Search Results - "Raderschall, Elke"

Nuclear Foci of Mammalian Recombination Proteins Are Located at Single-Stranded DNA Regions Formed after DNA Damage by Raderschall, Elke, Golub, Efim I., Haaf, Thomas

“…A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals…”
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Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis by Raderschall, Elke, Bazarov, Alex, Cao, Jiangping, Lurz, Rudi, Smith, Avril, Mann, Wolfgang, Ropers, Hans-Hilger, Sedivy, John M, Golub, Efim I, Fritz, Eberhard, Haaf, Thomas

“…After exposure of mammalian cells to DNA damage, the endogenous Rad51 recombination protein is concentrated in multiple discrete foci, which are thought to…”
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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo by Zorn, Emmanuel, Nelson, Erik A., Mohseni, Mehrdad, Porcheray, Fabrice, Kim, Haesook, Litsa, Despina, Bellucci, Roberto, Raderschall, Elke, Canning, Christine, Soiffer, Robert J., Frank, David A., Ritz, Jerome

“…IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3+ regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs…”
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Elevated levels of Rad51 recombination protein in tumor cells by RADERSCHALL, Elke, STOUT, Karen, FREIER, Susanne, SUCKOW, Vanessa, SCHWEIGER, Susann, HAAF, Thomas

“…Rad51 is the key enzyme for homologous recombination, an evolutionarily conserved mechanism for the repair of DNA damage and the generation of genetic…”
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Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors by Batista, Ana, Barata, João T, Raderschall, Elke, Sallan, Stephen E, Carlesso, Nadia, Nadler, Lee M, Cardoso, Angelo A

“…Objective Rationally designed therapies aim at the specific disruption of critical signaling pathways activated by malignant transformation or signals from the…”
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Systematic Genomic Screen for Tyrosine Kinase Mutations in CLL by Brown, Jennifer R., Levine, Ross, Raderschall, Elke, Thompson, Christina, Gilliland, D. Gary, Freedman, Arnold S.

“…Genomic screens have identified activating somatic mutations in tyrosine kinases in a spectrum of acute and chronic hematologic malignancies. These mutations…”
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Prevalence of Familial Lymphoproliferative Malignancy in a Prospectively Screened Cohort of Patients with Lymphoproliferative Disorders by Brown, Jennifer R., Phillips, Kimberly S., Neuberg, Donna, Raderschall, Elke, Freedman, Arnold S.

“…Although an inherited contribution to CLL/SLL and Hodgkin's lymphoma (HL) is increasingly accepted, the contribution of inherited predisposition to…”
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Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei by Haaf, Thomas, Raderschall, Elke, Reddy, Gurucharan, Ward, David C., Radding, Charles M., Golub, Efim I.

“…The mammalian Rad51 protein is involved in homologous recombination and in DNA damage repair. Its nuclear distribution after DNA damage is highly dynamic, and…”
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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells invivo by ZORN, Emmanuel, NELSON, Erik A, FRANK, David A, RITZ, Jerome, MOHSENI, Mehrdad, PORCHERAY, Fabrice, KIM, Haesook, LITSA, Despina, BELLUCCI, Roberto, RADERSCHALL, Elke, CANNING, Christine, SOIFFER, Robert J

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Crystallization and preliminary diffraction studies of 5 S rRNA from the thermophilic bacterium Thermus flavus by Lorenz, S, Betzel, C, Raderschall, E, Dauter, Z, Wilson, K S, Erdmann, V A

“…Crystals of purified 5 S rRNA from Thermus flavus have been obtained. The crystals diffract up to 8 A resolution, using synchrotron radiation, and have the…”
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