Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities

Synthesis of new derivatives of hydrazinecarbothioamides and 1,2,4-triazoles and evaluation of their antimicrobial activities

A new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of 10-13 with...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society Vol. 80; no. 12; pp. 1461 - 1470
Main Authors: Socea Laura I., Saramet Gabriel, Draghici Constantin, Socea Bogdan, Constantin Vlad D., Radu-Popescu Manuela A.
Format: Journal Article
Language:English
Published: Serbian Chemical Society 01-01-2015
Subjects:
1,2,4-triazol-3-thiole
acylhydrazinecarbothioamide
antimicrobial activity
dibenzo[a,d]annulene
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Summary:A new series of hydrazinecarbothioamides 6-9 bearing 5H-dibenzo[a,d][7]annulene moiety were synthesized. Cyclization of 6-9 in NaOH solution produced the corresponding 1,2,4-triazoles-3(4H)-thiol 10-13, which proved to be axial isomers. The thioethers 14-17 were prepared by alkylation of 10-13 with methyl iodide. All new compounds were characterized by elemental analysis, IR-, UV-, 1H-NMR and 13C-NMR spectroscopy. The evaluation for antimicrobial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 6663, Salmonella tiphimurium ATCC 14028, Shigella flexneri ATCC 12022, Candida albicans ATCC 90028 was performed.
ISSN:0352-5139
1820-7421
DOI:10.2298/JSC150227039S