Search Results - "Rader, D. J."

High-Density Lipoproteins in the Prevention of Cardiovascular Disease: Changing the Paradigm by Tuteja, S, Rader, D J

“…High‐density‐lipoprotein cholesterol (HDL‐C) has been identified in population studies as an independent inverse predictor of cardiovascular events. Although…”
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Convergence behavior of a new DSMC algorithm by Gallis, M.A., Torczynski, J.R., Rader, D.J., Bird, G.A.

“…The convergence rate of a new direct simulation Monte Carlo (DSMC) method, termed “sophisticated DSMC”, is investigated for one-dimensional Fourier flow. An…”
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Inflammatory Markers of Coronary Risk by Rader, Daniel J

“…The past decade has been characterized by growing interest in the idea that atherosclerosis is an inflammatory disease 1 and by the finding that serum levels…”
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Does nicotinic acid (niacin) lower blood pressure? by Bays, H E, Rader, D J

“…Nicotinic acid (niacin) is a well-established treatment for dyslipidaemia - an important cardiovascular disease (CVD) risk factor. However, niacin may also…”
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The lipid-lowering effects of lomitapide are unaffected by adjunctive apheresis in patients with homozygous familial hypercholesterolaemia – A post-hoc analysis of a Phase 3, single-arm, open-label trial by Stefanutti, C, Blom, D.J, Averna, M.R, Meagher, E.A, Theron, H. dT, Marais, A.D, Hegele, R.A, Sirtori, C.R, Shah, P.K, Gaudet, D, Vigna, G.B, Sachais, B.S, Di Giacomo, S, du Plessis, A.M.E, Bloedon, L.T, Balser, J, Rader, D.J, Cuchel, M

“…Abstract Objective Lomitapide (a microsomal triglyceride transfer protein inhibitor) is an adjunctive treatment for homozygous familial hypercholesterolaemia…”
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Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons by Rumberger, J A, Brundage, B H, Rader, D J, Kondos, G

“…Coronary artery disease is the No. 1 cause of death in the developed world. Effective means of treatment such as drug therapy to lower cholesterol levels are…”
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A novel endothelial-derived lipase that modulates HDL metabolism by Rader, Daniel J, Jaye, Michael, Lynch, Kevin J, Krawiec, John, Marchadier, Dawn, Maugeais, Cyrille, Doan, Kim, South, Victoria, Amin, Dilip, Perrone, Mark

“…High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation…”
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Gene Transfer and Hepatic Overexpression of the HDL Receptor SR-BI Reduces Atherosclerosis in the Cholesterol-Fed LDL Receptor–Deficient Mouse by Kozarsky, Karen F, Donahee, Mary H, Glick, Jane M, Krieger, Monty, Rader, Daniel J

“…ABSTRACTHDL cholesterol levels in humans are inversely correlated with the risk of atherosclerosis. The class B scavenger receptor type I (SR-BI) is the first…”
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Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice by TANGIRALA, R. K, TSUKAMOTO, K, CHUN, S. H, USHER, D, PURE, E, RADER, D. J

“…The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of…”
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Evidence that endothelial lipase remodels high density lipoproteins without mediating the dissociation of apolipoprotein A-I by Jahangiri, A., Rader, D.J., Marchadier, D., Curtiss, L.K., Bonnet, D.J., Rye, K-A.

“…Endothelial lipase (EL) is a triglyceride lipase gene family member that has high phospholipase and low triglyceride lipase activity. The aim of this study was…”
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A new feature on the cholesterol-lowering landscape by Rader, Daniel J

“…Reduction in blood levels of low-density lipoprotein cholesterol reduces the risk of coronary heart disease. The identification of a new class of compounds…”
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Nonzero-Concentration Boundary Condition for Advection-Diffusion Aerosol-Transport Modeling by Gallis, M. A., Torczynski, J. R., Rader, D. J.

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The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice by Daugherty, A, Puré, E, Delfel-Butteiger, D, Chen, S, Leferovich, J, Roselaar, S E, Rader, D J

“…Activated T lymphocytes are present in human atherosclerotic lesions and autoantibodies to antigens within lesions have been detected in serum, but the roles…”
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Deficiency in Inducible Nitric Oxide Synthase Results in Reduced Atherosclerosis in Apolipoprotein E-Deficient Mice by Detmers, Patricia A, Hernandez, Melba, Mudgett, John, Hassing, Heide, Burton, Charlotte, Mundt, Steven, Chun, Sam, Fletcher, Dan, Card, Deborah J, Lisnock, JeanMarie, Weikel, Renee, Bergstrom, James D, Shevell, Diane E, Hermanowski-Vosatka, Anne, Sparrow, Carl P, Chao, Yu-Sheng, Rader, Daniel J, Wright, Samuel D, Pure, Ellen

“…Inducible NO synthase (iNOS) present in human atherosclerotic plaques could contribute to the inflammatory process of plaque development. The role of iNOS in…”
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Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women by Sack, M N, Rader, D J, Cannon, 3rd, R O

“…Oxidative modification of low-density lipoprotein (LDL) may be atherogenic. We studied the time of onset of LDL oxidation (lag) in 18 postmenopausal women…”
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Development and feasibility of quantitative dynamic cardiac imaging for mice using μSPECT by Guerraty, M.A., Johnson, L.C., Blankemeyer, E., Rader, D.J., Moore, S.C., Metzler, S.D.

“…Despite growing interest in coronary microvascular disease (CMVD), there is a dearth of mechanistic understanding. Mouse models offer opportunities to…”
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Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia by Wetterau, John R., Aggerbeck, Lawrence P., Bouma, Marie-Elisabeth, Eisenberg, Claude, Munck, Anne, Hermier, Michel, Schmitz, Jacques, Gay, Gerard, Rader, Daniel J., Gregg, Richard E.

“…Abetalipoproteinemia is a human genetic disease that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and…”
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The α-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible contributor to atherogenesis by Higazi, Abd Al-Roof, Nassar, Taher, Ganz, Tomas, Rader, Daniel J., Udassin, Raphael, Bdeir, Khalil, Hiss, Edna, Sachais, Bruce S., Williams, Kevin Jon, Leitersdorf, Eran, Cines, Douglas B.

“…Inflammation may contribute to the pathogenesis of atherosclerosis. On the basis of previous reports that human atherosclerotic lesions contain α-defensins, a…”
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Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient Mice by Tsukamoto, Kazuhisa, Tangirala, Rajendra, Chun, Sam H, Puré, Ellen, Rader, Daniel J

“…Apolipoprotein E (apoE) is a multifunctional protein synthesized by the liver and tissue macrophages. ApoE-deficient mice have severe hyperlipidemia and…”
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ABC1: connecting yellow tonsils, neuropathy, and very low HDL by Hobbs, H H, Rader, D J

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