Search Results - "Rafidi, Hanine"

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies by Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew

“…Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for biologic…”
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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics by Shivva, Vittal, Boswell, C. Andrew, Rafidi, Hanine, Kelley, Robert F., Kamath, Amrita V., Crowell, Susan R.

“…Protein therapeutics have witnessed tremendous use and application in recent years in treatment of various diseases. Predicting efficacy and safety during drug…”
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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response by Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T, Pillow, Thomas H, Phillips, Gail D, Rowntree, Rebecca K, Boswell, C Andrew, Kozak, Katherine R, Polson, Andrew G, Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S, Agard, Nicholas J

“…Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug…”
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Preclinical evaluation of antisense-oligonucleotide (ASO) brain distribution using PET and SPECT imaging post intrathecal injection by Rafidi, Hanine, Marik, Jan

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Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid by Sadekar, Shraddha S., Bowen, Mayumi, Cai, Hao, Jamalian, Samira, Rafidi, Hanine, Shatz‐Binder, Whitney, Lafrance‐Vanasse, Julien, Chan, Pamela, Meilandt, William J., Oldendorp, Amy, Sreedhara, Alavattam, Daugherty, Ann, Crowell, Susan, Wildsmith, Kristin R., Atwal, Jasvinder, Fuji, Reina N., Horvath, Joshua

“…Delivery of biologics via cerebrospinal fluid (CSF) has demonstrated potential to access the tissues of the central nervous system (CNS) by circumventing the…”
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy by Adhikari, Pragya, Li, Guangmin, Go, MaryAnn, Mandikian, Danielle, Rafidi, Hanine, Ng, Carl, Anifa, Sagana, Johnson, Kevin, Bao, Linda, Hernandez Barry, Hilda, Rowntree, Rebecca, Agard, Nicholas, Wu, Cong, Chou, Kang-Jye, Zhang, Donglu, Kozak, Katherine R., Pillow, Thomas H., Lewis, Gail D., Yu, Shang-Fan, Boswell, C. Andrew, Sadowsky, Jack D.

“…Antibody-drug conjugates (ADCs) for the treatment of cancer aim to achieve selective delivery of a cytotoxic payload to tumor cells while sparing normal…”
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Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics by Rafidi, Hanine, Estevez, Alberto, Ferl, Gregory Z, Mandikian, Danielle, Stainton, Shannon, Sermeño, Lauren, Williams, Simon P, Kamath, Amrita V, Koerber, James T, Boswell, C Andrew

“…Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for cancer…”
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Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies by Nazarova, Lidia, Rafidi, Hanine, Mandikian, Danielle, Ferl, Gregory Z, Koerber, James T, Davies, Christopher W, Ulufatu, Sheila, Ho, Jason, Lau, Jeffrey, Yu, Shang-Fan, Ernst, James, Sadowsky, Jack D, Boswell, C Andrew

“…Full-length antibodies lack ideal pharmacokinetic properties for rapid targeted imaging, prompting the pursuit of smaller peptides and fragments. Nevertheless,…”
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The Role of a Second Shell Hydrophobic Interaction in Trypsin‐Fold Serine Protease Function by Batt, Anna, Rafidi, Hanine, Baird, Teaster

“…Abstract only In several co‐crystal structures of trypsin and its macromolecular inhibitors, the backbone carbonyl of Phe 41 accepts a hydrogen bond from the…”
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The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3 by Hatakeyama, Jason, Wald, Jessica H, Rafidi, Hanine, Cuevas, Antonio, Sweeney, Colleen, Carraway, 3rd, Kermit L

“…ErbB3 and ErbB4 are receptor tyrosine kinases that are activated by the neuregulin (NRG) family of growth factors. These receptors govern various developmental…”
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Abstract 32: The role of Lrig1 signaling in mammary gland development and tumorigenesis by Simion, Catalina, Chen, Qian J., Wilkerson, Charles L., Rafidi, Hanine, Borowsky, Alexander D., Sweeney, Colleen

“…Abstract Lrig1 is a transmembrane leucine-rich repeat protein and a negative regulator of oncogenic receptor tyrosine kinases (RTKs) such as the ErbB family…”
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Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology by Mandikian, Danielle, Figueroa, Isabel, Oldendorp, Amy, Rafidi, Hanine, Ulufatu, Sheila, Schweiger, Michelle G., Couch, Jessica A., Dybdal, Noel, Joseph, Sean B., Prabhu, Saileta, Ferl, Gregory Z., Boswell, C. Andrew

“…We previously performed a comparative assessment of tissue-level vascular physiological parameters in mice and rats, two of the most commonly utilized species…”
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Leucine-rich Repeat and Immunoglobulin Domain-containing Protein-1 (Lrig1) Negative Regulatory Action toward ErbB Receptor Tyrosine Kinases Is Opposed by Leucine-rich Repeat and Immunoglobulin Domain-containing Protein 3 (Lrig3) by Rafidi, Hanine, Mercado, Francisco, Astudillo, Michael, Fry, William H.D., Saldana, Matthew, Carraway, Kermit L., Sweeney, Colleen

“…Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3. Lrig1 is a negative…”
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Lrig1 is an estrogen-regulated growth suppressor and correlates with longer relapse-free survival in ERα-positive breast cancer by Krig, Sheryl R, Frietze, Seth, Simion, Catalina, Miller, Jamie K, Fry, Will H D, Rafidi, Hanine, Kotelawala, Lakmal, Qi, Lihong, Griffith, Obi L, Gray, Joe W, Carraway, 3rd, Kermit L, Sweeney, Colleen

“…Lrig1 is the founding member of the Lrig family and has been implicated in the negative regulation of several oncogenic receptor tyrosine kinases including…”
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Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging by Mandikian, Danielle, Rafidi, Hanine, Adhikari, Pragya, Venkatraman, Priya, Nazarova, Lidia, Fung, Gabriel, Figueroa, Isabel, Ferl, Gregory Z, Ulufatu, Sheila, Ho, Jason, McCaughey, Cynthia, Lau, Jeffrey, Yu, Shang-Fan, Prabhu, Saileta, Sadowsky, Jack, Boswell, C Andrew

“…Antibody pretargeting is a promising strategy for improving molecular imaging, wherein the separation in time of antibody targeting and radiolabeling can lead…”
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Lrig1 Negative Regulatory Activity Towards ErbB Receptors is Opposed by Lrig3 by Rafidi, Hanine

“…Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3. Lrig1 is a negative…”
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Lrig1 Negative Regulatory Activity Towards ErbB Receptors is Opposed by Lrig3 by Rafidi, Hanine

“…Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3. Lrig1 is a negative…”
Get full text

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies by Rafidi, Hanine, Rajan, Sharmila, Urban, Konnie, Shatz-Binder, Whitney, Hui, Keliana, Ferl, Gregory Z., Kamath, Amrita V., Boswell, C. Andrew

“…Advances in antibody engineering have enabled the construction of novel molecular formats in diverse shapes and sizes, providing new opportunities for biologic…”
Get full text

Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response by Dela Cruz Chuh, Josefa, Go, MaryAnn, Chen, Yvonne, Guo, Jun, Rafidi, Hanine, Mandikian, Danielle, Sun, Yonglian, Lin, Zhonghua, Schneider, Kellen, Zhang, Pamela, Vij, Rajesh, Sharpnack, Danielle, Chan, Pamela, de la Cruz, Cecile, Sadowsky, Jack, Seshasayee, Dhaya, Koerber, James T., Pillow, Thomas H., Phillips, Gail D., Rowntree, Rebecca K, Boswell, C. Andrew, Kozak, Katherine R., Polson, Andrew G., Polakis, Paul, Yu, Shang-Fan, Dragovich, Peter S., Agard, Nicholas J.

“…Early success with brentuximab vedotin in treating classical Hodgkin lymphoma spurred an influx of at least 20 monomethyl auristatin E (MMAE) antibody-drug…”
Get full text

Site-specific conjugation allows modulation of click reaction stoichiometry for pretargeted SPECT imaging by Mandikian, Danielle, Rafidi, Hanine, Adhikari, Pragya, Venkatraman, Priya, Nazarova, Lidia, Fung, Gabriel, Figueroa, Isabel, Ferl, Gregory Z., Ulufatu, Sheila, Ho, Jason, McCaughey, Cynthia, Lau, Jeffrey, Yu, Shang-Fan, Prabhu, Saileta, Sadowsky, Jack, Boswell, C. Andrew

“…Antibody pretargeting is a promising strategy for improving molecular imaging, wherein the separation in time of antibody targeting and radiolabeling can lead…”
Get full text