Search Results - "Raftrey, Brian"
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Tissue-specific degradation of essential centrosome components reveals distinct microtubule populations at microtubule organizing centers
Published in PLoS biology (06-08-2018)“…Non-centrosomal microtubule organizing centers (ncMTOCs) are found in most differentiated cells, but how these structures regulate microtubule organization and…”
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2
Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size
Published in Development (Cambridge) (15-09-2017)“…How mechanotransduction intersects with chemical and transcriptional factors to shape organogenesis is an important question in developmental biology. This is…”
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3
DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis
Published in Genes & development (01-07-2017)“…Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms regulating their development are poorly understood. Many arteries,…”
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4
Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration
Published in eLife (08-11-2019)“…In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance…”
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Dach1 Extends Artery Networks and Protects Against Cardiac Injury
Published in Circulation research (17-09-2021)“…[Figure: see text]…”
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VEGF-C and aortic cardiomyocytes guide coronary artery stem development
Published in The Journal of clinical investigation (01-11-2014)“…Coronary arteries (CAs) stem from the aorta at 2 highly stereotyped locations, deviations from which can cause myocardial ischemia and death. CA stems form…”
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Epigenetic fun(ction) in the sun
Published in Developmental cell (27-09-2021)“…Tanning, or increased epidermal pigmentation, protects organisms from ultraviolet radiation (UV)-induced damages. In this issue of Development Cell, Li et al…”
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8
Single-cell analysis of early progenitor cells that build coronary arteries
Published in Nature (London) (01-07-2018)“…Arteries and veins are specified by antagonistic transcriptional programs. However, during development and regeneration, new arteries can arise from…”
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Specialized post-arterial capillaries facilitate adult bone remodelling
Published in Nature cell biology (11-11-2024)“…Abstract The vasculature of the skeletal system is crucial for bone formation, homoeostasis and fracture repair, yet the diversity and specialization of…”
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10
Dach1 Extends Artery Networks and Protects Against Cardiac Injury
Published in Circulation research (30-08-2021)Get full text
Journal Article -
11
Dach1 Regulates the Specification of Coronary Artery Endothelial Cells
Published 01-01-2021“…Cardiovascular disease (CVD) is the most common cause of death in the world and new treatments are needed to combat this disease. An unexplored approach to…”
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Dissertation