Search Results - "Raedler, Thomas"

Inflammatory mechanisms in major depressive disorder by Raedler, Thomas J

“…PURPOSE OF REVIEWAs the ‘monoamine hypothesis of depression’ fails to explain all aspects of major depression, additional causes are being investigated…”
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Guidelines for the Pharmacotherapy of Schizophrenia in Adults by Remington, Gary, Addington, Donald, Honer, William, Ismail, Zahinoor, Raedler, Thomas, Teehan, Michael

“…Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults across different stages, phases, and symptom domains. Method:…”
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Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers by Jahn, Holger, Wittke, Stefan, Zürbig, Petra, Raedler, Thomas J, Arlt, Sönke, Kellmann, Markus, Mullen, William, Eichenlaub, Martin, Mischak, Harald, Wiedemann, Klaus

“…Today, dementias are diagnosed late in the course of disease. Future treatments have to start earlier in the disease process to avoid disability requiring new…”
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Cardiovascular aspects of antipsychotics by Raedler, Thomas J

“…PURPOSE OF REVIEWSchizophrenia is associated with increased mortality and reduced life expectancy, with cardiovascular disease being the most frequent cause of…”
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Pathological gambling is linked to reduced activation of the mesolimbic reward system by Büchel, Christian, Reuter, Jan, Raedler, Thomas, Rose, Michael, Hand, Iver, Gläscher, Jan

“…By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward…”
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No Effects of Antidepressants on Negative Symptoms in Schizophrenia by HINKELMANN, Kim, YASSOURIDIS, Alexander, KELLNER, Michael, JAHN, Holger, WIEDEMANN, Klaus, RAEDLER, Thomas J

“…Negative symptoms are common in schizophrenia, but often difficult to differentiate from depression. They are associated with long-term impairment and do not…”
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Will lithium damage my kidneys? by Raedler, Thomas J., MD

“…So far, no tools exist to identify patients at risk for [Li]-induced nephro - pathies early.14 Serial measurements of serum creatinine have traditionally been…”
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Poster #243 THE BRAIN-GUT CONNECTION: CONSTIPATION IN SCHIZOPHRENIA by Sivapalan, Sudhakar, Raedler, Thomas J

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Comparison of the in-vivo muscarinic cholinergic receptor availability in patients treated with clozapine and olanzapine by Raedler, Thomas J.

“…Clozapine and olanzapine are two atypical antipsychotics that bind to a broad range of receptors in vitro. Our group previously reported on the binding of…”
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In Vivo Determination of Muscarinic Acetylcholine Receptor Availability in Schizophrenia by Raedler, Thomas J., Knable, Michael B., Jones, Douglas W., Urbina, Richard A., Gorey, Julia G., Lee, Kan S., Egan, Michael F., Coppola, Richard, Weinberger, Daniel R.

“…OBJECTIVE: Postmortem studies have implicated the central muscarinic acetylcholine system in schizophrenia. However, central muscarinic receptor availability…”
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CSF-studies in neuropsychiatric disorders by Raedler, Thomas J, Wiedemann, Klaus

“…Cerebrospinal fluid (CSF) is a clear and colourless fluid that surrounds the brain and spine. Due to the close proximity of CSF to the brain, pathological…”
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Early onset of treatment effects with oral risperidone by Raedler, Thomas J, Schreiner, Andreas, Naber, Dieter, Wiedemann, Klaus

“…The dogma of a delayed onset of antipsychotic treatment effects has been maintained over the past decades. However, recent studies have challenged this…”
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Variability of the in vivo metabolism of clozapine by Raedler, Thomas J, Hinkelmann, Kim, Wiedemann, Klaus

“…Clozapine, the gold standard of antipsychotic treatment in treatment-refractory patients with schizophrenia, is metabolized in vivo to clozapine-N-oxide and…”
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Capillary electrophoresis mass spectrometry as a potential tool to detect lithium-induced nephropathy: Preliminary results by Raedler, Thomas J., Wittke, Stefan, Jahn, Holger, Koessler, Andreas, Mischak, Harald, Wiedemann, Klaus

“…Lithium remains the treatment of choice for many patients suffering from bipolar disorder. However, long-term treatment with lithium carries the potential to…”
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Cognitive enhancing drugs for schizophrenia by Raedler, Thomas J

“…Schizophrenia is frequently associated with cognitive deficits that are already present at an early stage of illness. Cognitive deficits in schizophrenia cover…”
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Schizophrenia as a developmental disorder of the cerebral cortex by Raedler, Thomas J, Knable, Michael B, Weinberger, Daniel R

“…The hypothesis that schizophrenia results from a developmental, as opposed to a degenerative, process affecting the cerebral cortex has become popular in…”
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Dose-dependent constipation with higher doses of quetiapine: a case series by Raedler, Thomas J, Reimer, Jens, Wiedemann, Klaus

“…Quetiapine is a dopamine D2 and serotonin 5-HT2 antagonist with antipsychotic and mood-stabilizing properties. Recent studies suggest that higher doses of…”
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Central Muscarinic Acetylcholine Receptor Availability in Patients Treated with Clozapine by RAEDLER, Thomas J, KNABLE, Michael B, JONES, Douglas W, URBINA, Richard A, EGAN, Michael F, WEINBERGER, Daniel R

“…Clozapine is the prototypical atypical antipsychotic. In vitro, clozapine antagonizes a broad range of receptors, including dopamine, serotonin and muscarinic…”
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Long-Term Outcomes in Psychopathology Research: Rethinking the Scientific Agenda by Raedler, Thomas J.

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Canadian Treatment Guidelines for Individuals at Clinical High Risk of Psychosis by Addington, Jean, Addington, Donald, Abidi, Sabina, Raedler, Thomas, Remington, Gary

“…Objective: Young people who are at clinical high risk (CHR) of developing psychosis are often help seeking and have significant distress and dysfunction. There…”
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