Search Results - "Raffenne, Jerôme"

Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome by Laouirem, Samira, Sannier, Aurélie, Norkowski, Emma, Cauchy, François, Doblas, Sabrina, Rautou, Pierre Emmanuel, Albuquerque, Miguel, Garteiser, Philippe, Sognigbé, Laura, Raffenne, Jerôme, van Beers, Bernard E., Soubrane, Olivier, Bedossa, Pierre, Cros, Jerôme, Paradis, Valérie

“…Metabolic syndrome (MS) is becoming the leading risk factor for hepatocellular carcinoma (HCC). HCC development related to MS may occur in advanced or…”
Get full text

Role of the fatty pancreatic infiltration in pancreatic oncogenesis by Frendi, Sonia, Martineau, Chloé, Cazier, Hélène, Nicolle, Rémy, Chassac, Anaïs, Albuquerque, Miguel, Raffenne, Jérôme, Le Faouder, Julie, Paradis, Valérie, Cros, Jérôme, Couvelard, Anne, Rebours, Vinciane

“…Although pancreatic precancerous lesions are known to be related to obesity and fatty pancreatic infiltration, the mechanisms remain unclear. We assessed the…”
Get full text

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma by Neuzillet, Cindy, Nicolle, Rémy, Raffenne, Jérôme, Tijeras‐Raballand, Annemilaï, Brunel, Alexia, Astorgues‐Xerri, Lucile, Vacher, Sophie, Arbateraz, Floriane, Fanjul, Marjorie, Hilmi, Marc, Samain, Rémi, Klein, Christophe, Perraud, Aurélie, Rebours, Vinciane, Mathonnet, Muriel, Bièche, Ivan, Kocher, Hemant, Cros, Jérôme, Bousquet, Corinne

“…Cancer‐associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF…”
Get full text

Borderline Hepatocellular Adenomas: A Practical Diagnostic Approach Based on Pathologic and Molecular Features by Poté, Nicolas, Caruso, Stefano, Caderaro, Julien, Cauchy, François, Lagadec, Floriane, Couchy, Gabrielle, Raffenne, Jérôme, Augustin, Jeremy, Vernuccio, Federica, Vilgrain, Valérie, Hercent, Agathe, Theou-Anton, Nathalie, Zucman-Rossi, Jessica, Paradis, Valérie

“…Borderline hepatocellular adenomas (BL-HCA) are characterized by focal architectural/cytologic atypia and reticulin loss, features that are insufficient for a…”
Get full text

Oenococcus oeni Exopolysaccharide Biosynthesis, a Tool to Improve Malolactic Starter Performance by Dimopoulou, Maria, Raffenne, Jerôme, Claisse, Olivier, Miot-Sertier, Cécile, Iturmendi, Nerea, Moine, Virginie, Coulon, Joana, Dols-Lafargue, Marguerite

“…is the lactic acid bacterium that most commonly drives malolactic fermentation (MLF) in wine. Though the importance of MLF in terms of wine microbial stability…”
Get full text

The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma by Poté, Nicolas, Cros, Jérôme, Laouirem, Samira, Raffenne, Jérôme, Negrão, Magda, Albuquerque, Miguel, Bedossa, Pierre, Godinho Ferreira, Miguel, Ait Si Ali, Slimane, Fior, Rita, Paradis, Valérie

“…Background & Aims Vascular invasion is a major prognostic factor in hepatocellular carcinoma (HCC). We previously identified histone H4 acetylated at lysine 16…”
Get full text

Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features by Raffenne, Jérôme, Martin, Fernando A, Nicolle, Rémy, Konta, Marina, Blum, Yuna, Torrisani, Jérôme, Puleo, Francesco, Bachet, Jean Baptiste, Svrcek, Magali, Bardier-Dupas, Armel, Emile, Jean Francois, Demetter, Peter, Radman, Miroslav, Van Laethem, Jean Luc, Hammel, Pascal, Rebours, Vinciane, Paradis, Valérie, Couvelard, Anne, Cros, Jérôme

“…Pancreatic ducal adenocarcinoma is classically diagnosed in the 7th decade, but approximately 10% of patients are diagnosed under 55 years (y.o.). While the…”
Get full text

Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages by Samain, Rémi, Brunel, Alexia, Douché, Thibault, Fanjul, Marjorie, Cassant-Sourdy, Stéphanie, Rochotte, Julia, Cros, Jérôme, Neuzillet, Cindy, Raffenne, Jérôme, Duluc, Camille, Perraud, Aurélie, Nigri, Jérémy, Gigoux, Véronique, Bieche, Ivan, Ponzo, Matteo, Carpentier, Gilles, Cascone, Ilaria, Tomasini, Richard, Schmid, Herbert A., Mathonnet, Muriel, Nicolle, Rémy, Bousquet, Marie-Pierre, Martineau, Yvan, Pyronnet, Stéphane, Jean, Christine, Bousquet, Corinne

“…Cancer-associated fibroblasts (CAFs) from pancreatic adenocarcinoma (PDA) present high protein synthesis rates. CAFs express the G-protein–coupled somatostatin…”
Get full text

Abstract PO-088: Classification based on efficiency of mRNA translation reveals a metabolically-dependent subtype of pancreatic cancer by Shin, Sauyeun, Nicolle, Remy, Liauzun, Mehdi, Solorzano, Jacobo, Brunel, Alexia, Jean, Christine, Samain, Remi, Raffenne, Jerôme, Neuzillet, Cindy, Joffre, Carine, Rocci, Stephane, Iovanna, Juan, Dusetti, Nelson, Larsson, Ola, Pyronnet, Stephane, Bousquet, Corinne, Martineau, Yvan

“…Molecular profiling of Pancreatic Ductal Adenocarcinoma (PDA), based on transcriptomic analyses, identifies two main prognostic subtypes (basal-like and…”
Get full text

Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis by Di Carlo, Selene E., Raffenne, Jerome, Varet, Hugo, Ode, Anais, Granados, David Cabrerizo, Stein, Merle, Legendre, Rachel, Tuckermann, Jan, Bousquet, Corinne, Peduto, Lucie

“…The capacity to survive and thrive in conditions of limited resources and high inflammation is a major driver of tumor malignancy. Here we identified…”
Get full text

Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset by Nicolle, Remy, Raffenne, Jerome, Paradis, Valerie, Couvelard, Anne, de Reynies, Aurelien, Blum, Yuna, Cros, Jerome

“…Data from the Cancer Genome Atlas (TCGA) are now easily accessible through web-based platforms with tools to assess the prognostic value of molecular…”
Get full text

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma by Neuzillet, Cindy, Nicolle, Rémy, Raffenne, Jérôme, Tijeras-Raballand, Annemilaï, Brunel, Alexia, Astorgues-Xerri, Lucile, Vacher, Sophie, Arbateraz, Floriane, Fanjul, Marjorie, Hilmi, Marc, Samain, Rémi, Klein, Christophe, Perraud, Aurélie, Rebours, Vinciane, Mathonnet, Muriel, Bièche, Ivan, Kocher, Hemant, Cros, Jérôme, Bousquet, Corinne

“…Abstract Cancer‐associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four…”
Get full text

La caractérisation moléculaire définit plusieurs sous-types d’adénocarcinome canalaire du pancréas by Raffenne, Jérôme, Cros, Jérôme

“…Les analyses à haut débit appliquées à l’adénocarcinome pancréatique ont permis de décrire plusieurs sous-types moléculaires ayant pour la plupart des…”
Get full text

hENT1 Testing in Pancreatic Ductal Adenocarcinoma: Are We Ready? A Multimodal Evaluation of hENT1 Status by Raffenne, Jerome, Nicolle, Remy, Puleo, Francesco, Le Corre, Delphine, Boyez, Camille, Marechal, Raphael, Emile, Jean François, Demetter, Peter, Bardier, Armelle, Laurent-Puig, Pierre, de Mestier, Louis, Paradis, Valerie, Couvelard, Anne, VanLathem, Jean Luc, MacKey, John R, Bachet, Jean-Baptiste, Svrcek, Magali, Cros, Jerome

“…Gemcitabine is still one of the standard chemotherapy regimens for pancreatic ductal adenocarcinoma (PDAC). Gemcitabine uptake into tumor cells is mainly…”
Get full text

Gly388Arg FGFR4 Polymorphism Is Not Predictive of Everolimus Efficacy in Well-Differentiated Digestive Neuroendocrine Tumors by Cros, Jerome, Moati, Emilie, Raffenne, Jerome, Hentic, Olivia, Svrcek, Magali, de Mestier, Louis, Sbidian, Emilie, Guedj, Nathalie, Bedossa, Pierre, Paradis, Valerie, Sauvanet, Alain, Panis, Yves, Ruszniewski, Philippe, Couvelard, Anne, Hammel, Pascal

“…Preclinical data suggest that the single nucleotide polymorphism substituting a glycine for an arginine in codon 388 of the FGFR4 transmembrane domain may…”
Get more information

Abstract C034: Bioinformatical identification of cancer-associated-fibroblasts with tumor cells pro-migratory crosstalks depending on activin by Brunel, Alexia, Raffenne, Jérôme, Nicolle, Remy, Rooman, Ilse, Espinet, Elisa, Fanjul, Marjorie, Perraud, Aurélie, Mathonnet, Muriel, Vasseur, Sophie, Dusetti, Nelson, Martineau, Yvan, Jean, Christine, Bousquet, Corinne

“…Pancreatic ductal adenocarcinoma (PDAC) aggressiveness results from its high metastatic and chemoresistance potential. Pancreatic cancer cells are immersed in…”
Get full text

Exopolysaccharide biosynthesis, a tool to improve malolactic starter performance by Dimopoulou, Maria, Raffenne, Jérôme, Claisse, Olivier, Miot-Sertier, Cecile, Iturmendi, Nerea, Moine, Virginie, Coulon, Joana, Dols-Lafargue, Marguerite

“…Oenococcus oeni is the lactic acid bacterium that most commonly drives malolactic fermentation (MLF) in wine. Though the importance of MLF in terms of wine…”
Get full text

High PRDX3 expression is associated with pancreatic adenocarcinoma aggressiveness and can be targeted by a novel therapeutic strategy by Raffenne, Jerome, Martin, Fernando A., Conta, Marina, Sauvanet, Alain, Hammel, Pascal, Bedossa, Pierre, Paradis, Valerie, Couvelard, Anne, Cros, Jerome

Get full text

Abstract 794: Prognostic value of high c-Met expression in patients with poor prognosis pancreatic adenocarcinoma following surgical resection: comparison of three c-Met scoring methods and exploration of underlying mechanisms of c-Met overexpression by Neuzillet, Cindy, Tijeras-Raballand, Annemilaï, Raffenne, Jérôme, de Gramont, Armand, Bedossa, Pierre, Paradis, Valérie, Sauvanet, Alain, Bachet, Jean-Baptiste, Raymond, Eric, Hammel, Pascal, Couvelard, Anne, Cros, Jérôme

“…Context: The HGF/c-Met pathway is an hypoxia-inducible pathway involved in tumor-stroma interactions and invasion in pancreatic ductal adenocarcinoma (PDAC)…”
Get full text

Genomic and transcriptomic characterization of aggressive well differentiated pancreatic neuroendocrine tumors by Cros, Jerome, Soukeur, M'Barka, Raffenne, Jerome, Bernard, Virginie, Marinoni, Ilaria, Dumont, Florent, De Koning, Leanne, Scoazec, Jean Yves, Svrcek, Magali, Hentic, Olivia, Sauvanet, Alain, Levy, Philippe, Paradis, Valerie, Bieche, Ivan, Ruszniewski, Philippe, Couvelard, Anne

Get full text