Search Results - "Radler, Megan R."

Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner by Nakos, Konstantinos, Radler, Megan R, Spiliotis, Elias T

“…Septins (SEPTs) are filamentous guanosine-5'-triphosphate (GTP)-binding proteins, which affect microtubule (MT)-dependent functions including membrane…”
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In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA by La Rocca, Gaspare, Olejniczak, Scott H., González, Alvaro J., Briskin, Daniel, Vidigal, Joana A., Spraggon, Lee, DeMatteo, Raymond G., Radler, Megan R., Lindsten, Tullia, Ventura, Andrea, Tuschl, Thomas, Leslie, Christina S., Thompson, Craig B.

“…MicroRNAs repress mRNA translation by guiding Argonaute proteins to partially complementary binding sites, primarily within the 3′ untranslated region (UTR) of…”
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Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity by Finley, Lydia W. S., Vardhana, Santosha A., Carey, Bryce W., Alonso-Curbelo, Direna, Koche, Richard, Chen, Yanyang, Wen, Duancheng, King, Bryan, Radler, Megan R., Rafii, Shahin, Lowe, Scott W., Allis, C. David, Thompson, Craig B.

“…A robust network of transcription factors and an open chromatin landscape are hallmarks of the naive pluripotent state. Recently, the acetyllysine reader Brd4…”
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Right place, right time - Spatial guidance of neuronal morphogenesis by septin GTPases by Radler, Megan R., Spiliotis, Elias T.

“…Neuronal morphogenesis is guided by outside-in signals and inside-out mechanisms, which require spatiotemporal precision. How the intracellular mechanisms of…”
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Spatial control of membrane traffic in neuronal dendrites by Radler, Megan R., Suber, Ayana, Spiliotis, Elias T.

“…Neuronal dendrites are highly branched and specialized compartments with distinct structures and secretory organelles (e.g., spines, Golgi outposts), and a…”
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Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation by Radler, Megan R., Liu, Xiaonan, Peng, Megan, Doyle, Brenna, Toyo-Oka, Kazuhito, Spiliotis, Elias T.

“…Pyramidal neurons are a major cell type of the forebrain, consisting of a pyramidally shaped soma with axonal and apicobasal dendritic processes. It is poorly…”
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Independent translation of ORFs in dicistronic operons, synthetic building blocks for polycistronic chloroplast gene expression by Yu, Qiguo, Tungsuchat‐Huang, Tarinee, Verma, Kanak, Radler, Megan R., Maliga, Pal

“…SUMMARY We designed a dicistronic plastid marker system that relies on the plastid's ability to translate polycistronic mRNAs. The identification of…”
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Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules by Nakos, Konstantinos, Alam, Md Noor A, Radler, Megan R, Kesisova, Ilona A, Yang, Changsong, Okletey, Joshua, Tomasso, Meagan R, Padrick, Shae B, Svitkina, Tatyana M, Spiliotis, Elias T

“…Cellular morphogenesis and processes such as cell division and migration require the coordination of the microtubule and actin cytoskeletons. Microtubule-actin…”
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Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways by Olejniczak, Scott H., La Rocca, Gaspare, Radler, Megan R., Egan, Shawn M., Xiang, Qing, Garippa, Ralph, Thompson, Craig B.

“…Cell growth and proliferation require the coordinated activation of many cellular processes, including cap-dependent mRNA translation. MicroRNAs oppose…”
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The Septin Cytoskeleton Is Required for Morphogenesis of Pyramidal Neurons by Radler, Megan R

“…Neurons are dramatically polarized cells, and are the functional subunit of the nervous system. Their polarized morphology is crucial to their function…”
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