Search Results - "Raffin, Caroline"

Treg cell-based therapies: challenges and perspectives by Raffin, Caroline, Vo, Linda T., Bluestone, Jeffrey A.

“…Cellular therapies using regulatory T (T reg ) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection…”
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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 by Muller, Yannick D, Nguyen, Duy P, Ferreira, Leonardo M R, Ho, Patrick, Raffin, Caroline, Valencia, Roxxana Valeria Beltran, Congrave-Wilson, Zion, Roth, Theodore L, Eyquem, Justin, Van Gool, Frederic, Marson, Alexander, Perez, Laurent, Wells, James A, Bluestone, Jeffrey A, Tang, Qizhi

“…Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the…”
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MHC class II/ESO tetramer-based generation of in vitro primed anti-tumor T-helper lines for adoptive cell therapy of cancer by Poli, Caroline, Raffin, Caroline, Dojcinovic, Danijel, Luescher, Immanuel, Ayyoub, Maha, Valmori, Danila

“…Generation of tumor-antigen specific CD4(+) T-helper (T(H)) lines through in vitro priming is of interest for adoptive cell therapy of cancer, but the…”
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Human RORγt⁺ TH17 cells preferentially differentiate from naive FOXP3⁺Treg in the presence of lineage-specific polarizing factors by Valmori, Danila, Raffin, Caroline, Raimbaud, Isabelle, Ayyoub, Maha

“…RORγt⁺ TH17 cells are a proinflammatory CD4⁺ T-cell population associated with autoimmune tissue injury. In mice, priming of TH17 requires TGF-β, which alone…”
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T reg cell-based therapies: challenges and perspectives by Raffin, Caroline, Vo, Linda T, Bluestone, Jeffrey A

“…Cellular therapies using regulatory T (T ) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and…”
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CXCR3+ T Regulatory Cells Selectively Accumulate in Human Ovarian Carcinomas to Limit Type I Immunity by REDJIMI, Nassima, RAFFIN, Caroline, RAIMBAUD, Isabelle, PIGNON, Pascale, MATSUZAKI, Junko, ODUNSI, Kunle, VALMORI, Danila, AYYOUB, Maha

“…Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of…”
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T.sub.reg cell-based therapies: challenges and perspectives by Raffin, Caroline, Vo, Linda T, Bluestone, Jeffrey A

“…Cellular therapies using regulatory T (T.sub.reg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection…”
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Human memory Helios- FOXP3+ regulatory T cells (Tregs) encompass induced Tregs that express Aiolos and respond to IL-1β by downregulating their suppressor functions by Raffin, Caroline, Pignon, Pascale, Celse, Clotilde, Debien, Emilie, Valmori, Danila, Ayyoub, Maha

“…FOXP3(+) regulatory T cells (Tregs) are critical regulators of self-tolerance and immune homeostasis. In mice and humans, two subsets of FOXP3(+) Tregs have…”
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Comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans" by Ayyoub, Maha, Raffin, Caroline, Valmori, Danila

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Ex vivo IL-1 receptor type I expression in human CD4+ T cells identifies an early intermediate in the differentiation of Th17 from FOXP3+ naive regulatory T cells by Raffin, Caroline, Raimbaud, Isabelle, Valmori, Danila, Ayyoub, Maha

“…IL-17-producing CD4(+) Th (Th17) cells are a unique subset of proinflammatory cells expressing the retinoic acid-related orphan receptor γt and associated with…”
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Generation of Th17 from human naive CD4+ T cells preferentially occurs from FOXP3+ Tregs upon costimulation via CD28 or CD5 by Ayyoub, Maha, Raffin, Caroline, Valmori, Danila

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Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis by Raffin, Caroline, Zhou, Yu, Piccoli, Luca, Lanzavecchia, Antonio, Sadelain, Michel, Tareen, Semih U., Fontenot, Jason D., Bluestone, Jeffrey A.

“…Abstract Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases that is characterized by an aberrant inflammation of the synovial…”
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Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis by Raffin, Caroline, Muller, Yannick, Barragan, Jessica, Zhou, Yu, Piccoli, Luca, Lanzavecchia, Antonio, Tareen, Semih U, Fontenot, Jason D, Bluestone, Jeffrey A

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an aberrant inflammation of the synovial membrane that causes irreversible…”
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Development of citrullinated-vimentin-specific CAR for targeting Tregs to treat autoimmune rheumatoid arthritis by Raffin, Caroline, Zhou, Yu, Piccoli, Luca, Lanzavecchia, Antonio, Sadelain, Michel, Bluestone, Jeffrey A

“…Abstract Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases with a frequency of 0.5–1.0% in the adult population of developed…”
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Natural CXCR3+ FOXP3+ Treg selectively accumulate in human ovarian carcinomas to control type I immunity (127.27) by Raffin, Caroline, Redjimi, Nassima, Odunsi, Kunle, Valmori, Danila, Ayyoub, Maha

“…Abstract Anti-tumor type I T cell responses are critical to control cancer but their efficacy is limited by immunoregulatory mechanisms, including the action…”
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Human ROR[gamma]t+ T^sub H^17 cells preferentially differentiate from naive FOXP3+Treg in the presence of lineage-specific polarizing factors by Valmori, Danila, Raffin, Caroline, Raimbaud, Isabelle, Ayyoub, Maha

“…ROR...t... T...17 cells are a proinflammatory CD4... T-cell population associated with autoimmune tissue injury. In mice, priming of T...17 requires TGF-β,…”
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Human RORγt + T H 17 cells preferentially differentiate from naive FOXP3 + Treg in the presence of lineage-specific polarizing factors by Valmori, Danila, Raffin, Caroline, Raimbaud, Isabelle, Ayyoub, Maha

“…RORγt + T H 17 cells are a proinflammatory CD4 + T-cell population associated with autoimmune tissue injury. In mice, priming of T H 17 requires TGF-β, which…”
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