Search Results - "Radu, Tudor B"

PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia by Gawel, Justyna M., Shouksmith, Andrew E., Raouf, Yasir S., Nawar, Nabanita, Toutah, Krimo, Bukhari, Shazreh, Manaswiyoungkul, Pimyupa, Olaoye, Olasunkanmi O., Israelian, Johan, Radu, Tudor B., Cabral, Aaron D., Sina, Diana, Sedighi, Abootaleb, de Araujo, Elvin D., Gunning, Patrick T.

“…Dysregulated Histone Deacetylase (HDAC) activity across multiple human pathologies have highlighted this family of epigenetic enzymes as critical druggable…”
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Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T‑Cell Prolymphocytic Leukemia by Toutah, Krimo, Nawar, Nabanita, Timonen, Sanna, Sorger, Helena, Raouf, Yasir S, Bukhari, Shazreh, von Jan, Jana, Ianevski, Aleksandr, Gawel, Justyna M, Olaoye, Olasunkanmi O, Geletu, Mulu, Abdeldayem, Ayah, Israelian, Johan, Radu, Tudor B, Sedighi, Abootaleb, Bhatti, Muzaffar N, Hassan, Muhammad Murtaza, Manaswiyoungkul, Pimyupa, Shouksmith, Andrew E, Neubauer, Heidi A, de Araujo, Elvin D, Aittokallio, Tero, Krämer, Oliver H, Moriggl, Richard, Mustjoki, Satu, Herling, Marco, Gunning, Patrick T

“…Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known…”
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Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma by Nawar, Nabanita, Bukhari, Shazreh, Adile, Ashley A, Suk, Yujin, Manaswiyoungkul, Pimyupa, Toutah, Krimo, Olaoye, Olasunkanmi O, Raouf, Yasir S, Sedighi, Abootaleb, Garcha, Harsimran Kaur, Hassan, Muhammad Murtaza, Gwynne, William, Israelian, Johan, Radu, Tudor B, Geletu, Mulu, Abdeldayem, Ayah, Gawel, Justyna M, Cabral, Aaron D, Venugopal, Chitra, de Araujo, Elvin D, Singh, Sheila K, Gunning, Patrick T

“…Histone deacetylase 6 (HDAC6) has been targeted in clinical studies for anticancer effects due to its role in oncogenic transformation and metastasis. Through…”
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Structural and mutational analysis of member-specific STAT functions by Erdogan, Fettah, Qadree, Abdul K., Radu, Tudor B., Orlova, Anna, de Araujo, Elvin D., Israelian, Johan, Valent, Peter, Mustjoki, Satu M., Herling, Marco, Moriggl, Richard, Gunning, Patrick T.

“…The STAT family of transcription factors control gene expression in response to signals from various stimulus. They display functions in diseases ranging from…”
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Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype by Olaoye, Olasunkanmi O, Watson, Paris R, Nawar, Nabanita, Geletu, Mulu, Sedighi, Abootaleb, Bukhari, Shazreh, Raouf, Yasir S, Manaswiyoungkul, Pimyupa, Erdogan, Fettah, Abdeldayem, Ayah, Cabral, Aaron D, Hassan, Muhammad Murtaza, Toutah, Krimo, Shouksmith, Andrew E, Gawel, Justyna M, Israelian, Johan, Radu, Tudor B, Kachhiyapatel, Niyati, de Araujo, Elvin D, Christianson, David W, Gunning, Patrick T

“…Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant…”
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Optical chemosensors for the detection of proximally phosphorylated peptides and proteins by Cabral, Aaron D, Radu, Tudor B, de Araujo, Elvin D, Gunning, Patrick T

“…Proximal multi-site phosphorylation is a critical post-translational modification in protein biology. The additive effects of multiple phosphosite clusters in…”
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Sensitive Detection of Broad-Spectrum Bacteria with Small-Molecule Fluorescent Excimer Chemosensors by Cabral, Aaron D, Rafiei, Nafiseh, de Araujo, Elvin D, Radu, Tudor B, Toutah, Krimo, Nino, Daniel, Murcar-Evans, Bronte I, Milstein, Joshua N, Kraskouskaya, Dziyana, Gunning, Patrick T

“…Antibiotic resistance is a major problem for world health, triggered by the unnecessary usage of broad-spectrum antibiotics on purportedly infected patients…”
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Structural and utational nalysis of ember-pecific STAT unctions by Erdogan, Fettah, Qadree, Abdul K., Radu, Tudor B., Orlova, Anna, de Araujo, Elvin D., Israelian, Johan, Valent, Peter, Mustjoki, Satu M., Herling, Marco, Moriggl, Richard, Gunning, Patrick T.

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