Search Results - "Radley, Arthur"

Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activation by Corujo-Simon, Elena, Radley, Arthur H, Nichols, Jennifer

“…Successful human pregnancy depends upon rapid establishment of three founder lineages: the trophectoderm, epiblast and hypoblast, which together form the…”
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Entropy sorting of single-cell RNA sequencing data reveals the inner cell mass in the human pre-implantation embryo by Radley, Arthur, Corujo-Simon, Elena, Nichols, Jennifer, Smith, Austin, Dunn, Sara-Jane

“…A major challenge in single-cell gene expression analysis is to discern meaningful cellular heterogeneity from technical or biological noise. To address this…”
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Assessment of engineered cells using CellNet and RNA-seq by Radley, Arthur H, Schwab, Remy M, Tan, Yuqi, Kim, Jeesoo, Lo, Emily K W, Cahan, Patrick

“…CellNet is a computational platform designed to improve cell fate engineering protocols. Here the authors demonstrate how to apply CellNet to RNA-seq data and…”
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Branching topology of the human embryo transcriptome revealed by Entropy Sort Feature Weighting by Radley, Arthur, Boeing, Stefan, Smith, Austin

“…Analysis of single cell transcriptomics (scRNA-seq) data is typically performed after subsetting to highly variable genes (HVGs). Here, we show that Entropy…”
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Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification by Dattani, Anish, Corujo-Simon, Elena, Radley, Arthur, Heydari, Tiam, Taheriabkenar, Yasaman, Carlisle, Francesca, Lin, Simeng, Liddle, Corin, Mill, Jonathan, Zandstra, Peter W, Nichols, Jennifer, Guo, Ge

“…The hypoblast is an essential extraembryonic tissue set aside within the inner cell mass in the blastocyst. Research with human embryos is challenging. Thus,…”
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Assessing engineered cells using CellNet and RNA-Seq by Radley, Arthur H, Schwab, Remy M, Tan, Yuqi, Kim, Jeesoo, Lo, Emily KW, Cahan, Patrick

“…CellNet is a computational platform designed to assess cell populations engineered via either directed differentiation of pluripotent stem cells or via direct…”
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Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function by Luo, Jingchuan, Vale-Silva, Luis A, Raghavan, Adhithi R, Mercy, Guillaume, Heldrich, Jonna, Sun, Xiaoji, Li, Mingyu Kenneth, Zhang, Weimin, Agmon, Neta, Yang, Kun, Cai, Jitong, Stracquadanio, Giovanni, Thierry, Agnès, Zhao, Yu, Coelho, Camila, McCulloch, Laura H, Lauer, Stephanie, Kaback, David B, Bader, Joel S, Mitchell, Leslie A, Mozziconacci, Julien, Koszul, Romain, Hochwagen, Andreas, Boeke, Jef D

“…We designed and synthesized , which is ∼21.6% shorter than native , the smallest chromosome in . was designed for attachment to another synthetic chromosome…”
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Naval security by Radley, Arthur

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Horror of Dresden by RADLEY, ARTHUR

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