Search Results - "Raff, Jordan W"

Phase Separation and the Centrosome: A Fait Accompli? by Raff, Jordan W.

“…There is currently intense interest in the idea that many membraneless organelles might assemble through phase separation of their constituent molecules into…”
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Centrosome function and assembly in animal cells by Conduit, Paul T., Wainman, Alan, Raff, Jordan W.

“…Key Points Centrosomes are not essential for cell division in most animal cells, although they contribute to the efficiency of mitotic spindle assembly…”
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Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes by Novak, Zsofia A., Wainman, Alan, Gartenmann, Lisa, Raff, Jordan W.

“…Centrosomes and cilia are organized by a centriole pair comprising an older mother and a younger daughter. Centriole numbers are tightly regulated, and…”
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The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation by Conduit, Paul T., Feng, Zhe, Richens, Jennifer H., Baumbach, Janina, Wainman, Alan, Bakshi, Suruchi D., Dobbelaere, Jeroen, Johnson, Steven, Lea, Susan M., Raff, Jordan W.

“…Centrosomes are important cell organizers. They consist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically during…”
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Cnn Dynamics Drive Centrosome Size Asymmetry to Ensure Daughter Centriole Retention in Drosophila Neuroblasts by Conduit, Paul T., Raff, Jordan W.

“…Centrosomes comprise a pair of centrioles surrounded by an amorphous network of pericentriolar material (PCM). In certain stem cells, the two centrosomes…”
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A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly by Wilmott, Zachary M, Goriely, Alain, Raff, Jordan W

“…Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole…”
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Centrosome Amplification and Cancer: A Question of Sufficiency by Raff, Jordan W., Basto, Renata

“…Centrosome amplification is a common feature of many types of cancer, but whether it is a cause or consequence is hotly debated. In this issue of Developmental…”
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Structural Basis for Mitotic Centrosome Assembly in Flies by Feng, Zhe, Caballe, Anna, Wainman, Alan, Johnson, Steven, Haensele, Andreas F.M., Cottee, Matthew A., Conduit, Paul T., Lea, Susan M., Raff, Jordan W.

“…In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold…”
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Centrosome Amplification Can Initiate Tumorigenesis in Flies by Basto, Renata, Brunk, Kathrin, Vinadogrova, Tatiana, Peel, Nina, Franz, Anna, Khodjakov, Alexey, Raff, Jordan W.

“…Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic…”
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A homeostatic clock sets daughter centriole size in flies by Aydogan, Mustafa G, Wainman, Alan, Saurya, Saroj, Steinacker, Thomas L, Caballe, Anna, Novak, Zsofia A, Baumbach, Janina, Muschalik, Nadine, Raff, Jordan W

“…Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4…”
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Asterless Licenses Daughter Centrioles to Duplicate for the First Time in Drosophila Embryos by Novak, Zsofia A., Conduit, Paul T., Wainman, Alan, Raff, Jordan W.

“…Centrioles form centrosomes and cilia, and defects in any of these three organelles are associated with human disease [1]. Centrioles duplicate once per cell…”
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Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly by Wong, Siu‐Shing, Wilmott, Zachary M, Saurya, Saroj, Alvarez‐Rodrigo, Ines, Zhou, Felix Y, Chau, Kwai‐Yin, Goriely, Alain, Raff, Jordan W

“…Mitotic centrosomes are formed when centrioles start to recruit large amounts of pericentriolar material (PCM) around themselves in preparation for mitosis…”
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CP110 exhibits novel regulatory activities during centriole assembly in Drosophila by Franz, Anna, Roque, Hélio, Saurya, Saroj, Dobbelaere, Jeroen, Raff, Jordan W

“…CP110 is a conserved centriole protein implicated in the regulation of cell division, centriole duplication, and centriole length and in the suppression of…”
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Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo by Baumbach, Janina, Novak, Zsofia Anna, Raff, Jordan W, Wainman, Alan

“…Acentriolar microtubule organizing centers (aMTOCs) are formed during meiosis and mitosis in several cell types, but their function and assembly mechanism is…”
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From Stem Cell to Embryo without Centrioles by Stevens, Naomi R., Raposo, Alexandre A.S.F., Basto, Renata, St Johnston, Daniel, Raff, Jordan W.

“…Centrosome asymmetry plays a key role in ensuring the asymmetric division of Drosophila neural stem cells (neuroblasts [NBs]) and male germline stem…”
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Drosophila Ana2 is a conserved centriole duplication factor by Stevens, Naomi R, Dobbelaere, Jeroen, Brunk, Kathrin, Franz, Anna, Raff, Jordan W

“…In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5…”
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Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation by Roque, Helio, Saurya, Saroj, Pratt, Metta B, Johnson, Errin, Raff, Jordan W

“…Pericentrin is a conserved centrosomal protein whose dysfunction has been linked to several human diseases. It has been implicated in many aspects of…”
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Overexpressing Centriole-Replication Proteins In Vivo Induces Centriole Overduplication and De Novo Formation by Peel, Nina, Stevens, Naomi R., Basto, Renata, Raff, Jordan W.

“…Centrosomes have important roles in many aspects of cell organization, and aberrations in their number and function are associated with various diseases,…”
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Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila Centrosomin by Lucas, Eliana P, Raff, Jordan W

“…Centrosomes consist of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centrioles and PCM are connected. We show…”
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Evidence that a positive feedback loop drives centrosome maturation in fly embryos by Alvarez-Rodrigo, Ines, Steinacker, Thomas L, Saurya, Saroj, Conduit, Paul T, Baumbach, Janina, Novak, Zsofia A, Aydogan, Mustafa G, Wainman, Alan, Raff, Jordan W

“…Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter…”
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