Search Results - "Radsak, Markus P"

Current Progress in Particle-Based Systems for Transdermal Vaccine Delivery by Pielenhofer, Jonas, Sohl, Julian, Windbergs, Maike, Langguth, Peter, Radsak, Markus P

“…Transcutaneous immunization (TCI) via needle-free and non-invasive drug delivery systems is a promising approach for overcoming the current limitations of…”
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Efficacy of imiquimod-based transcutaneous immunization using a nano-dispersed emulsion gel formulation by Stein, Pamela, Gogoll, Karsten, Tenzer, Stefan, Schild, Hansjörg, Stevanovic, Stefan, Langguth, Peter, Radsak, Markus P

“…Transcutaneous immunization (TCI) approaches utilize skin associated lymphatic tissues to elicit specific immune responses. In this context, the…”
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TREM-1 ligand expression on platelets enhances neutrophil activation by Haselmayer, Philipp, Grosse-Hovest, Ludger, von Landenberg, Philipp, Schild, Hansjörg, Radsak, Markus P.

“…The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis…”
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Pharmacological degradation of ATR induces antiproliferative DNA replication stress in leukemic cells by Kansy, Anita G., Ashry, Ramy, Mustafa, Al‐Hassan M., Alfayomy, Abdallah M., Radsak, Markus P., Zeyn, Yanira, Bros, Matthias, Sippl, Wolfgang, Krämer, Oliver H.

“…Mammalian cells replicate ~ 3 × 109 base pairs per cell cycle. One of the key molecules that slows down the cell cycle and prevents excessive DNA damage upon…”
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ERK3/MAPK6 controls IL-8 production and chemotaxis by Bogucka, Katarzyna, Pompaiah, Malvika, Marini, Federico, Binder, Harald, Harms, Gregory, Kaulich, Manuel, Klein, Matthias, Michel, Christian, Radsak, Markus P, Rosigkeit, Sebastian, Grimminger, Peter, Schild, Hansjörg, Rajalingam, Krishnaraj

“…ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life…”
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The Bruton tyrosine kinase inhibitor ibrutinib abrogates triggering receptor on myeloid cells 1-mediated neutrophil activation by Stadler, Nicole, Hasibeder, Astrid, Lopez, Pamela Aranda, Teschner, Daniel, Desuki, Alexander, Kriege, Oliver, Weber, Alexander N R, Schulz, Christoph, Michel, Christian, Heβ, Georg, Radsak, Markus P

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Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA by Siewert, Christian D., Haas, Heinrich, Cornet, Vera, Nogueira, Sara S., Nawroth, Thomas, Uebbing, Lukas, Ziller, Antje, Al-Gousous, Jozef, Radulescu, Aurel, Schroer, Martin A., Blanchet, Clement E., Svergun, Dmitri I., Radsak, Markus P., Sahin, Ugur, Langguth, Peter

“…Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different…”
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Optimized dithranol-imiquimod-based transcutaneous immunization enables tumor rejection by Hartmann, Ann-Kathrin, Bartneck, Joschka, Pielenhofer, Jonas, Meiser, Sophie Luise, Arnold-Schild, Danielle, Klein, Matthias, Stassen, Michael, Schild, Hansjörg, Muth, Sabine, Probst, Hans Christian, Langguth, Peter, Grabbe, Stephan, Radsak, Markus P.

“…Introduction Transcutaneous immunization (TCI) is a non-invasive vaccination method promoting strong cellular immune responses, crucial for the immunological…”
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Quality by Design (QbD) Approach for a Nanoparticulate Imiquimod Formulation as an Investigational Medicinal Product by Pielenhofer, Jonas, Meiser, Sophie Luise, Gogoll, Karsten, Ciciliani, Anna-Maria, Denny, Mark, Klak, Michael, Lang, Berenice M, Staubach, Petra, Grabbe, Stephan, Schild, Hansjörg, Radsak, Markus P, Spahn-Langguth, Hilde, Langguth, Peter

“…The present article exemplifies the application of the concept of quality by design (QbD) for the systematic development of a nanoparticulate imiquimod (IMQ)…”
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Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling by Bugl, Stefanie, Wirths, Stefan, Radsak, Markus P., Schild, Hansjörg, Stein, Pamela, André, Maya C., Müller, Martin R., Malenke, Elke, Wiesner, Tina, Märklin, Melanie, Frick, Julia-Stefanie, Handgretinger, Rupert, Rammensee, Hans-Georg, Kanz, Lothar, Kopp, Hans-Georg

“…Polymorphonuclear neutrophil granulocytes (neutrophils) are tightly controlled by an incompletely understood homeostatic feedback loop adjusting the marrow's…”
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Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo by Warger, Tobias, Osterloh, Philipp, Rechtsteiner, Gerd, Fassbender, Melanie, Heib, Valeska, Schmid, Beate, Schmitt, Edgar, Schild, Hansjörg, Radsak, Markus P.

“…Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their signals induce the coordinated activation of innate and adaptive…”
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Transcutaneous immunization with a novel imiquimod nanoemulsion induces superior T cell responses and virus protection by Lopez, Pamela Aranda, Denny, Mark, Hartmann, Ann-Kathrin, Alflen, Astrid, Probst, Hans Christian, von Stebut, Esther, Tenzer, Stefan, Schild, Hansjörg, Stassen, Michael, Langguth, Peter, Radsak, Markus P

“…Highlights • Transcutaneous immunization with the imiquimod formulation IMI-Sol induces superior responses in CD8 and CD 4 positive T-cells. • T-cell…”
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A role for Toll-like receptor mediated signals in neutrophils in the pathogenesis of the anti-phospholipid syndrome by Gladigau, Gerd, Haselmayer, Philipp, Scharrer, Inge, Munder, Markus, Prinz, Nadine, Lackner, Karl, Schild, Hansjörg, Stein, Pamela, Radsak, Markus P

“…The anti-phospholipid syndrome (APS) is characterized by recurrent thrombosis and occurrence of anti-phospholipid antibodies (aPL). aPL are necessary, but not…”
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Combined immunotherapy: CTLA-4 blockade potentiates anti-tumor response induced by transcutaneous immunization by Rausch, Johanna, Lopez, Pamela Aranda, Bialojan, Ariane, Denny, Mark, Langguth, Peter, Probst, Hans Christian, Schild, Hansjörg, Radsak, Markus P.

“…•Check point blockade of CTLA-4 augments TCI mediated T-cell responses and supports memory formation.•Combined immunotherapy with TCI and CTLA-4 blockade…”
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Author Correction: ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis by Alflen, Astrid, Prüfer, Steve, Ebner, Katharina, Reuter, Sebastian, Lopez, Pamela Aranda, Scharrer, Inge, Banno, Fumiaki, Stassen, Michael, Schild, Hansjörg, Jurk, Kerstin, Bosmann, Markus, Beckert, Hendrik, Radsak, Markus P.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis by Alflen, Astrid, Prüfer, Steve, Ebner, Katharina, Reuter, Sebastian, Aranda Lopez, Pamela, Scharrer, Inge, Banno, Fumiaki, Stassen, Michael, Schild, Hansjörg, Jurk, Kerstin, Bosmann, Markus, Beckert, Hendrik, Radsak, Markus P.

“…Von Willebrand factor (VWF) is secreted as an acute phase protein during inflammation. ADAMTS-13 regulates the size and prothrombotic activity of VWF by it’s…”
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Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival by Radsak, Markus P, Salih, Helmut R, Rammensee, Hans-Georg, Schild, Hansjorg

“…Polymorphonuclear neutrophils (PMN) are crucial in the innate host defense by their ability to rapidly accumulate in inflamed tissues and clear a site of…”
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Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2 -Mutant Mice by Gerardo-Ramírez, Monserrat, Giam, Vanessa, Becker, Diana, Groth, Marco, Hartmann, Nils, Morrison, Helen, May-Simera, Helen L, Radsak, Markus P, Marquardt, Jens U, Galle, Peter R, Herrlich, Peter, Straub, Beate K, Hartmann, Monika

“…Primary liver cancer is the third leading cause of cancer-related death worldwide. An increasing body of evidence suggests that the Hippo tumor suppressor…”
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Genetic variation determines mast cell functions in experimental asthma by Becker, Marc, Reuter, Sebastian, Friedrich, Pamela, Doener, Fatma, Michel, Anastasija, Bopp, Tobias, Klein, Matthias, Schmitt, Edgar, Schild, Hansjörg, Radsak, Markus P, Echtenacher, Bernd, Taube, Christian, Stassen, Michael

“…Mast cell-deficient mice are a key for investigating the function of mast cells in health and disease. Allergic airway disease induced as a Th2-type immune…”
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Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses by Warger, Tobias, Hilf, Nobert, Rechtsteiner, Gerd, Haselmayer, Philipp, Carrick, Deanna M., Jonuleit, Helmut, von Landenberg, Philipp, Rammensee, Hans-Georg, Nicchitta, Christopher V., Radsak, Markus P., Schild, Hansjörg

“…Activation of dendritic cells by ligands for Toll-like receptors (TLR) is a crucial event in the initiation of innate and adaptive immune responses. Several…”
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