Preliminary Microbiological Tests of S-Carvone and Geraniol and Selected Derivatives of These Compounds That May Be Formed in the Processes of Isomerization and Oxidation

This work presents a literature review on the biological activity of S-carvone, geraniol and derivatives of these compounds, which are formed in the process of isomerization (during the process of geraniol isomerization, oxidation products of this compound are also obtained). Moreover, this work pre...

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Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 20; p. 7012
Main Authors:	Wróblewska, Agnieszka, Fajdek-Bieda, Anna, Markowska-Szczupak, Agata, Radkowska, Monika
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 18-10-2022 MDPI
Subjects:	Antibiotics Antimicrobial agents Antioxidants Bacteria Bioactive compounds Biofilms Biological activity Cancer therapies Carvacrol Carvone Citral Coliforms Composition Contact angle E coli Escherichia coli Fungi geraniol Gram-negative bacteria Gram-positive bacteria Immune system Investigations Isomerization Linalool Literature reviews Microbiology Microorganisms Mixtures Molds (Fungi) Molecular weight Nanoparticles natural preservatives nerol Oils & fats Oxidation Oxidation-reduction reaction Review S-carvone Seeds Staphylococcus infections Streptococcus infections Urinary tract diseases Urinary tract infections Urogenital system Poland
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Summary:	This work presents a literature review on the biological activity of S-carvone, geraniol and derivatives of these compounds, which are formed in the process of isomerization (during the process of geraniol isomerization, oxidation products of this compound are also obtained). Moreover, this work presents preliminary microbiological tests of creams with the addition of these biologically active compounds: S-carvone, geraniol, carvacrol (an S-carvone isomerization product), nerol (a geraniol isomerization product), linalool (a geraniol isomerization product) and citral (a geraniol oxidation product). Because the post-reaction mixture obtained after the S-carvone isomerization has a relatively simple composition, it was also added to creams and tested without isolating pure compounds. This may be a cheaper alternative to creams prepared with the addition of pure compounds. The mixture obtained after the geraniol isomerization process has a very complex composition; therefore, only compounds with the lowest molecular weight and are easily commercially available were selected for studies. The content of the tested compounds in the creams ranged from 0.5 to 3 wet%. The following microorganisms were selected for microbiological tests: the Gram-negative bacterium Escherichia coli K12, the Gram-positive bacterium Staphylococcus epidermidis, and the fungi Candida albicans, Trichophyton rubrum, Aspergillus niger, and Penicillium chrysogenum. A content of 3% carvacrol, nerol, geraniol and citral inhibited the growth of E. coli, and attenuated the growth of C. albicans and T. rubrum. On the other hand, 3% carvacrol and citral only poorly attenuated the growth of the mould fungi P. chrysogenum and A. niger.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27207012