Search Results - "Radhakrishnan, Jeejabai"

Sodium-Hydrogen Exchanger Isoform-1 Inhibition: A Promising Pharmacological Intervention for Resuscitation from Cardiac Arrest by Gazmuri, Raúl J, Radhakrishnan, Jeejabai, Ayoub, Iyad M

“…Out-of-hospital sudden cardiac arrest is a major public health problem with an overall survival of less than 5%. Upon cardiac arrest, cessation of coronary…”
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Enhanced Oxygen Utilization Efficiency With Concomitant Activation of AMPK-TBC1D1 Signaling Nexus in Cyclophilin-D Conditional Knockout Mice by Radhakrishnan, Jeejabai, Baetiong, Alvin, Gazmuri, Raúl J

“…We have previously reported in HEK 293 T cells and in constitutive cyclophilin-D (Cyp-D) knockout (KO) mice that Cyp-D ablation downregulates oxygen…”
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Targeted Delivery of Electrical Shocks and Epinephrine, Guided by Ventricular Fibrillation Amplitude Spectral Area, Reduces Electrical and Adrenergic Myocardial Burden, Improving Survival in Swine by Aiello, Salvatore R, Mendelson, Jenna B, Baetiong, Alvin, Radhakrishnan, Jeejabai, Gazmuri, Raúl J

“…Background We previously reported that resuscitation delivering electrical shocks guided by real-time ventricular fibrillation amplitude spectral area (AMSA)…”
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Ventricular Fibrillation Waveform Changes during Controlled Coronary Perfusion Using Extracorporeal Circulation in a Swine Model by Gazmuri, Raúl J, Kaufman, Christopher L, Baetiong, Alvin, Radhakrishnan, Jeejabai

“…Several characteristics of the ventricular fibrillation (VF) waveform have been found predictive of successful defibrillation and hypothesized to reflect the…”
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Targeting mitochondria for resuscitation from cardiac arrest by AYOUB, Iyad M, RADHAKRISHNAN, Jeejabai, GAZMURI, Raul J

“…Reversal of cardiac arrest requires reestablishment of aerobic metabolism by reperfusion with oxygenated blood of tissues that have been ischemic for variable…”
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Vasopressin Infusion with Small-Volume Fluid Resuscitation during Hemorrhagic Shock Promotes Hemodynamic Stability and Survival in Swine by Gazmuri, Raúl J, Whitehouse, Kasen, Whittinghill, Karla, Baetiong, Alvin, Radhakrishnan, Jeejabai

“…Current management of hemorrhagic shock (HS) in the battlefield and civilian settings favors small-volume fluid resuscitation before controlling the source of…”
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Real‐Time Ventricular Fibrillation Amplitude‐Spectral Area Analysis to Guide Timing of Shock Delivery Improves Defibrillation Efficacy During Cardiopulmonary Resuscitation in Swine by Aiello, Salvatore, Perez, Michelle, Cogan, Chad, Baetiong, Alvin, Miller, Steven A., Radhakrishnan, Jeejabai, Kaufman, Christopher L., Gazmuri, Raúl J.

“…Background The ventricular fibrillation amplitude spectral area (AMSA) predicts whether an electrical shock could terminate ventricular fibrillation and prompt…”
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Protecting Mitochondrial Bioenergetic Function During Resuscitation from Cardiac Arrest by Gazmuri, Raúl J., MD, PhD, FCCM, Radhakrishnan, Jeejabai, PhD

“…Successful resuscitation from cardiac arrest requires reestablishment of aerobic metabolism by reperfusion with oxygenated blood of tissues that have been…”
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Plasma Cytochrome c Detection Using a Highly Sensitive Electrochemiluminescence Enzyme-Linked Immunosorbent Assay by Radhakrishnan, Jeejabai, Origenes, Rovi, Littlejohn, Gina, Nikolich, Sanja, Choi, Eunjung, Smite, Sharon, Lamoureux, Lorissa, Baetiong, Alvin, Shah, Manoj, Gazmuri, Raúl J

“…BACKGROUND: Cytochrome c is an intermembrane mitochondrial protein that is released to the bloodstream following mitochondrial injury. METHODS AND RESULTS: We…”
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Effects of intraosseous erythropoietin during hemorrhagic shock in swine by Borovnik-Lesjak, Vesna, Whitehouse, Kasen, Baetiong, Alvin, Miao, Yang, Currie, Brian M, Velmurugan, Sathya, Radhakrishnan, Jeejabai, Gazmuri, Raúl J

“…To determine whether erythropoietin given during hemorrhagic shock (HS) ameliorates organ injury while improving resuscitation and survival. Three series of 24…”
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Abstract 11036: Enhanced Oxygen Utilization Efficiency with Concomitant Activation of the AMPK-TBC1D1 Signaling Nexus in Cyclophilin-D Conditional Knock-Out Mice by Radhakrishnan, Jeejabai, Baetiong, Alvin, Gazmuri, Raul J

“…We have previously reported in HEK 293T cells and in constitutive cyclophilin-D (Cyp-D) knock-out (KO) mice that Cyp-D ablation downregulates oxygen…”
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193: CYCLOSPORINE A MAY DISRUPT MITOCHONDRIAL GENE EXPRESSION IN HUMAN LEFT VENTRICULAR CARDIOMYOCYTES by Radhakrishnan, Jeejabai, Gazmuri, Raúl

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Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart by Rajan, Sudarsan, Radhakrishnan, Jeejabai, Rajamanickam, Chellam

“…Earlier studies from this laboratory have shown that the serum protein of molecular weight of 182 kDa, which plays an indispensable role in the development of…”
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Abstract 10911: Amplitude Spectral Area to Guide Shock and Epinephrine Delivery in a Swine Model of Ventricular Fibrillation and Closed-Chest Resuscitation by Aiello, Salvatore, Mendelson, Jenna, Baetiong, Alvin, Radhakrishnan, Jeejabai, Gazmuri, Raul J

“…IntroductionVF accounts for ~30% of all sudden cardiac arrest episodes. VF signal analysis in the frequency domain - calculating the amplitude spectral area…”
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Abstract 16765: Cyclophilin-D: A Regulator of Mitochondrial Gene Expression by Radhakrishnan, Jeejabai, Gazmuri, Raúl J

“…Abstract only Background: Cyclophilin-D (Cyp-D) is a peptidyl-prolyl isomerase resident in the mitochondrial matrix; and like other cyclophilins it can…”
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Abstract 143: The Modified Shock Index Separates Survivors from Non-Survivors in a Swine Model of Hemorrhagic Shock and Traumatic Brain Injury by Mendelson, Jenna, Maggio, Matt, Aiello, Salvatore, Radhakrishnan, Jeejabai, Baetiong, Alvin, Gazmuri, Raul J

“…Abstract only The ratio between heart rate and arterial blood pressure during hemorrhagic shock has been shown useful to identify individuals at risk of death…”
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Constitutive cyclophilin-D ablation in mice increases exercise and cognitive-behavioral performance under normoxic and hypoxic conditions by Radhakrishnan, Jeejabai, Baetiong, Alvin, Gazmuri, Raúl J.

“…•Cyclophilin-D (Cyp-D) is a mitochondrial peptidyl-prolyl isomerase.•Cyp-D ablation in mice improves exercise capacity with less oxygen utilization.•Cyp-D…”
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Abstract 257: Ventricular Fibrillation Amplitude Spectral Area to Assess the Myocardial Effect of Hemodynamic and Metabolic Interventions During Cardiac Resuscitation in a Rat Model by Aiello, Salvatore, Lamoureux, Lorissa, Baetiong, Alvin, Radhakrishnan, Jeejabai, Gazmuri, Raul J

“…Abstract only Introduction: The amplitude spectral area (AMSA) of ventricular fibrillation (VF) has been shown to track the myocardial energy state and to…”
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Abstract 176: Genetic Ablation of Cyclophilin-D in Mice Increases Physical and Cognitive Performance During Hypoxia by Radhakrishnan, Jeejabai, Baetiong, Alvin, Kaufman, Harrison, Huynh, Michelle, Leschinsky, Angela, Gazmuri, Raul J

“…Abstract only Introduction: We previously reported that silencing of the mitochondrial peptidyl-prolyl isomerase Cyclophilin-D (Cyp-D) in HEK 293T cells…”
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Cyclophilin-D: A Novel regulator of mitochondrial gene expression by Radhakrishnan, Jeejabai, Gazmuri, Raúl J.

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