Search Results - "Radu A. POPP"

Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia by Cabău, Georgiana, Crișan, Tania O., Klück, Viola, Popp, Radu A., Joosten, Leo A. B.

“…Trained immunity is a process in which innate immune cells undergo functional reprogramming in response to pathogens or damage‐associated molecules leading to…”
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Enhanced Innate and Acquired Immune Responses in Systemic Sclerosis Primary Peripheral Blood Mononuclear Cells (PBMCs) by Szabo, Iulia, Badii, Medeea, Gaál, Ildikó O., Szabo, Robert, Popp, Radu A., Joosten, Leo A. B., Crişan, Tania O., Rednic, Simona

“…Chronic immune activation in systemic sclerosis is supported by the production of a plethora of cytokines with proven regulatory activities of the immune…”
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GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells by Gaal, Orsolya I., Liu, Ruiqi, Marginean, Dragoș, Badii, Medeea, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Colcear, Doina, Pamfil, Cristina, Merriman, Tony R., Rednic, Simona, Popp, Radu A., Crișan, Tania O., Joosten, Leo A. B.

“…Gout is a common autoinflammatory joint diseases characterized by deposition of monosodium urate (MSU) crystals which trigger an innate immune response…”
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MECOM, HBS1L‐MYB, THRB‐RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients by Trifa, Adrian P., Bănescu, Claudia, Bojan, Anca S., Voina, Cristian M., Popa, Ștefana, Vișan, Simona, Ciubean, Alina D., Tripon, Florin, Dima, Delia, Popov, Viola M., Vesa, Ștefan C., Andreescu, Mihaela, Török‐Vistai, Tünde, Mihăilă, Romeo G., Berbec, Nicoleta, Macarie, Ioan, Coliţă, Andrei, Iordache, Maria, Cătană, Alina C., Farcaș, Marius F., Tomuleasa, Ciprian, Vasile, Kinga, Truică, Cristina, Todincă, Adriana, Pop‐Muntean, Lavinia, Manolache, Raluca, Bumbea, Horia, Vlădăreanu, Ana‐Maria, Gaman, Mihaela, Ciufu, Cristina M., Popp, Radu A.

“…Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are classical myeloproliferative neoplasms (MPN), characterized by…”
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TERT rs2736100 A>C SNP and JAK2 46/1 haplotype significantly contribute to the occurrence of JAK2 V617F and CALR mutated myeloproliferative neoplasms – a multicentric study on 529 patients by Trifa, Adrian P., Bănescu, Claudia, Tevet, Mihaela, Bojan, Anca, Dima, Delia, Urian, Laura, Török‐Vistai, Tünde, Popov, Viola M., Zdrenghea, Mihnea, Petrov, Ljubomir, Vasilache, Anca, Murat, Meilin, Georgescu, Daniela, Popescu, Mihaela, Pătrinoiu, Oana, Balea, Marius, Costache, Roxana, Coleș, Elena, Șaguna, Carmen, Berbec, Nicoleta, Vlădăreanu, Ana‐Maria, Mihăilă, Romeo G., Bumbea, Horia, Cucuianu, Andrei, Popp, Radu A.

“…Polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) represent typical myeloproliferative neoplasms (MPN), usually…”
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Hyperuricemia remodels the serum proteome toward a higher inflammatory state by Cabău, Georgiana, Gaal, Orsolya, Badii, Medeea, Nica, Valentin, Mirea, Andreea-Manuela, Hotea, Ioana, Pamfil, Cristina, Popp, Radu A., Netea, Mihai G., Rednic, Simona, Crișan, Tania O., Joosten, Leo A.B.

“…Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an…”
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Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA Vaccination by Cabău, Georgiana, Badii, Medeea, Mirea, Andreea M, Gaal, Orsolya I, van Emst, Liesbeth, Popp, Radu A, Crișan, Tania O, Joosten, Leo A B

“…The mRNA vaccine against COVID-19 protects against severe disease by the induction of robust humoral and cellular responses. Recent studies have shown the…”
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Trained immunity and inflammation in rheumatic diseases by Badii, Medeea, Gaal, Orsolya, Popp, Radu A., Crișan, Tania O., Joosten, Leo A.B.

“…•Innate immune cells can mount an immunological memory called trained immunity.•Long-term innate immune adaptations occur via epigenetic and metabolic…”
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CALR versus JAK2 mutated essential thrombocythaemia - a report on 141 patients by Trifa, Adrian P, Popp, Radu A, Cucuianu, Andrei, Bănescu, Claudia, Tevet, Mihaela, Martin, Bianca, Murat, Meilin, Vesa, Stefan C, Dima, Delia, Cândea, Marcela, Militaru, Mariela S, Pop, Ioan V

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Downregulation of type I interferon signalling pathway by urate in primary human PBMCs by Badii, Medeea, Nica, Valentin, Straton, Ancuța R, Kischkel, Brenda, Gaal, Orsolya, Cabău, Georgiana, Klück, Viola, Hotea, Ioana, Novakovic, Boris, Pamfil, Cristina, Rednic, Simona, Netea, Mihai G, Popp, Radu A, Joosten, Leo A B, Crișan, Tania O

“…Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagonist (Ra) production in human…”
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The future clinical implications of trained immunity by Nica, Valentin, Popp, Radu A, Crișan, Tania O, Joosten, Leo A B

“…Trained Immunity (TI) refers to the long-term modulation of the innate immune response, based on previous interactions with microbes, microbial ligands, or…”
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Familial Essential Thrombocythemia Associated with MPL W515L Mutation in Father and JAK2 V617F Mutation in Daughter by Trifa, Adrian P., Popp, Radu A., Cucuianu, Andrei

“…Familial essential thrombocythemia features the acquisition of somatic mutations and an evolution similar to the sporadic form of the disease. Here we report…”
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Regulation of SOCS3-STAT3 in urate-induced cytokine production in human myeloid cells by Badii, Medeea, Klück, Viola, Gaal, Orsolya, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Mirea, Andreea M., Bojan, Anca, Zdrenghea, Mihnea, Novakovic, Boris, Merriman, Tony R., Liu, Zhaoli, Li, Yang, Xu, Cheng-Jian, Pamfil, Cristina, Rednic, Simona, Popp, Radu A., Crişan, Tania O., Joosten, Leo A.B.

“…•Urate-primed PBMCs of hyperuricemic and gout patients show dysregulated cytokine production.•SOCS3 is enhanced in urate-primed myeloid cells, and this is…”
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Modest contribution of JAK2 V617F allele burden to the occurrence of major thrombosis in polycthemia vera and essential thrombocythemia by Trifa, Adrian P., Bănescu, Claudia, Voina, Cristian M., Popa, Ștefana, Török-Vistai, Tünde, Bojan, Anca S., Dima, Delia, Zdrenghea, Mihnea, Fetica, Bogdan, Vișan, Simona, Tomuleasa, Ciprian, Pârvu, Andrada, Urian, Laura, Pop, Bogdan, Popov, Viola M., Andreescu, Mihaela, Popp, Radu A.

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Cholelithiasis in Patients with Gaucher Disease type 1: Risk Factors and the Role of ABCG5/ABCG8 Gene Variants by Zimmermann, Anca, Popp, Radu A, Al-Khzouz, Camelia, Bucerzan, Simona, Naşcu, Ioana, Leucuta, Daniel, Galle, Peter R., Grigorescu-Sido, Paula

“…Background & Aim: Patients with Gaucher disease type 1 (GD1) show an altered lipid profile and a certain degree of insulin resistance, which might contribute…”
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The C677T Variant in the Methylenetetrahydrofolate Reductase Gene and Idiopathic Spontaneous Abortion in a Romanian Population Group by POPP, Radu A., CRISAN, Tania O., TRIFA, Adrian P., MILITARU, Mariela S., ROTAR, Ioana C., FARCAS, Marius F., POP, Ioan V.

“…Spontaneous abortions (SA) are a major public health problem and a frequent pregnancy associated disorder. Hereditary thrombophilia and hyperhomocysteinemia…”
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The glucocorticoid receptor A3669G SNP is not associated with polycythemia vera, essential thrombocythemia or primary myelofibrosis by Costache, Roxana M., Bănescu, Claudia, Popp, Radu A., Pop, Ioan V., Trifa, Adrian P.

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TET2 rs1548483 SNP Associating with Susceptibility to Molecularly Annotated Polycythemia Vera and Primary Myelofibrosis by Lighezan, Diana L., Bojan, Anca S., Iancu, Mihaela, Pop, Raluca M., Gligor-Popa, Ștefana, Tripon, Florin, Cosma, Adriana S., Tomuleasa, Ciprian, Dima, Delia, Zdrenghea, Mihnea, Fetica, Bogdan, Ioniță, Ioana, Gaál, Ildikó O., Vișan, Simona, Mirea, Andreea-Manuela, Popp, Radu A., Florea, Mira, Araniciu, Cătălin, Petrescu, Lucian, Pop, Ioan V., Bănescu, Claudia, Trifa, Adrian P.

“…Background: The complexity of myeloproliferative neoplasms (MPNs) cannot be characterized by acquired somatic mutations alone. Individual genetic background is…”
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Gene variants of osteoprotegerin, estrogen-, calcitonin- and vitamin D-receptor genes and serum markers of bone metabolism in patients with Gaucher disease type 1 by Zimmermann, Anca, Popp, Radu A, Rossmann, Heidi, Bucerzan, Simona, Nascu, Ioana, Leucuta, Daniel, Weber, Matthias M, Grigorescu-Sido, Paula

“…Osteopathy/osteoporosis in Gaucher disease type 1 (GD1) shows variable responses to enzyme replacement therapy (ERT); the pathogenesis is incompletely…”
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Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms by Trifa, Adrian P, Bănescu, Claudia, Dima, Delia, Bojan, Anca S, Tevet, Mihaela, Moldovan, Valeriu G, Vesa, Ștefan C, Murat, Meilin, Pop, Ioan V, Skrypnyk, Cristina, Popp, Radu A

“…To analyze the relationship between six polymorphisms in genes related to oxidative stress, namely CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu, GSTM1 and GSTT1…”
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