Search Results - "Raghavan, Somasundaram"

SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity by Raghavan, Somasundaram, Kenchappa, Divya Borsandra, Leo, M Dennis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin converting enzyme 2 (ACE2) receptor present on the cell surface to enter…”
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Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells by Raghavan, Somasundaram, Leo, M Dennis

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is one of the most serious global health crises in…”
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Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function by Chattopadhyay, Rima, Raghavan, Somasundaram, Rao, Gadiparthi N

“…Resolvins are a novel class of lipid mediators that play an important role in the resolution of inflammation, although the underlying mechanisms are not very…”
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Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3–mediated degradation of the ABCA1 transporter by Raghavan, Somasundaram, Singh, Nikhlesh K., Mani, Arul M., Rao, Gadiparthi N.

“…Although signaling of thrombin via its receptor protease-activated receptor 1 (Par1) is known to occur in atherothrombosis, its link to the actual pathogenesis…”
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Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function by Raghavan, Somasundaram, Brishti, Masuma Akter, Collier, Daniel Mohr, Leo, M Dennis

“…Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When…”
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Proinflammatory effects of malondialdehyde in lymphocytes by Raghavan, Somasundaram, Subramaniyam, Ganesan, Shanmugam, Narkunaraja

“…MDA changed cytokine/chemokines mRNA profiles in lymphocytes; increased cytokines expression is via oxidative stress, p38MAPK, and PKC pathways. Diabetes is an…”
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Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding by Brishti, Masuma Akter, Raghavan, Somasundaram, Lamar, Kennedy, Singh, Udai P, Collier, Daniel M, Leo, M. Dennis

“…Soluble cell adhesion molecules (sCAMs) are secreted ectodomain fragments of surface adhesion molecules, ICAM1 and VCAM1. sCAMs have diverse immune functions…”
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Rab GTPases as Modulators of Vascular Function by Raghavan, Somasundaram, Brishti, Masuma Akter, Leo, M. Dennis

“…Rab GTPases, the largest family of small GTPases, are ubiquitously expressed proteins that control various aspects of cellular function, from cell survival to…”
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Cardiovascular Impacts on COVID-19 Infected Patients by Raghavan, Somasundaram, Gayathri, R, Kancharla, Sudhakar, Kolli, Prachetha, Ranjitha, J, Shankar, Vijayalakshmi

“…The SARS-CoV-2 virus has taken more than 2 million lives on a global scale. Over 10 million people were confirmed with COVID-19 infection. The well-known spot…”
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SARS‐CoV‐2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity by Raghavan, Somasundaram, Kenchappa, Divya, Leo, M.

“…Background SARS‐CoV‐2 enters cells through the Angiotensin‐converting enzyme 2 (ACE‐2) receptor present on the cell surface. ACE‐2 is present in many cell…”
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Engineering microbes for sustainable biofuel production and extraction of lipids – Current research and future perspectives by Joseph Antony Sundarsingh, T., Ameen, Fuad, Ranjitha, J., Raghavan, Somasundaram, Shankar, Vijayalakshmi

“…•Genetic modification of microbe for enhanced lipid production was studied in detail.•Extraction methods of lipid from genetic modified microbe was studied in…”
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Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK-PGC1α Signaling and Limits Oxygen Toxicity by Raghavan, Somasundaram, Kundumani-Sridharan, Venkatesh, Kumar, Sudhir, White, Carl W, Das, Kumuda C

“…Administration of high concentrations of oxygen (hyperoxia) is one of few available options to treat acute hypoxemia-related respiratory failure, as seen in…”
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TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes by Leo, M Dennis, Peixoto-Nieves, Dieniffer, Yin, Wen, Raghavan, Somasundaram, Muralidharan, Padmapriya, Mata-Daboin, Alejandro, Jaggar, Jonathan H

“…The pathological involvement of anion channels in vascular dysfunction that occurs during type 2 diabetes (T2D) is unclear. Here, we tested the hypothesis that…”
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Extracellular glucose and dysfunctional insulin receptor signaling independently upregulate arterial smooth muscle TMEM16A expression by Raghavan, Somasundaram, Brishti, Masuma Akter, Bernardelli, Angelica, Mata-Daboin, Alejandro, Jaggar, Jonathan H, Leo, M Dennis

“…Diabetes alters the function of ion channels responsible for regulating arterial smooth muscle membrane potential, resulting in vasoconstriction. Our prior…”
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Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis by Mandal, Mousumi, Rakib, Ahmed, Kiran, Sonia, Al Mamun, Md Abdullah, Raghavan, Somasundaram, Kumar, Santosh, Singla, Bhupesh, Park, Frank, Leo, M Dennis, Singh, Udai P

“…Interstitial cystitis (IC), also called painful bladder syndrome (PBS), is 2 to 5 times more common in women than in men, yet its cause and pathogenesis remain…”
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Response by Raghavan et al to Letter Regarding Article, “Protein Kinase Cθ via Activating Transcription Factor 2–Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis” by Raghavan, Somasundaram, Singh, Nikhlesh K, Gali, Sivaiah, Mani, Arul M, Rao, Gadiparthi N

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Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane by Kundumani-Sridharan, Venkatesh, Subramani, Jaganathan, Raghavan, Somasundaram, Maiti, Guru P, Owens, Cade, Walker, Trevor, Wasnick, John, Idell, Steven, Das, Kumuda C

“…High concentrations of oxygen (hyperoxia) are routinely used during anesthesia, and supplemental oxygen is also administered in connection with several other…”
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Response by Raghavan et al to Letter Regarding Article, "Protein Kinase Cθ via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C hi Cells Contributes to Atherosclerosis" by Raghavan, Somasundaram, Singh, Nikhlesh K, Gali, Sivaiah, Mani, Arul M, Rao, Gadiparthi N

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PKCθ via Activating Transcription Factor 2-mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis by Raghavan, Somasundaram, Singh, Nikhlesh K, Gali, Sivaiah, Mani, Arul M, Rao, Gadiparthi N

“…BACKGROUND:Although the role of thrombin in atherothrombosis is well studied, its role in the pathogenesis of diet-induced atherosclerosis is not known…”
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Protein Kinase Cθ Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis by Raghavan, Somasundaram, Singh, Nikhlesh K., Gali, Sivaiah, Mani, Arul M., Rao, Gadiparthi N.

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