Search Results - "Radstake, Timothy"

EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors by Kostine, Marie, Finckh, Axel, Bingham, Clifton O, Visser, Karen, Leipe, Jan, Schulze-Koops, Hendrik, Choy, Ernest H, Benesova, Karolina, Radstake, Timothy R D J, Cope, Andrew P, Lambotte, Olivier, Gottenberg, Jacques-Eric, Allenbach, Yves, Visser, Marianne, Rusthoven, Cindy, Thomasen, Lone, Jamal, Shahin, Marabelle, Aurélien, Larkin, James, Haanen, John B A G, Calabrese, Leonard H, Mariette, Xavier, Schaeverbeke, Thierry

“…Rheumatic and musculoskeletal immune-related adverse events (irAEs) are observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs)…”
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Machine learning in rheumatology approaches the clinic by Pandit, Aridaman, Radstake, Timothy R. D. J.

“…Machine learning and high-throughput technologies hold promise for the classification, diagnosis and treatment of patients with rheumatic diseases, with the…”
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Multiomics and Machine Learning Accurately Predict Clinical Response to Adalimumab and Etanercept Therapy in Patients With Rheumatoid Arthritis by Tao, Weiyang, Concepcion, Arno N., Vianen, Marieke, Marijnissen, Anne C. A., Lafeber, Floris P. G. J., Radstake, Timothy R. D. J., Pandit, Aridaman

“…Objective To predict response to anti–tumor necrosis factor (anti‐TNF) prior to treatment in patients with rheumatoid arthritis (RA), and to comprehensively…”
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Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes by Tsuchida, Anika I, Beekhuizen, Michiel, 't Hart, Marieke C, Radstake, Timothy R D J, Dhert, Wouter J A, Saris, Daniel B F, van Osch, Gerjo J V M, Creemers, Laura B

“…This study aimed to evaluate whether profiles of several soluble mediators in synovial fluid and cartilage tissue are pathology-dependent and how their…”
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Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us? by van der Vlist, Michiel, Kuball, Jurgen, Radstake, Timothy R. D., Meyaard, Linde

“…Key Points Inhibitory immune checkpoint receptors are essential for immunological homeostasis, and their function and/or expression is often disturbed in…”
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New insights into the genetics and epigenetics of systemic sclerosis by Angiolilli, Chiara, Marut, Wioleta, van der Kroef, Maarten, Chouri, Eleni, Reedquist, Kris A., Radstake, Timothy R. D. J.

“…Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular abnormalities, immunological alterations and fibrosis of the skin and…”
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EULAR points to consider for the use of big data in rheumatic and musculoskeletal diseases by Gossec, Laure, Kedra, Joanna, Servy, Hervé, Pandit, Aridaman, Stones, Simon, Berenbaum, Francis, Finckh, Axel, Baraliakos, Xenofon, Stamm, Tanja A, Gomez-Cabrero, David, Pristipino, Christian, Choquet, Remy, Burmester, Gerd R, Radstake, Timothy R D J

“…Tremendous opportunities for health research have been unlocked by the recent expansion of big data and artificial intelligence. However, this is an emergent…”
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Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder by Boks, Marco P, Mierlo, Hans C. van, Rutten, Bart P.F, Radstake, Timothy R.D.J, De Witte, Lot, Geuze, Elbert, Horvath, Steve, Schalkwyk, Leonard C, Vinkers, Christiaan H, Broen, Jasper C.A, Vermetten, Eric

“…Summary Several studies have reported an association between traumatic stress and telomere length suggesting that traumatic stress has an impact on ageing at…”
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Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis by Garcia, Samuel, Hartkamp, Linda M, Malvar-Fernandez, B, van Es, Inge E, Lin, Haishan, Wong, Justin, Long, Li, Zanghi, James A, Rankin, Andrew L, Masteller, Emma L, Wong, Brian R, Radstake, Timothy R D J, Tak, Paul P, Reedquist, Kris A

“…CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is…”
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The role of genetics and epigenetics in the pathogenesis of systemic sclerosis by Broen, Jasper C. A., Radstake, Timothy R. D. J., Rossato, Marzia

“…Key Points Systemic sclerosis (SSc) is a complex autoimmune disease, the pathogenesis of which is influenced by genetic, epigenetic and environmental factors…”
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Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment by Affandi, Alsya J., Radstake, Timothy R. D. J., Marut, Wioleta

“…Systemic sclerosis (SSc) is a complex autoimmune disease in which immune activation, vasculopathy, and extensive fibrosis of the skin and internal organs are…”
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Perception of self: distinguishing autoimmunity from autoinflammation by van Kempen, Tessa S., Wenink, Mark H., Leijten, Emmerik F. A., Radstake, Timothy R. D. J., Boes, Marianne

“…Key Points Autoimmunity and autoinflammatory disorders are distinct in terms of the predominance of underlying innate or adaptive immune mechanisms,…”
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The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis by Cossu, Marta, van Bon, Lenny, Nierkens, Stefan, Bellocchi, Chiara, Santaniello, Alessandro, Dolstra, Harry, Beretta, Lorenzo, Radstake, Timothy R.D.J

“…Abstract Immune activation is a hallmark of systemic sclerosis (SSc). However, the immunological alterations that occur in preclinical and non-fibrotic SSc and…”
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Morphea and Eosinophilic Fasciitis: An Update by Mertens, Jorre S., Seyger, Marieke M. B., Thurlings, Rogier M., Radstake, Timothy R. D. J., de Jong, Elke M. G. J.

“…Morphea, also known as localized scleroderma, encompasses a group of idiopathic sclerotic skin diseases. The spectrum ranges from relatively mild phenotypes,…”
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Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis by Abdollahi-Roodsaz, Shahla, Joosten, Leo A B, Koenders, Marije I, Devesa, Isabel, Roelofs, Mieke F, Radstake, Timothy R D J, Heuvelmans-Jacobs, Marleen, Akira, Shizuo, Nicklin, Martin J H, Ribeiro-Dias, Fátima, van den Berg, Wim B

“…TLRs may contribute to the progression of rheumatoid arthritis through recognition of microbial or host-derived ligands found in arthritic joints. Here, we…”
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Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome by van der Linden, Maarten, van den Hoogen, Lucas L, Westerlaken, Geertje H A, Fritsch-Stork, Ruth D E, van Roon, Joël A G, Radstake, Timothy R D J, Meyaard, Linde

“…Abstract Objectives Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular…”
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Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation by Angiolilli, Chiara, Kabala, Pawel A, Grabiec, Aleksander M, Rossato, Marzia, Lai, Wi S, Fossati, Gianluca, Mascagni, Paolo, Steinkühler, Christian, Blackshear, Perry J, Reedquist, Kris A, Baeten, Dominique L, Radstake, Timothy R D J

“…Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we…”
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The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis by Mariotti, Barbara, Servaas, Nila Hendrika, Rossato, Marzia, Tamassia, Nicola, Cassatella, Marco A, Cossu, Marta, Beretta, Lorenzo, van der Kroef, Maarten, Radstake, Timothy R D J, Bazzoni, Flavia

“…TLR4 activation initiates a signaling cascade leading to the production of type I IFNs and of the downstream IFN-stimulated genes (ISGs). Recently, a number of…”
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Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells by Dutertre, Charles-Antoine, Becht, Etienne, Irac, Sergio Erdal, Khalilnezhad, Ahad, Narang, Vipin, Khalilnezhad, Shabnam, Ng, Pei Y., van den Hoogen, Lucas L., Leong, Jing Yao, Lee, Bernett, Chevrier, Marion, Zhang, Xiao Meng, Yong, Pearly Jean Ai, Koh, Geraldine, Lum, Josephine, Howland, Shanshan Wu, Mok, Esther, Chen, Jinmiao, Larbi, Anis, Tan, Henry Kun Kiaang, Lim, Tony Kiat Hon, Karagianni, Panagiota, Tzioufas, Athanasios G., Malleret, Benoit, Brody, Joshua, Albani, Salvatore, van Roon, Joel, Radstake, Timothy, Newell, Evan W., Ginhoux, Florent

“…Human mononuclear phagocytes comprise phenotypically and functionally overlapping subsets of dendritic cells (DCs) and monocytes, but the extent of their…”
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CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells by Silva-Cardoso, Sandra C, Affandi, Alsya J, Spel, Lotte, Cossu, Marta, van Roon, Joel A G, Boes, Marianne, Radstake, Timothy R D J

“…Chemokines have been shown to play immune-modulatory functions unrelated to steering cell migration. CXCL4 is a chemokine abundantly produced by activated…”
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