Search Results - "Rafiqi, Fatema H"

Activation of the thiazide-sensitive Na⁺-Cl⁻ cotransporter by the WNK-regulated kinases SPAK and OSR1 by Richardson, Ciaran, Rafiqi, Fatema H, Karlsson, Håkan K.R, Moleleki, Ntsane, Vandewalle, Alain, Campbell, David G, Morrice, Nick A, Alessi, Dario R

“…Mutations increasing WNK1 kinase expression in humans cause the pseudohypoaldosteronism type II hypertension syndrome. This condition is treated effectively by…”
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SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation by Thastrup, Jacob O, Rafiqi, Fatema H, Vitari, Alberto C, Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R

“…Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has…”
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Role of the WNK‐activated SPAK kinase in regulating blood pressure by Rafiqi, Fatema H., Zuber, Annie Mercier, Glover, Mark, Richardson, Ciaran, Fleming, Stewart, Jovanović, Sofija, Jovanović, Aleksandar, O'Shaughnessy, Kevin M., Alessi, Dario R.

“…Mutations within the with‐no‐K(Lys) (WNK) kinases cause Gordon's syndrome characterized by hypertension and hyperkalaemia. WNK kinases phosphorylate and…”
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Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway by San-Cristobal, Pedro, Pacheco-Alvarez, Diana, Richardson, Ciaran, Ring, Aaron M, Vazquez, Norma, Rafiqi, Fatema H, Chari, Divya, Kahle, Kristopher T, Leng, Qiang, Bobadilla, Norma A, Hebert, Steven C, Alessi, Dario R, Lifton, Richard P, Gamba, Gerardo

“…Mutations in the kinase WNK4 cause pseudohypoaldosteronism type II (PHAII), a syndrome featuring hypertension and high serum K⁺ levels (hyperkalemia). WNK4 has…”
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Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 by Vitari, Alberto C, Thastrup, Jacob, Rafiqi, Fatema H, Deak, Maria, Morrice, Nick A, Karlsson, Håkan K R, Alessi, Dario R

“…The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na+-K+-2Cl-…”
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Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade by Chiga, Motoko, Rafiqi, Fatema H, Alessi, Dario R, Sohara, Eisei, Ohta, Akihito, Rai, Tatemitsu, Sasaki, Sei, Uchida, Shinichi

“…We recently reported increased phosphorylation of the NaCl cotransporter (NCC) in Wnk4(D561A/+) knock-in mice, an ideal model of the human hereditary…”
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Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress by Zagórska, Anna, Pozo-Guisado, Eulalia, Boudeau, Jérôme, Vitari, Alberto C, Rafiqi, Fatema H, Thastrup, Jacob, Deak, Maria, Campbell, David G, Morrice, Nick A, Prescott, Alan R, Alessi, Dario R

“…Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated. We demonstrate that…”
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SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl− Cotransporter 2 by Reiche, Juliane, Theilig, Franziska, Rafiqi, Fatema H., Carlo, Anne-Sophie, Militz, Daniel, Mutig, Kerim, Todiras, Mihail, Christensen, Erik Ilsø, Ellison, David H., Bader, Michael, Nykjaer, Anders, Bachmann, Sebastian, Alessi, Dario, Willnow, Thomas E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PDCD4 Is an Androgen-Repressed Tumor Suppressor that Regulates Prostate Cancer Growth and Castration Resistance by Zennami, Kenji, Choi, Su Mi, Liao, Ross, Li, Ying, Dinalankara, Wikum, Marchionni, Luigi, Rafiqi, Fatema H, Kurozumi, Akira, Hatano, Koji, Lupold, Shawn E

“…Androgen receptor (AR) transcriptional activity contributes to prostate cancer development and castration resistance. The growth and survival pathways driven…”
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Structural insights into the recognition of substrates and activators by the OSR1 kinase by Villa, Fabrizio, Goebel, Jürgen, Rafiqi, Fatema H, Deak, Maria, Thastrup, Jacob, Alessi, Dario R, van Aalten, Daan M F

“…The oxidative‐stress‐responsive kinase 1 (OSR1) and the STE20/SPS1‐related proline/alanine‐rich kinase (SPAK) are key enzymes in a signalling cascade…”
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