Search Results - "Radford, S E"

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly by Woods, L.A., Radford, S.E., Ashcroft, A.E.

“…Interfacing ion mobility spectrometry to mass spectrometry (IMS–MS) has enabled mass spectrometric analyses to extend into an extra dimension, providing…”
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Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes by Aggeli, A, Bell, M, Boden, N, Keen, J. N, Knowles, P. F, McLeish, T. C. B, Pitkeathly, M, Radford, S. E

“…Molecular self-assembly is becoming an increasingly popular route to new supramolecular structures and molecular materials. The inspiration for such structures…”
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Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro by McParland, V J, Kad, N M, Kalverda, A P, Brown, A, Kirwin-Jones, P, Hunter, M G, Sunde, M, Radford, S E

“…Dialysis-related amyloidosis (DRA) involves the aggregation of beta(2)-microglobulin (beta(2)m) into amyloid fibrils. Using Congo red and thioflavin-T binding,…”
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Precipitable Water Vapor, Temperature, and Wind Statistics At Sites Suitable for mm and Submm Wavelength Astronomy in Northern Chile by Otarola, A., De Breuck, C., Travouillon, T., Matsushita, S., Nyman, L.- ., Wootten, A., Radford, S. J. E., Sarazin, M., Kerber, F., Pérez-Beaupuits, J. P.

“…Atmospheric water vapor is the main limiting factor of atmospheric transparency in the mm and submm wavelength spectral windows. Thus, dry sites are needed for…”
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Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis by Booth, David R, Sunde, Margaret, Bellotti, Vittorio, Robinson, Carol V, Hutchinson, Winston L, Fraser, Paul E, Hawkins, Philip N, Dobson, Christopher M, Radford, Sheena E, Blake, Colin C. F, Pepys, Mark B

“…Tissue deposition of soluble proteins as amyloid fibrils underlies a range of fatal diseases. The two naturally occurring human lysozyme variants are both…”
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The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis by Guthertz, N, van der Kant, R, Martinez, R M, Xu, Y, Trinh, C H, Iorga, B I, Rousseau, F, Schymkowitz, J, Brockwell, D J, Radford, S E

“…Aggregation of initially stably structured proteins is involved in more than 20 human amyloid diseases. Despite intense research, however, how this class of…”
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Multilayer Etched Antireflective Structures for Silicon Vacuum Windows by Macioce, T., Defrance, F., Jung-Kubiak, C., Rahiminejad, S., Sayers, J., Connors, J., Chattopadhyay, G., Golwala, S. R., Radford, S. J. E.

“…Future instruments employing cryogenic detectors for millimeter and submillimeter astronomy applications can benefit greatly from silicon vacuum windows with…”
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Molecular Gas in Extreme Star-Forming Environments: The Starbursts Arp 220 and NGC 6240 as Case Studies by Greve, T. R, Papadopoulos, P. P, Gao, Y, Radford, S. J. E

“…We report single-dish multitransition measurements of the 12CO, HCN, and HCO+ molecular line emission as well as HNC J = 1-0 and HNCO in the two ultraluminous…”
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Detection of Transient Protein Folding Populations by Mass Spectrometry by Miranker, Andrew, Robinson, Carol V., Radford, Sheena E., Aplin, Robin T., Dobson, Christopher M.

“…Hydrogen-deuterium exchange measurements are becoming increasingly important in studies of the dynamics of protein molecules and, particularly, of their…”
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The Molecular Interstellar Medium in Ultraluminous Infrared Galaxies by Solomon, P. M, Downes, D, Radford, S. J. E, Barrett, J. W

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Potential human transmission of amyloid β pathology: surveillance and risks by Lauwers, Elsa, Lalli, Giovanna, Brandner, Sebastian, Collinge, John, Compernolle, Veerle, Duyckaerts, Charles, Edgren, Gustaf, Haïk, Stéphane, Hardy, John, Helmy, Adel, Ivinson, Adrian J, Jaunmuktane, Zane, Jucker, Mathias, Knight, Richard, Lemmens, Robin, Lin, I-Chun, Love, Seth, Mead, Simon, Perry, V Hugh, Pickett, James, Poppy, Guy, Radford, Sheena E, Rousseau, Frederic, Routledge, Carol, Schiavo, Giampietro, Schymkowitz, Joost, Selkoe, Dennis J, Smith, Colin, Thal, Dietmar R, Theys, Tom, Tiberghien, Pierre, van den Burg, Peter, Vandekerckhove, Philippe, Walton, Clare, Zaaijer, Hans L, Zetterberg, Henrik, De Strooper, Bart

“…Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and…”
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The role of β‐barrels 1 and 2 in the enzymatic activity of factor XIII A‐subunit by Hethershaw, E. L., Adamson, P. J., Smith, K. A., Goldsberry, W. N., Pease, R. J., Radford, S. E., Grant, P. J., Ariëns, R. A. S., Maurer, M. C., Philippou, H.

“…Essentials The roles of β‐barrels 1 and 2 in factor XIII (FXIII) are currently unknown. FXIII truncations lacking β‐barrel 2, both β‐barrels, or full length…”
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A partially folded state of hen egg white lysozyme in trifluoroethanol: structural characterization and implications for protein folding by Buck, Matthias, Radford, Sheena E, Dobson, Christopher M

“…The effect of 2,2,2-trifluoroethanol (TFE) on the solution conformation of hen egg white lysozyme has been investigated using circular dichroism (CD) and 1H…”
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Conformation of GroEL-bound α-lactalbumin probed by mass spectrometry by Robinson, Carol V, Groß, Michael, Eyles, Stephen J, Ewbank, Jonathan J, Mayhew, Mark, Hartl, F. Ulrich, Dobson, Christopher M, Radford, Sheena E

“…The conformation of a three-disulphide derivative of bovine alpha-lactalbumin bound to the molecular chaperone GroEL has been investigated by monitoring…”
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Thermal unfolding of an intermediate is associated with non-arrhenius kinetics in the folding of hen lysozyme by Matagne, André, Jamin, Marc, Chung, Evonne W., Robinson, Carol V., Radford, Sheena E., Dobson, Christopher M.

“…A variety of techniques, including quenched-flow hydrogen exchange labelling monitored by electrospray ionization mass spectrometry, and stopped-flow…”
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Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis by Xue, Wei-Feng, Homans, Steve W., Radford, Sheena E.

“…Amyloid fibrils are proteinaceous nano-scale linear aggregates. They are of key interest not only because of their association with numerous disorders, such as…”
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Fast and slow tracks in lysozyme folding: insight into the role of domains in the folding process by Matagne, André, Radford, Sheena E., Dobson, Christopher M.

“…The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates…”
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Demonstration by NMR of folding domains in lysozyme by Miranker, Andrew, Radford, Sheena E, Karplus, Martin, Dobson, Christopher M

“…Although there has been much speculation on the pathways of protein folding, only recently have experimental data on the topic been available. The study of…”
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Specific glycosaminoglycans promote unseeded amyloid formation from β2-microglobulin under physiological conditions by Borysik, A.J., Morten, I.J., Radford, S.E., Hewitt, E.W.

“…Dialysis-related amyloidosis (DRA) is a complication of hemodialysis where β2-microglobulin (β2m) forms plaques mainly in cartilaginous tissues. The…”
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Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR by Chung, Evonne W., Nettleton, Ewan J., Morgan, Charles J., Groß, Michael, Miranker, Andrew, Radford, Sheena E., Dobson, Christopher M., Robinson, Carol V.

“…The extent of deuterium labeling of hen lysozyme, its three‐disulfide derivative, and the homologous α‐lactalbumins, has been measured by both mass…”
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