, Okun, Eitan, Rogaev, Evgeny, Biragyn, Arya

“…The function of B cells in Alzheimer’s disease (AD) is not fully understood. While immunoglobulins that target amyloid beta (Aβ) may interfere with plaque…”
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Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition by Pomatto-Watson, Laura C. D., Bodogai, Monica, Bosompra, Oye, Kato, Jonathan, Wong, Sarah, Carpenter, Melissa, Duregon, Eleonora, Chowdhury, Dolly, Krishna, Priya, Ng, Sandy, Ragonnaud, Emeline, Salgado, Roberto, Gonzalez Ericsson, Paula, Diaz-Ruiz, Alberto, Bernier, Michel, Price, Nathan L., Biragyn, Arya, Longo, Valter D., de Cabo, Rafael

“…Cancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer…”
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Cancer co-opts differentiation of B-cell precursors into macrophage-like cells by Chen, Chen, Park, Bongsoo, Ragonnaud, Emeline, Bodogai, Monica, Wang, Xin, Zong, Le, Lee, Jung-Min, Beerman, Isabel, Biragyn, Arya

“…We have recently reported that some cancers induce accumulation of bone marrow (BM) B-cell precursors in the spleen to convert them into metastasis-promoting,…”
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Cancer Associated Endogenous Retroviruses: Ideal Immune Targets for Adenovirus-Based Immunotherapy by Vergara Bermejo, Amaia, Ragonnaud, Emeline, Daradoumis, Joana, Holst, Peter

“…Cancer is a major challenge in our societies, according to the World Health Organization (WHO) about 1/6 deaths were cancer related in 2018 and it is…”
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Tumor-Derived Thymic Stromal Lymphopoietin Expands Bone Marrow B-cell Precursors in Circulation to Support Metastasis by Ragonnaud, Emeline, Moritoh, Kanako, Bodogai, Monica, Gusev, Fedor, Garaud, Soizic, Chen, Chen, Wang, Xin, Baljinnyam, Tuvshintugs, Becker, Kevin G, Maul, Robert W, Willard-Gallo, Karen, Rogaev, Evgeny, Biragyn, Arya

“…Immature B cells in the bone marrow emigrate into the spleen during adult lymphopoiesis. Here, we report that emigration is shifted to earlier B-cell stages in…”
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Human Ad19a/64 HERV-W Vaccines Uncover Immunosuppression Domain-Dependent T-Cell Response Differences in Inbred Mice by Skandorff, Isabella, Ragonnaud, Emeline, Gille, Jasmin, Andersson, Anne-Marie, Schrödel, Silke, Duvnjak, Lara, Turner, Louise, Thirion, Christian, Wagner, Ralf, Holst, Peter Johannes

“…Expression of human endogenous retrovirus type W (HERV-W) has been linked to cancer, making HERV-W antigens potential targets for therapeutic cancer vaccines…”
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The Insertion of an Evolutionary Lost Four-Amino-Acid Cytoplasmic Tail Peptide into a Syncytin-1 Vaccine Increases T- and B-Cell Responses in Mice by Skandorff, Isabella, Gille, Jasmin, Ragonnaud, Emeline, Andersson, Anne-Marie, Schrödel, Silke, Thirion, Christian, Wagner, Ralf, Holst, Peter Johannes

“…Human endogenous retrovirus type W (HERV-W) is expressed in various cancers. We previously developed an adenovirus-vectored cancer vaccine targeting HERV-W by…”
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An Endogenous Retrovirus Vaccine Encoding an Envelope with a Mutated Immunosuppressive Domain in Combination with Anti-PD1 Treatment Eradicates Established Tumours in Mice by Daradoumis, Joana, Ragonnaud, Emeline, Skandorff, Isabella, Nielsen, Karen Nørgaard, Bermejo, Amaia Vergara, Andersson, Anne-Marie, Schroedel, Silke, Thirion, Christian, Neukirch, Lasse, Holst, Peter Johannes

“…Endogenous retroviruses (ERVs) account for 8% of our genome, and, although they are usually silent in healthy tissues, they become reactivated and expressed in…”
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Targeting of non-dominant antigens as a vaccine strategy to broaden T-cell responses during chronic viral infection by Holst, Peter J, Jensen, Benjamin A H, Ragonnaud, Emeline, Thomsen, Allan R, Christensen, Jan P

“…In this study, we compared adenoviral vaccine vectors with the capacity to induce equally potent immune responses against non-dominant and immunodominant…”
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1147-F Human endogenous retrovirus-K proteins form VLPs with dense envelope incorporation – explaining HERV-K immunogenicity in patients and yielding a tool for breaking tolerance to HERV envelope proteins by Bermejo, Amaia V, Skandorff, Isabella, Neukirch, Lasse, Gille, Jasmin, Bagger, Frederik O, Nielsen, Karen N, Daradoumis, Joana, Ince, Charlie R, Duvnjak, Lara, Müller, Mikkel D, Schrödel, Silke, Turner, Louise, Grunddal, Kaare, Straten, Per thor, Rohrberg, Kristoffer Staahl, Thirion, Christian, Wagner, Ralf, Andersson, Anne-Marie, Ragonnaud, Emeline, Holst, Peter

“…BackgroundHuman endogenous retroviruses and, in particular the betaretrovirus HERV-K, are upregulated at the protein level in a wide range of cancers…”
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The rationale of vectored gene-fusion vaccines against cancer: evolving strategies and latest evidence by Ragonnaud, Emeline, Holst, Peter

“…The development of vaccines that target tumor antigens in cancer has proven difficult. A major reason for this is that T cells specific for tumor self-antigens…”
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Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication by Xu, Huanbin, Andersson, Anne-Marie, Ragonnaud, Emeline, Boilesen, Ditte, Tolver, Anders, Jensen, Benjamin Anderschou Holbech, Blanchard, James L., Nicosia, Alfredo, Folgori, Antonella, Colloca, Stefano, Cortese, Riccardo, Thomsen, Allan Randrup, Christensen, Jan Pravsgaard, Veazey, Ronald S., Holst, Peter Johannes

“…Conventional HIV T cell vaccine strategies have not been successful in containing acute peak viremia, nor in providing long-term control. We immunized rhesus…”
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A surprising pathogenic role of B cells in mice with Alzheimer’s disease by Biragyn, Arya, Kim, Ki, Wang, Xin, Ragonnaud, Emeline, Bodogai, Monica, McDevitt, Ross A, Okun, Eitan

“…Abstract The role of adaptive immune cells in Alzheimer’s disease (AD), a progressive neurodegenerative disease that associates with impaired clearance of…”
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CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis by Wang, Xin, Campbell, Britney, Bodogai, Monica, McDevitt, Ross A., Patrikeev, Anton, Gusev, Fedor, Ragonnaud, Emeline, Kumaraswami, Konda, Shirenova, Sophie, Vardy, Karin, Alameh, Mohamed-Gabriel, Weissman, Drew, Ishikawa-Ankerhold, Hellen, Okun, Eitan, Rogaev, Evgeny, Biragyn, Arya

“…•We provide evidence that CD8+ T cells infiltrate the brain to exacerbate AD.•The CD8+ T cells are induced by B cells.•Strategies that inactivate B cells or…”
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Abstract 4499: Cancer targets early B-cell precursors to generate metastasis-promoting Bregs by promoting their premature emigration from the bone marrow and expansion in the circulation by Ragonnaud, Emeline, Moritoh, Kanako, Bodogai, Monica, Garaud, Soizic, Chen, Chen, Wang, Xin, Willard-Gallo, Karen, Biragyn, Arya

“…Abstract We previously reported that breast cancer (BC) generates metastasis-promoting regulatory B cells (CD25+ tumor-evoked Bregs). Because phenotypically…”
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Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques by Ragonnaud, Emeline, Schroedel, Silke, Mariya, Silmi, Iskandriati, Diah, Pamungkas, Joko, Fougeroux, Cyrielle, Daradoumis, Joana, Thomsen, Allan R., Neukirch, Lasse, Ruzsics, Zsolt, Salomon, Michael, Thirion, Christian, Holst, Peter J.

“…The human adenovirus type 19a/64 (hAd19a) is a rare serotype in the human population that transduces human dendritic cells (DCs) and human muscle cells more…”
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CD8+ T cells induced by adenovirus-vectored vaccine are capable of preventing establishment of latent murine γ-herpesvirus 68 infection by Boilesen, Ditte R., Ragonnaud, Emeline, Laursen, Henriette, Andersson, Anne-Marie C., Tolver, Anders, Spiess, Katja, Holst, Peter J.

“…CD8+ T cells are known to control infections, but their role in preventing latent infection from establishing has not been thoroughly investigated. We…”
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An adenoviral cancer vaccine co-encoding a tumor associated antigen together with secreted 4-1BBL leads to delayed tumor progression by Ragonnaud, Emeline, Andersson, Anne-Marie C, Pedersen, Anders Elm, Laursen, Henriette, Holst, Peter J

“…Abstract Previous studies have shown promising results when using an agonistic anti-4-1BB antibody treatment against established tumors. While this is…”
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Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations by Andersson, Anne-Marie C, Ragonnaud, Emeline, Seaton, Kelly E, Sawant, Sheetal, Folgori, Antonella, Colloca, Stefano, Labranche, Celia, Montefiori, David C, Tomaras, Georgia D, Holst, Peter J

“…Highlights • Adenoviral heterologous prime-double boost continuously increase antibody responses. • CON-S CT truncation increases antigen presentation with a…”
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