Search Results - "Radzun, H. J."

Increased number of mature dendritic cells in Crohn’s disease: evidence for a chemokine mediated retention mechanism by Middel, P, Raddatz, D, Gunawan, B, Haller, F, Radzun, H-J

“…Background and aims: Activation of T cells by dendritic cells (DC) is thought to play a pivotal role in induction and maintenance of Crohn’s disease. Detailed…”
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Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK ERK activation by SCHWEYER, S, SORURI, A, MESCHTER, O, HEINTZE, A, ZSCHUNKE, F, MIOSGE, N, THELEN, P, SCHLOTT, T, RADZUN, H. J, FAYYAZI, A

“…Testicular germ cell tumours (TGCT) represent the most common malignancies in young males. Whereas in 1970s, the survival rate in patients with metastatic…”
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The role of beta-catenin mutation and SOX9 expression in sex cord-stromal tumours of the testis by Bremmer, F., Behnes, C. L., Schildhaus, H. U., Gaisa, N. T., Reis, H., Jarry, H., Radzun, H. J., Stroebel, P., Schweyer, S.

“…The WHO classification of testis tumours includes the group of sex cord-stromal tumours. They are divided into several histological types, i.e. Leydig cell…”
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Expression and Function of the Vitamin D Receptor in Malignant Germ Cell Tumour of the Testis by BREMMER, F, THELEN, P, POTTEK, T, BEHNES, C. L, RADZUN, H. J, SCHWEYER, S

“…Testicular germ cell tumours (TGCTs) are the most common malignancy in young men aged 18-35 years. They are clinically and histologically subdivided into…”
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The role of reactive oxygen species in cisplatin-induced apoptosis in human malignant testicular germ cell lines by Schweyer, S, Soruri, A, Heintze, A, Radzun, H J, Fayyazi, A

“…Testicular germ cell tumours (TGCT) are the most common solid tumour among young males. Whereas in 1970s, only 5% of patients with a metastatic testicular…”
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Expression and function of protein phosphatase PP2A in malignant testicular germ cell tumours by Schweyer, S, Bachem, A, Bremmer, F, Steinfelder, HJ, Soruri, A, Wagner, W, Pottek, T, Thelen, P, Hopker, WW, Radzun, HJ, Fayyazi, A

“…Testicular germ cell tumours (TGCT) represent the most common malignancy in young males. We reported previously that two prototype members of the…”
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Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma by Kugler, A, Hemmerlein, B, Thelen, P, Kallerhoff, M, Radzun, H J, Ringert, R H

“…Degradation of the extracellular matrix is necessary for invasion and metastasis by cancer cells. Two gelatinolytic matrix metalloproteinase enzymes, MMP-2 and…”
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Expression of VCAM-1, ICAM-1, E- and P-selectin and tumour-associated macrophages in renal cell carcinoma by Hemmerlein, B, Scherbening, J, Kugler, A, Radzun, H-J

“…Aims Neoangiogenesis is accompanied by an increase in endothelial surface, which can support infiltration by immune cells depending on adhesion molecule…”
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Switch of cadherin expression as a diagnostic tool for Leydig cell tumours by Bremmer, F, Schweyer, S, Martin-Ortega, M, Hemmerlein, B, Strauss, A, Radzun, HJ, Behnes, CL

“…Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis…”
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Sinus histiocytosis with massive lymphadenopathy: evidence for its relationship to macrophages and for a cytokine-related disorder by MIDDEL, P, HEMMERLEIN, B, FAYYAZI, A, KABOTH, U, RADZUN, H.-J

“…Aims Sinus histiocytosis with massive lymphadenopathy (SHML) or Rosai–Dorfman disease is a rare histiocytic disorder of unknown origin. Immunophenotypically…”
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Interleukin 16 expression and phenotype of interleukin 16 producing cells in Crohn's disease by Middel, P, Reich, K, Polzien, F, Blaschke, V, Hemmerlein, B, Herms, J, Korabiowska, M, Radzun, H-J

“…BACKGROUND The mechanisms involved in the initiation and maintenance of Crohn's disease are poorly understood. Previous studies have demonstrated an increased…”
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Continuous recruitment, co-expression of tumour necrosis factor-α and matrix metalloproteinases, and apoptosis of macrophages in gout tophi by SCHWEYER, S, HEMMERLEIN, B, RADZUN, H. J, FAYYAZI, A

“…Gout tophi are characterised by foreign body granulomas consisting of mono- and multinucleated macrophages surrounding deposits of monosodium urate…”
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Liver infiltrating T lymphocytes express interferon γ and inducible nitric oxide synthase in chronic hepatitis C virus infection by Schweyer, S, Mihm, S, Radzun, H J, Hartmann, H, Fayyazi, A

“…BACKGROUND Pathogenesis of hepatitis C virus (HCV) associated liver injury is thought to be due to the host antiviral immune response. Using a quantitative,…”
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Expression of IFNγ, coexpression of TNFα and matrix metalloproteinases and apoptosis of T lymphocytes and macrophages in granuloma annulare by FAYYAZI, A, SCHWEYER, S, EICHMEYER, B, HERMS, J, HEMMERLEIN, B, RADZUN, H. J, BERGER, H

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Apoptosis of macrophages and T cells in tuberculosis associated caseous necrosis by Fayyazi, Afshin, Eichmeyer, Birgit, Soruri, Afsaneh, Schweyer, Stefan, Herms, Jochen, Schwarz, Peter, Radzun, Heinz J.

“…Immunity against mycobacteria is almost exclusively confined to epithelioid cell granulomas, where a long‐lasting but labile balance exists between host and…”
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The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells by Fayyazi, A., Scheel, O., Werfel, T., Schweyer, S., Oppermann, M., Götze, O., Radzun, H. J., Zwirner, J.

“…Summary C5a, a 74 amino acid peptide cleaved from the complement protein C5, is an extremely potent anaphylatoxin. Expression of the receptor for the…”
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Expression of CXC chemokine IP-10 in testicular germ cell tumours by Schweyer, S., Soruri, A., Baumhoer, D., Peters, J., Cattaruzza, M., Radzun, H. J., Fayyazi, A.

“…Tumour‐infiltrating T lymphocytes (TILs) possess discrepant properties ranging from anti‐ to pro‐tumour activities. Understanding precisely which mechanisms…”
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T lymphocytes and altered keratinocytes express interferon-γ and interleukin 6 in lichen planus by FAYYAZI, A, SCHWEYER, S, SORURI, A, DUONG, L. Q, RADZUN, H. J, PETERS, J, PARWARESCH, R, BERGER, H

“…Lichen planus is assumed to represent a delayed hypersensitivity reaction, in the course of which cytokines control the proliferation and differentiation of…”
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QUANTIFICATION AND IN SITU LOCALIZATION OF MCP-1 mRNA AND ITS RELATION TO THE IMMUNE RESPONSE OF RENAL CELL CARCINOMA by Hemmerlein, B., Johanns, U., Kugler, A., Reffelmann, M., Radzun, H.-J.

“…Malignant tumours are usually accompanied by an immune response. Chemokines such as MCP-1 have been claimed to be potent inducers of such tumour-associated…”
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Malignant germ cell tumours of the testis express interferon-gamma, but are resistant to endogenous interferon-gamma by Schweyer, S, Soruri, A, Peters, J, Wagner, A, Radzun, H J, Fayyazi, A

“…Cytokines possess discrepant effects on tumour cells varying from anti- to proapoptotic activities. We recently reported that testicular germ cell tumours…”
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