Search Results - "Radio, Nicholas M."

Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening by Radio, Nicholas M., Breier, Joseph M., Shafer, Timothy J., Mundy, William R.

“…Identification of chemicals that pose a hazard to the developing nervous system is the first step in reducing human exposure and preventing health risks to…”
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Development of a High-Throughput Screening Assay for Chemical Effects on Proliferation and Viability of Immortalized Human Neural Progenitor Cells by Breier, Joseph M., Radio, Nicholas M., Mundy, William R., Shafer, Timothy J.

“…There is considerable public concern that the majority of commercial chemicals have not been evaluated for their potential to cause developmental…”
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Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria by Davis, Vicki L, Abukabda, Alaeddin B, Radio, Nicholas M, Witt-Enderby, Paula A, Clafshenkel, William P, Cairone, J Vito, Rutkowski, James L

“…Multiple platelet-rich preparations have been reported to improve wound and bone healing, such as platelet-rich plasma (PRP) and platelet rich fibrin (PRF)…”
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Neuronal models for evaluation of proliferation in vitro using high content screening by Mundy, William R, Radio, Nicholas M, Freudenrich, Theresa M

“…Abstract In vitro test methods can provide a rapid approach for the screening of large numbers of chemicals for their potential to produce toxicity ( hazard…”
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Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis by Radio, Nicholas M, Freudenrich, Theresa M, Robinette, Brian L, Crofton, Kevin M, Mundy, William R

“…Abstract Development of high-throughput assays for chemical screening and hazard identification is a pressing priority worldwide. One approach uses in vitro ,…”
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Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin by Harrill, Joshua A, Li, Zhen, Wright, Fred A, Radio, Nicholas M, Mundy, William R, Tornero-Velez, Rogelio, Crofton, Kevin M

“…Pyrethroids are neurotoxic pesticides that interact with membrane bound ion channels in neurons and disrupt nerve function. The purpose of this study was to…”
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Developmental neurotoxicity testing in vitro: Models for assessing chemical effects on neurite outgrowth by Radio, Nicholas M., Mundy, William R.

“…In vitro models may be useful for the rapid toxicological screening of large numbers of chemicals for their potential to produce toxicity. Such screening could…”
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Analysis of a rapid, simple, and inexpensive technique used to obtain platelet-rich plasma for use in clinical practice by Rutkowski, James L, Thomas, Joseph M, Bering, C Larry, Speicher, Julie L, Radio, Nicholas M, Smith, Douglas M, Johnson, David A

“…The use of platelet-rich plasma (PRP) has become more generally accepted, and implant dentists are using PRP more frequently to promote the healing of oral…”
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Modulation of melatonin receptors and G-protein function by microtubules by Jarzynka, Michael J., Passey, Deepshikha K., Ignatius, Paul F., Melan, Melissa A., Radio, Nicholas M., Jockers, Ralf, Rasenick, Mark M., Brydon, Lena, Witt-Enderby, Paula A.

“…:  Chronic melatonin exposure produces microtubule rearrangements in Chinese hamster ovary (CHO) cells expressing the human MT1 melatonin receptor while at the…”
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Expanding the test set: Chemicals with potential to disrupt mammalian brain development by Mundy, William R, Padilla, Stephanie, Breier, Joseph M, Crofton, Kevin M, Gilbert, Mary E, Herr, David W, Jensen, Karl F, Radio, Nicholas M, Raffaele, Kathleen C, Schumacher, Kelly, Shafer, Timothy J, Cowden, John

“…Abstract High-throughput test methods including molecular, cellular, and alternative species-based assays that examine critical events of normal brain…”
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Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade by Radio, Nicholas M., Doctor, John S., Witt-Enderby, Paula A.

“…:  The goals of this study were to determine (a) if melatonin enhances human adult mesenchymal stem cell (hAMSC) differentiation into osteoblasts as assessed…”
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Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways by Sethi, Shalini, Radio, Nicholas M., Kotlarczyk, Mary P., Chen, Chien-Tsun, Wei, Yau-Huei, Jockers, Ralf, Witt-Enderby, Paula A.

“…:  The purpose of this study was to determine the critical time periods of melatonin treatment required to induce human mesenchymal stem cells (hAMSCs) into…”
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Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy by Witt-Enderby, Paula A., Radio, Nicholas M., Doctor, John S., Davis, Vicki L.

“…:  Melatonin's therapeutic potential is grossly underestimated because its functional roles are diverse and its mechanism(s) of action are complex and varied…”
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Platelet-rich preparations to improve healing. Part I: workable options for every size practice by Davis, Vicki L, Abukabda, Alaeddin B, Radio, Nicholas M, Witt-Enderby, Paula A, Clafshenkel, William P, Cairone, J Vito, Rutkowski, James L

“…Numerous studies have demonstrated that platelet-rich preparations applied to surgical sites, injuries, or wounds are a safe and effective way to promote soft…”
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Platelet rich plasma to facilitate wound healing following tooth extraction by Rutkowski, James L, Johnson, David A, Radio, Nicholas M, Fennell, James W

“…Following tooth removal bone formation normally takes 16 weeks and may result in less than adequate volume for the necessary reconstruction. Platelet rich…”
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Neurite outgrowth assessment using high content analysis methodology by Radio, Nicholas M

“…High content analysis of neurite outgrowth enables the rapid and comprehensive phenotypic assessment of individual neurons in a multiwell format amenable to…”
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Protein biomarkers associated with growth and synaptogenesis in a cell culture model of neuronal development by Mundy, William R, Robinette, Brian, Radio, Nicholas M, Freudenrich, Theresa M

“…Abstract Cerebellar granule cells (CGC) provide a homogenous population of cells which can be used as an in vitro model for studying the cellular processes…”
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Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: in vitro and in vivo evidence by Jarzynka, Michael J., Passey, Deepshikha K., Johnson, David A., Konduru, Nagarjun V., Fitz, Nicholas F., Radio, Nicholas M., Rasenick, Mark, Benloucif, Susan, Melan, Melissa A., Witt-Enderby, Paula A.

“…:  MT1 melatonin receptors expressed in Chinese hamster ovary (CHO) cells remain sensitive to a melatonin re‐challenge even following chronic melatonin…”
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Neuropilin-2 Isoforms Regulate Distinct Functions of Tumor-associated Macrophages in Breast Cancer by Soloff, Adam C, Stanton, Rebecca A., Radio, Nicholas M., Freilino-Glunt, Maria, Nasarre, Cecile, Dimou, Anastasios, Nasarre, Patrick, Denlinger, Chadrick E., Oesterreich, Steffi, Lee, Adrian V., Lotze, Michael T., Dhupar, Rajeev, Gemmill, Robert

“…Abstract Introduction Neuropilins are neural guidance molecules which contribute to tissue development. We have shown that the two isoforms of neuropilin-2…”
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Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways: Chronic melatonin induces osteoblast formation by Sethi, Shalini, Radio, Nicholas M., Kotlarczyk, Mary P., Chen, Chien-Tsun, Wei, Yau-Huei, Jockers, Ralf, Witt-Enderby, Paula A.

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