Search Results - "Raghubir, Ram"

Endoplasmic Reticulum Stress Plays Critical Role in Brain Damage After Cerebral Ischemia/Reperfusion in Rats by Nakka, Venkata Prasuja, Gusain, Anchal, Raghubir, Ram

“…The endoplasmic reticulum(ER) stress plays a vital role in mediating ischemic neuronal cell death. However, very little is known about the role of ER stress in…”
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Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia by Singh, Neetu, Sharma, Gaurav, Mishra, Vikas, Raghubir, Ram

“…A divergence in the supply and consumption of oxygen in brain tissue initiates complex cycle of biochemical and molecular events resulting in neuronal death…”
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Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury by Verma, Rajkumar, Mishra, Vikas, Sasmal, Dinakar, Raghubir, Ram

“…Recently glutamate transporters have emerged as a potential therapeutic target in a wide range of acute and chronic neurological disorders, owing to their…”
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Molecular Mechanisms of Apoptosis in Cerebral Ischemia: Multiple Neuroprotective Opportunities by Nakka, Venkata Prasuja, Gusain, Anchal, Mehta, Suresh L., Raghubir, Ram

“…Cerebral ischemia/reperfusion (I/R) injury triggers multiple and distinct but overlapping cell signaling pathways, which may lead to cell survival or cell…”
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Molecular targets in cerebral ischemia for developing novel therapeutics by Mehta, Suresh L, Manhas, Namratta, Raghubir, Ram

“…Abstract Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular mechanisms that impairs the neurologic functions through breakdown…”
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Antioxidant status during cutaneous wound healing in immunocompromised rats by Gupta, Asheesh, Singh, Ram L, Raghubir, Ram

“…The present investigation was undertaken to investigate the endogenous status of free radical scavengers during cutaneous wound healing in immunocompromised…”
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Synthesis and biological evaluation of 2-thiopyrimidine derivatives by Sondhi, Sham M., Goyal, Rajendra N., Lahoti, Anand M., Singh, Nirupma, Shukla, Rakesh, Raghubir, Ram

“…Various 2-thiopyrimidine derivatives have been synthesized by condensation of functionalized amines with β-isothiocyanatoketones. Some compounds showed…”
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Multifaceted Web Resources for Stroke by Hanif, Kashif, MSc, PhD, Raghubir, Ram, MVSc, PhD

“…The Internet is an increasingly important tool for stroke survivors, their family members, and health care providers and researchers. An immense amount of…”
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Emerging Role of Astrocytes in Cerebral Ischemia/Reperfusion Injury by Raghubir, Dr. Ram

“…Astrocytes are not merely supportive to neurons but also perform crucial brain functions such as maintenance of ionic homeostasis, neovascularization,…”
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Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives by Sondhi Sham, Bhattacharjee Gurudas, Jameel Rafid, Shukla Rakesh, Raghubir Ram, Lozach Olivier, Meijer Laurent

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Neuroprotective potential of the NF-κB inhibitor peptide IKK-NBD in cerebral ischemia-reperfusion injury by Desai, Abhishek, Singh, Nilendra, Raghubir, Ram

“…▶ The NF-κB inhibitor peptide IKK-NBD shows neuroprotective potential. ▶ The IKK-NBD peptide reduced neurological deficits after cerebral stroke in rats. ▶ It…”
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Neuroprotective effect of flurbiprofen in focal cerebral ischemia: The possible role of ASIC1a by Mishra, Vikas, Verma, Rajkumar, Raghubir, Ram

“…The intracellular calcium overload resulting from glutamate excitotoxicity is considered major determinant for neuronal loss during cerebral ischemia…”
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Stem cell therapy: a hope for dying hearts by Sharma, Rishi, Raghubir, Ram

“…The restoration of functional myocardium following heart failure still remains a formidable challenge among researchers. Irreversible damage caused by…”
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The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury by Mishra, Vikas, Verma, Rajkumar, Singh, Neetu, Raghubir, Ram

“…Abstract Owing to the complex and multifactorial pathology of cerebral stroke, multiple drug therapy had long been advocated by STAIR committee for stroke…”
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Neuroprotection by rosiglitazone in transient focal cerebral ischemia might not be mediated by glutamate transporter-1 by Verma, Rajkumar, Mishra, Vikas, Gupta, Konica, Sasmal, Dinakar, Raghubir, Ram

“…Glutamate transport represents a key mechanism for maintaining low level of glutamate in the extracellular milieu to restrict the excitotoxic action of…”
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Endoplasmic reticulum stress in brain damage by Raghubir, Ram, Nakka, Venkata Prasuja, Mehta, Suresh L

“…The efficient functioning of the ER is indispensable for most of the cellular activities and survival. Disturbances in the physiological functions of the ER…”
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Flavone-Based Novel Antidiabetic and Antidyslipidemic Agents by Verma, Alok K, Singh, Himanshu, Satyanarayana, Mavurapu, Srivastava, Swayam P, Tiwari, Priti, Singh, Amar B, Dwivedi, Anil K, Singh, Shio K, Srivastava, Mukesh, Nath, Chandishwar, Raghubir, Ram, Srivastava, Arvind K, Pratap, Ram

“…The hybrid congeners 62–90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in…”
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Chalcone-based aryloxypropanolamine as a potential antidiabetic and antidyslipidaemic agent by Shukla, Poonam, Satyanarayana, Mavurapu, Verma, Prem C., Tiwari, Jaya, Dwivedi, Atma P., Srivastava, Rohit, Rehuja, Neha, Srivastava, Swayam P., Gautam, Sudeep, Tamrakar, Akhilesh K., Dwivedi, Anil K., Kushwaha, Hari N., Gautam, Nagsen, Singh, Shio K., Srivastava, Mukesh, Nath, Chandishwar, Raghubir, Ram, Srivastava, Arvind K., Pratap, Ram

“…The hybrid congener 3 derived from hydroxychalcone and pharmacophore oxypropanolamine for adrenergic receptor, along with its enantiomers 9a and 9b were…”
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Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents by Sashidhara, Koneni V., Rosaiah, Jammikuntla N., Tyagi, Ethika, Shukla, Rakesh, Raghubir, Ram, Rajendran, Siron M.

“…In the course of our studies on the isolation of bioactive compounds from the roots of Moringa oleifera, a traditional herb in southeast Asia, rare…”
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Antagonism of haloperidol-induced swim impairment in l-dopa and caffeine treated mice: A pre-clinical model to study Parkinson's disease by Luthra, Pratibha Mehta, Barodia, Sandeep Kumar, Raghubir, Ram

“…Parkinson's disease (PD) exhibits symptoms of motor dysfunction such as tremor, akinesia and rigidity. Agents that selectively disrupt or destroy…”
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