Search Results - "Ragland, Debra A"

Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond by Matthew, Ashley N, Leidner, Florian, Lockbaum, Gordon J, Henes, Mina, Zephyr, Jacqueto, Hou, Shurong, Rao, Desaboini Nageswara, Timm, Jennifer, Rusere, Linah N, Ragland, Debra A, Paulsen, Janet L, Prachanronarong, Kristina, Soumana, Djade I, Nalivaika, Ellen A, Kurt Yilmaz, Nese, Ali, Akbar, Schiffer, Celia A

“…Drug resistance is prevalent across many diseases, rendering therapies ineffective with severe financial and health consequences. Rather than accepting…”
Get full text

Characterizing Protein–Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV‑1 Protease by Whitfield, Troy W, Ragland, Debra A, Zeldovich, Konstantin B, Schiffer, Celia A

“…Over the past several decades, atomistic simulations of biomolecules, whether carried out using molecular dynamics or Monte Carlo techniques, have provided…”
Get full text

Interdependence of Inhibitor Recognition in HIV‑1 Protease by Paulsen, Janet L, Leidner, Florian, Ragland, Debra A, Kurt Yilmaz, Nese, Schiffer, Celia A

“…Molecular recognition is a highly interdependent process. Subsite couplings within the active site of proteases are most often revealed through conditional…”
Get full text

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV‑1 Protease by Ragland, Debra A, Nalivaika, Ellen A, Nalam, Madhavi N. L, Prachanronarong, Kristina L, Cao, Hong, Bandaranayake, Rajintha M, Cai, Yufeng, Kurt-Yilmaz, Nese, Schiffer, Celia A

“…HIV-1 protease inhibitors are part of the highly active antiretroviral therapy effectively used in the treatment of HIV infection and AIDS. Darunavir (DRV) is…”
Get full text

Elucidating the Interdependence of Drug Resistance from Combinations of Mutations by Ragland, Debra A, Whitfield, Troy W, Lee, Sook-Kyung, Swanstrom, Ronald, Zeldovich, Konstantin B, Kurt-Yilmaz, Nese, Schiffer, Celia A

“…HIV-1 protease is responsible for the cleavage of 12 nonhomologous sites within the Gag and Gag-Pro-Pol polyproteins in the viral genome. Under the selective…”
Get full text

Implementing the hidden curriculum for biomedical graduate research trainees: leveraging qualitative data and student affairs personnel to develop soft skills by Ragland, Debra A., Lowry, Augustus J., Nardone-White, Dasean T., Frierson, Johnna M.

“…Biomedical graduate research trainees are increasingly pursuing careers beyond academia in response to limited academic positions relative to the trainee…”
Get full text