Search Results - "Radominska, A"

Regulation of UDP glucuronosyltransferase genes by Mackenzie, P I, Gregory, P A, Gardner-Stephen, D A, Lewinsky, R H, Jorgensen, B R, Nishiyama, T, Xie, Wen, Radominska-Pandya, A

“…The UDP glucuronosyltransferase (UGT) content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by…”
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Human UDP-glucuronosyltransferase 2B7 by Radominska-Pandya, A, Little, J M, Czernik, P J

“…UDP-Glucuronosyltransferases (UGTs) are glycoproteins, localized in endoplasmic reticulum (ER) and nuclear membranes, which catalyze the confugation of a broad…”
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Human liver steroid sulphotransferase sulphates bile acids by RADOMINSKA, A, COMER, K. A, ZIMNIAK, P, FALANY, J, ISCAN, M, FALANY, C. N

“…The sulphation of bile acids is an important pathway for the detoxification and elimination of bile acids during cholestatic liver disease. A…”
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Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4 by Pillot, T, Ouzzine, M, Fournel-Gigleux, S, Lafaurie, C, Radominska, A, Burchell, B, Siest, G, Magdalou, J

“…Monospecific polyclonal antibodies were raised against a variable amino-terminal domain (amino acids 14-150) of a human liver form of…”
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A novel UDP-Glc-specific glucosyltransferase catalyzing the biosynthesis of 6-O-glucosides of bile acids in human liver microsomes by Radominska, A, Little, J, Pyrek, J S, Drake, R R, Igari, Y, Fournel-Gigleux, S, Magdalou, J, Burchell, B, Elbein, A D, Siest, G

“…Two active site-directed photoaffinity analogs, 5-[beta-32P]azido-UDP-glucuronic acid and 5-[beta-32P]azido-UDP-glucose, were used for the characterization of…”
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A proposed nomenclature for bile acids by Hofmann, AF, Sjövall, J, Kurz, G, Radominska, A, Schteingart, CD, Tint, GS, Vlahcevic, ZR, Setchell, KD

“…A proposal is made for a system of nomenclature of the more common unconjugated and conjugated bile acids. Acceptable trivial names for bile acids are…”
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Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia by Kuipers, F, Radominska, A, Zimniak, P, Little, J M, Havinga, R, Vonk, R J, Lester, R

“…Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY…”
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Chemical modification of human UDP-glucuronosyltransferase UGT16 by diethyl pyrocarbonate: possible involvement of a histidine residue in the catalytic process by Battaglia, E, Pritchard, M, Ouzzine, M, Fournel-Gigleux, S, Radominska, A, Siest, G, Magdalou, J

“…Chemical modification with diethyl pyrocarbonate (DEPC) of the recombinant human liver UDP-glucuronosyltransferase UGT1*6 in enriched membrane fractions from a…”
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Application of 5-azido-UDP-glucose and 5-azido-UDP-glucuronic acid photoaffinity probes for the determination of the active site orientation of microsomal UDP-glucosyltransferases and UDP-glucuronosyltransferases by DRAKE, R. R, IGARI, Y, LESTER, R, ELBEIN, A. D, RADOMINSKA, A

“…A new approach to determining the active site orientation of microsomal glycosyltransferases is presented which utilizes the photoaffinity analogs…”
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Characterization of human liver microsomal UDP-glycosyltransferases using photoaffinity analogs by Little, J M, Drake, R R, Vonk, R, Kuipers, F, Lester, R, Radominska, A

“…The photoaffinity analogs [beta-32P]5-azido-UDP-glucuronic acid ([32P]5N3UDP-GlcUA) and [beta-32P]5-azido-UDP-glucose ([32P]5N3UDP-Glc) were used to…”
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Determination of the human liver UDP-glucuronosyltransferase 2B4 domains involved in the binding of UDP-glucuronic acid using photoaffinity labeling of fusion proteins by Pillot, T, Ouzzine, M, Fournel-Gigleux, S, Lafaurie, C, Tebbi, D, Treat, S, Radominska, A, Lester, R, Siest, G, Magdalou, J

“…The interactions between UDP-glucuronic acid and two human liver UDP-glucuronosyltransferase 2B4 peptides (14-150 and 299-446) purified from E. coli as…”
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Synthesis and characterization of a new class of inhibitors of membrane-associated UDP-glycosyltransferases by PAUL, P, LUTZ, T. M, OSBORN, C, KYOSSEVA, S, ELBEIN, A. D, TOWBIN, H, RADOMINSKA, A, DRAKE, R. R

“…A new class of compounds designed to inhibit membrane-associated glycosyltransferases were synthesized and their biological activities were characterized in…”
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Synthesis and characterization of 5-azido-UDP-glucuronic acid. A new photoaffinity probe for UDP-glucuronic acid-utilizing proteins by DRAKE, R. R, ZIMNIAK, P, HALEY, B. E, LESTER, R, ELBEIN, A. D, RADOMINSKA, A

“…A new active site-directed photoaffinity analogue, [beta-32P]5-azido-UDP-glucuronic acid (UDP-GlcA), was enzymatically synthesized from [beta-32P]5-N3UDP-Glc…”
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Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions by OUDE ELFERINK, R. P. J, OTTENHOFF, R, RADOMINSKA, A, HOFMANN, A. F, KUIPERS, F, JANSEN, P. L. M

“…The effect of a spectrum of organic compounds on the secretion of a model organic anion, dinitrophenylglutathione (GS-DNP), by hepatocytes was tested. Previous…”
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Detoxification of lithocholic acid. Elucidation of the pathways of oxidative metabolism in rat liver microsomes by Zimniak, P, Holsztynska, E J, Lester, R, Waxman, D J, Radominska, A

“…The hydroxylation of lithocholic acid (3 alpha-hydroxy-5 beta-cholanoic acid) by adult male Sprague-Dawley rat liver microsomes supplemented with NADPH was…”
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Glucuronides of monohydroxylated bile acids: specificity of microsomal glucuronyltransferase for the glucuronidation site, C-3 configuration, and side chain length by Radomińska-Pyrek, A, Zimniak, P, Chari, M, Golunski, E, Lester, R, St Pyrek, J

“…The ability of rat liver microsomes to catalyze UDP-glucuronic acid-dependent glucuronidation of monohydroxy-bile acids was examined. The following bile acids…”
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Formation of three types of glucuronides of 6-hydroxy bile acids by rat liver microsomes by Zimniak, P, Radominska, A, Zimniak, M, Lester, R

“…The glucuronidation of 6-hydroxylated bile acids by rat liver microsomes was studied in vitro; for comparison, several major bile acids lacking a hydroxyl…”
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Purification and characterization of a catalytically active human liver UDP-glucuronosyltransferase expressed as a fusion protein in E. coli by Pillot, T, Ouzzine, M, Fournel-Gigleux, S, Lafaurie, C, Radominska, A, Lester, R, Drake, R, Treat, S, Siest, G, Magdalou, J

“…The purification and the characterization of functional human liver UDP-glucuronosyltransferase 2B4 produced as a Staphylococcus aureus protein A fusion…”
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Glucuronidation of monohydroxylated short chain bile acids by human liver microsomes and purified human liver UDP-glucuronosyltransferases by Irshaid, Y M, Radominska, A, Zimniak, P, Zimniak, A, Lester, R, Tephly, T R

“…The glucuronidation of monohydroxylated bile acids and their analogs with a shortened side chain (short-chain bile acids) by human liver microsomes and by two…”
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Hepatic metabolism of short-chain bile acids. Inversion of the 3-hydroxyl group of isoetianic acid (3 beta-hydroxy-5 beta-androstane-17 beta-carboxylic acid) by the adult rat by Little, JM, Pyrek, JS, Radominska, A, Shattuck, KE, Lester, R

“…The stereospecificity of mechanisms for hepatic transport of short-chain bile acids has been examined by following the hepatic metabolism and biliary secretion…”
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