Characterization of SCCmec Types and Antibacterial Susceptibility Patterns of Methicillin-Resistant Staphylococcus aureus in Southern Iran

A total of 156 methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients hospitalized in southern Iran were tested for staphylococcal cassette chromosome mec (SCCmec) types and antibacterial susceptibility patterns between May 2008 and May 2009. Type III SCCmec was the most prevalent...

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Bibliographic Details
Published in:	Japanese Journal of Infectious Diseases Vol. 64; no. 1; pp. 28 - 33
Main Authors:	Japoni, Aziz, Jamalidoust, Marzieh, Farshad, Shohrah, Ziyaeyan, Mazyar, Alborzi, Abdolvahab, Japoni, Sara, Rafaatpour, Norradin
Format:	Journal Article
Language:	English
Published:	Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 01-01-2011
Subjects:	Anti-Bacterial Agents - pharmacology Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Cross Infection - epidemiology Cross Infection - microbiology Drug Resistance, Multiple, Bacterial - genetics Humans Iran - epidemiology Methicillin-Resistant Staphylococcus aureus - classification Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbial Sensitivity Tests Polymerase Chain Reaction - methods Prevalence Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcus aureus Iran
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Summary:	A total of 156 methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients hospitalized in southern Iran were tested for staphylococcal cassette chromosome mec (SCCmec) types and antibacterial susceptibility patterns between May 2008 and May 2009. Type III SCCmec was the most prevalent (116, 74.3%), followed by mec types A (147 bp only; 11, 7.1%), IVa (8, 5.1%), IVc (7, 4.5%), IVd and V (4, 2.6%), and II (1, 0.6%). Class A mec and type III ccr and mec complexes were also predominant. All isolates were found to be sensitive to vancomycin, teicoplanin, linezolid, quinupristin-dalfopristin, mupirocin, and fusidic acid. However, reduced sensitivity of these MRSA isolates to other antibiotics, including rifampin, co-trimoxazole, clindamycin, cephalexin, tetracycline, ciprofloxacin, erythromycin, and gentamicin, was also observed. The predomination of type III SCCmec could be due to the antibiotic pressure which facilitated its clonal selection and dissemination. The present findings are indicative of the existence of community-acquired types (IV, V) in the hospitals studied, therefore comprehensive and periodic control measures and rational prescription of appropriate antibiotics are highly recommended to reduce antibiotic resistance.
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ISSN:	1344-6304 1884-2836
DOI:	10.7883/yoken.64.28