Search Results - "Radmacher, M D"

Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification by Simon, Richard, Radmacher, Michael D., Dobbin, Kevin, McShane, Lisa M.

“…Many studies profiling gene expression in human cancers have been completed and are in progress. Some studies (19-22) attempt to build predictors of patient…”
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The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia by Whitman, S P, Caligiuri, M A, Maharry, K, Radmacher, M D, Kohlschmidt, J, Becker, H, Mrózek, K, Wu, Y-Z, Schwind, S, Metzeler, K H, Mendler, J H, Wen, J, Baer, M R, Powell, B L, Carter, T H, Kolitz, J E, Wetzler, M, Carroll, A J, Larson, R A, Marcucci, G, Bloomfield, C D

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Estimation of tamoxifen's efficacy for preventing the formation and growth of breast tumors by RADMACHER, M. D, SIMON, R

“…Several randomized clinical trials have tested the hypothesis that tamoxifen is effective in preventing breast cancer. The largest such trial, the National…”
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Graph Models of Oncogenesis with an Application to Melanoma by RADMACHER, MICHAEL D, SIMON, RICHARD, DESPER, RICHARD, TAETLE, RAYMOND, SCHÄFFER, ALEJANDRO A, NELSON, MARK A

“…We describe several analytical techniques for use in developing genetic models of oncogenesis including: methods for the selection of important genetic events,…”
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Predicted and inferred waiting times for key mutations in the germinal centre reaction: Evidence for stochasticity in selection by Radmacher, Michael D, Kelsoe, Garnett, Kepler, Thomas B

“…The germinal centre reaction (GCR) is a fundamental component of the immune response to T‐dependent antigens, during which the immunoglobulin (Ig) genes of B…”
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Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study by Radmacher, Michael D., Marcucci, Guido, Ruppert, Amy S., Mrózek, Krzysztof, Whitman, Susan P., Vardiman, James W., Paschka, Peter, Vukosavljevic, Tamara, Baldus, Claudia D., Kolitz, Jonathan E., Caligiuri, Michael A., Larson, Richard A., Bloomfield, Clara D.

“…Patients with acute myeloid leukemia (AML) and normal karyotype are classified in an intermediate-risk group, albeit this subset is heterogeneous for clinical…”
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Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood by Radmacher, Michael D., Kepler, Thomas B.

“…The germinal center reaction (GCR) of vertebrate immunity provides a remarkable example of evolutionary succession, in which an advantageous phenotype arises…”
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Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8 by Becker, H, Maharry, K, Mrózek, K, Volinia, S, Eisfeld, A-K, Radmacher, M D, Kohlschmidt, J, Metzeler, K H, Schwind, S, Whitman, S P, Mendler, J H, Wu, Y-Z, Nicolet, D, Paschka, P, Powell, B L, Carter, T H, Wetzler, M, Kolitz, J E, Carroll, A J, Baer, M R, Caligiuri, M A, Stone, R M, Marcucci, G, Bloomfield, C D

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Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study by BECKER, Heiko, MAHARRY, Kati, CARTER, Thomas H, KOLITZ, Jonathan E, WETZLER, Meir, CARROLL, Andrew J, BAER, Maria R, MOORE, Joseph O, CALIGIURI, Michael A, LARSON, Richard A, MARCUCCI, Guido, BLOOMFIELD, Clara D, RADMACHER, Michael D, MROZEK, Krzysztof, METZELER, Klaus H, WHITMAN, Susan P, SCHWIND, Sebastian, KOHLSCHMIDT, Jessica, WU, Yue-Zhong, POWELL, Bayard L

“…The alleles of the Wilms tumor 1 (WT1) polymorphism rs16754 harbor adenine (A) or guanine (G). Recently, rs16754 has been reported to affect the outcome of…”
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NPM1 mutations as an independent prognosticator for older cytogenetically normal acute myeloid leukemia (CN AML) by Becker, H., Marcucci, G., Maharry, K., Margeson, D., Radmacher, M. D., Whitman, S. P., Mrózek, K., Baer, M. R., Larson, R. A., Bloomfield, C. D.

“…Abstract only 7000 Background: In younger CN AML without FLT3-ITD, NPM1 mutations predict favorable outcome. Their prognostic impact in older [≥60 years (y)]…”
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MicroRNA 181a ( miR-181a ) expression as a prognosticator in cytogenetically normal acute myeloid leukemia (CN AML) by Schwind, S., Marcucci, G., Maharry, K., Radmacher, M. D., Whitman, S. P., Paschka, P., Mrózek, K., Kolitz, J. E., Larson, R. A., Bloomfield, C. D.

“…Abstract only 7001 Background: We showed recently that CEBPA mutations (mut) in CN AML are associated with better outcome and a unique microRNA expression…”
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FLT3 D835/I836 mutations predict worse disease-free survival (DFS) in younger adults with cytogenetically normal acute myeloid leukemia (CN AML) without FLT3 internal tandem duplications (ITD): A Cancer and Leukemia Group B (CALGB) study by Whitman, S. P., Ruppert, A. S., Radmacher, M. D., Mrozek, K., Paschka, P., Kolitz, J. E., Larson, R. A., Caligiuri, M. A., Marcucci, G., Bloomfield, C. D.

“…Abstract only 10532 Background: The adverse prognostic impact of FLT3 ITD is well-recognized in younger adults with CN AML, whereas the clinical relevance of…”
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High BAALC expression associates with other molecular prognostic markers, poor outcome and a distinct gene expression signature in cytogenetically normal acute myeloid leukemia (CN AML): A Cancer and Leukemia Group B (CALGB) study by Langer, C., Ruppert, A. S., Radmacher, M. D., Whitman, S. P., Paschka, P., Baldus, C. D., Mrózek, K., Kolitz, J. E., Marcucci, G., Bloomfield, C. D.

“…Abstract only 7013 Background: High BAALC expression predicts poor outcome in CN AML patients (pts). Yet, little is known about BAALC's function or its…”
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Outcome prediction in adult core binding factor (CBF) acute myeloid leukemia (AML) with gene expression profiling: A Cancer and Leukemia Group B (CALGB) study by Paschka, P., Radmacher, M. D., Marcucci, G., Ruppert, A. S., Vukosavljevic, T., Whitman, S. P., Mrózek, K., Liu, C., Larson, R. A., Bloomfield, C. D.

“…Abstract only 7011 Background: In CBF AML with t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22) [abbreviated inv(16)], KIT mutations (mutKIT) and, in…”
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MicroRNA (miR) expression signatures in molecular subsets of cytogenetically normal (CN) acute myeloid leukemia (AML): A Cancer and Leukemia Group B (CALGB) study by Radmacher, M. D., Marcucci, G., Paschka, P., Vukosavljevic, T., Whitman, S. P., Ruppert, A. S., Mrózek, K., Kolitz, J. E., Larson, R. A., Bloomfield, C. D.

“…Abstract only 7010 Background: Aberrantly expressed miRs contribute to malignant transformation by hybridizing to specific mRNA targets and suppressing their…”
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Overexpression of the ETS-Related Gene, ERG, Predicts a Worse Outcome in Acute Myeloid Leukemia With Normal Karyotype: A Cancer and Leukemia Group B Study by MARCUCCI, Guido, BALDUS, Claudia D, BAER, Maria R, MOORE, Joseph O, PERROTTI, Danilo, CALIGIURI, Michael A, CARROLL, Andrew J, LARSON, Richard A, DE LA CHAPELLE, Albert, BLOOMFIELD, Clara D, RUPPERT, Amy S, RADMACHER, Michael D, MROZEK, Krzysztof, WHITMAN, Susan P, KOLITZ, Jonathan E, EDWARDS, Colin G, VARDIMAN, James W, POWELL, Bayard L

“…To test the prognostic significance of ETS-related gene (ERG) expression in cytogenetically normal primary acute myeloid leukemia (AML). Pretreatment blood…”
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A paradigm for class prediction using gene expression profiles by Radmacher, Michael D, McShane, Lisa M, Simon, Richard

“…We propose a general framework for prediction of predefined tumor classes using gene expression profiles from microarray experiments. The framework consists of…”
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Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces by Kim, Jonghan, Bronson, C L, Hayton, William L, Radmacher, Michael D, Roopenian, Derry C, Robinson, John M, Anderson, Clark L

“…It is now understood that the nonclassical major histocompatibility complex-I molecule FcRn binds albumin and retrieves it from an intracellular degradative…”
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Design of studies using DNA microarrays by Simon, Richard, Radmacher, Michael D., Dobbin, Kevin

“…DNA microarrays are assays that simultaneously provide information about expression levels of thousands of genes and are consequently finding wide use in…”
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Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data by McShane, Lisa M., Radmacher, Michael D., Freidlin, Boris, Yu, Ren, Li, Ming-Chung, Simon, Richard

“…Motivation: Recent technological advances such as cDNA microarray technology have made it possible to simultaneously interrogate thousands of genes in a…”
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