Search Results - "Raffaelli, N."

Enzymology of NAD+ homeostasis in man by Magni, G, Amici, A, Emanuelli, M, Orsomando, G, Raffaelli, N, Ruggieri, S

“…This review describes the enzymes involved in human pyridine nucleotide metabolism starting with a detailed consideration of their major kinetic, molecular and…”
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NAD(P) biosynthesis enzymes as potential targets for selective drug design by Magni, G, Di Stefano, M, Orsomando, G, Raffaelli, N, Ruggieri, S

“…NAD(P) biosynthetic pathways can be considered a generous source of enzymatic targets for drug development. Key reactions for NAD(P) biosynthesis in all…”
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Structure and function of nicotinamide mononucleotide adenylyltransferase by Magni, G, Amici, A, Emanuelli, M, Orsomando, G, Raffaelli, N, Ruggieri, S

“…The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT), a member of the nucleotidyltransferase alpha/beta phosphodiesterase superfamily, catalyzes…”
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Evidence for essential catalytic determinants for human erythrocyte pyrimidine 5'-nucleotidase by Amici, A, Ciccioli, K, Naponelli, V, Raffaelli, N, Magni, G

“…Human erythrocyte pyrimidine 5'-nucleotidase, PN-I, catalyzes the dephosphorylation of pyrimidine nucleoside monophosphates. The enzyme also possesses…”
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Nicotinamide-mononucleotide adenylyltransferase from Sulfolobus solfataricus by Raffaelli, N, Lorenzi, T, Emanuelli, M, Amici, A, Ruggieri, S, Magni, G

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SYNTHESIS AND BIOLOGICAL EVALUATION OF NAD ANALOGS AS HUMAN PYRIDINE NUCLEOTIDE ADENYLYLTRANSFERASE INHIBITORS by Franchetti, Palmarisa, Petrelli, R., Cappellacci, L., Pasqualini, M., Vita, P., Sorci, L., Mazzola, F., Raffaelli, N., Magni, Giulio

“…NAD analogs modified at the ribose adenylyl moiety, named N-2′-MeAD and Na-2′-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN)…”
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Characterization of nicotinamide mononucleotide adenylyltransferase from thermophilic archaea by Raffaelli, N, Pisani, F M, Lorenzi, T, Emanuelli, M, Amici, A, Ruggieri, S, Magni, G

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Assay Methods for Nicotinamide Mononucleotide Adenylyltransferase of Wide Applicability by Balducci, E., Emanuelli, M., Raffaelli, N., Ruggieri, S., Amici, A., Magni, G., Orsomando, G., Polzonetti, V., Natalini, P.

“…MMN adenylyltransferase (NMNAT) reversibly catalyzes the synthesis of NAD+ or NaAD+ from ATP and NMN or NaMN. In this work, we describe a continuous coupled…”
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Dinucleoside Polyphosphate NAD Analogs as Potential NMN Adenylyltransferase Inhibitors. Synthesis and Biological Evaluation by Franchetti, P., Cappellacci, L., Pasqualini, M., Grifantini, M., Lorenzi, T., Raffaelli, N., Magni, G.

“…Two dinucleoside polyphosphate NAD analogs, P 1 -(adenosine-5′)-P 3 -(nicotinamide riboside-5′)triphosphate (Np 3 A, 1) and P 1 -(adenosine-5′)-P 4…”
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Comment on Clinical and Prognostic Relevance of Ret-PTC Activation in Patients with Papillary Thyroid Carcinoma by Cetta, F, Gori, M, Raffaelli, N, Baldi, C, Montalto, G

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Nicotinamide-mononucleotide adenylyltransferase from Methanococcus jannaschii by Raffaelli, N, Pisani, F M, Lorenzi, T, Emanuelli, M, Amici, A, Ruggieri, S, Magni, G

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Homogeneous pyrimidine nucleotidase from human erythrocytes: enzymic and molecular properties by Amici, A, Emanuelli, M, Ferretti, E, Raffaelli, N, Ruggieri, S, Magni, G

“…A pyrimidine nucleotidase with unique specificity has been obtained for the first time as an homogeneous protein from the cytosolic fraction of human…”
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RET/PTC and RET Tyrosine Kinase Expression in Adult Papillary Thyroid Carcinomas—Authors’ Response by Cetta, F, Gori, M, Raffaelli, N, Baldi, C, Montalto, G, Learoyd, Diana L, Robinson, Bruce G

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NMN adenylyltransferase from bull testis: purification and properties by Balducci, E, Orsomando, G, Polzonetti, V, Vita, A, Emanuelli, M, Raffaelli, N, Ruggieri, S, Magni, G, Natalini, P

“…The purification procedure of NMN adenylyltransferase from bull testis presented here consists of a heat step and an acidic precipitation followed by four…”
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Glioma Cells Induce γ-Glutamyl Transpeptidase Activity in Cultured Blood but Not Lymphatic Endothelial Cells by Weber, E., Lorenzoni, P., Raffaelli, N., Cavina, N., Sacchi, G.

“…Glial cells have been shown to induce enzyme activities, which are characteristically high in brain capillaries, in cerebral and non cerebral endothelial cells…”
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Nuclear matrix-associated NMN adenylyltransferase activity in human placenta by Balducci, E, Emanuelli, M, Magni, G, Raffaelli, N, Ruggieri, S, Vita, A, Natalini, P

“…This paper presents data about the presence of the NMN adenylyltransferase at the nuclear matrix level of human placenta nuclei. It was found that 40-45% of…”
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One-minute high-performance liquid chromatography assay for 5'-nucleotidase using a 20-mm reverse-phase column by Amici, A, Emanuelli, M, Raffaelli, N, Ruggieri, S, Magni, G

“…A general procedure is described for developing HPLC-based assays for nucleotidases by using a 20-mm C-18 reversed-phase column. The method is applied on the…”
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Discovery of novel inhibitors of bacterial biofilm formation targeting enzymes involved in the metabolism of the second messenger cyclic-di-GMP by Antoniani, D., Bocci, P., Raffaelli, N., Landini, P.

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Identification of a novel human nicotinamide mononucleotide adenylyltransferase by Raffaelli, Nadia, Sorci, Leonardo, Amici, Adolfo, Emanuelli, Monica, Mazzola, Francesca, Magni, Giulio

“…The enzyme nicotinamide mononucleotide adenylyltransferase is an ubiquitous enzyme catalyzing an essential step in NAD (NADP) biosynthetic pathway. In human…”
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A Novel Fold Revealed by Mycobacterium tuberculosis NAD Kinase, a Key Allosteric Enzyme in NADP Biosynthesis by Garavaglia, Silvia, Raffaelli, Nadia, Finaurini, Lucia, Magni, Giulio, Rizzi, Menico

“…NAD kinase catalyzes the magnesium-dependent phosphorylation of NAD, representing the sole source of freshly synthesized NADP in all organisms. The enzyme is…”
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