Search Results - "Radeke, Monte J"

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration by Lenis, Tamara L., Hu, Jane, Ng, Sze Yin, Jiang, Zhichun, Sarfare, Shanta, Lloyd, Marcia B., Esposito, Nicholas J., Samuel, William, Jaworski, Cynthia, Bok, Dean, Finnemann, Silvia C., Radeke, Monte J., Redmond, T. Michael, Travis, Gabriel H., Radu, Roxana A.

“…Recessive Stargardt disease (STGD1) is an inherited blinding disorder caused by mutations in the Abca4 gene. ABCA4 is a flippase in photoreceptor outer…”
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Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase R by Pfaller, Christian K, Radeke, Monte J, Cattaneo, Roberto, Samuel, Charles E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration by Johnson, Lincoln V, Forest, David L, Banna, Christopher D, Radeke, Carolyn M, Maloney, Michelle A, Hu, Jane, Spencer, Christine N, Walker, Aimee M, Tsie, Marlene S, Bok, Dean, Radeke, Monte J, Anderson, Don H

“…We introduce a human retinal pigmented epithelial (RPE) cell-culture model that mimics several key aspects of early stage age-related macular degeneration…”
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An in vitro model of chronic wounding and its implication for age-related macular degeneration by Bailey-Steinitz, Lindsay J., Shih, Ying-Hsuan, Radeke, Monte J., Coffey, Pete J.

“…Degeneration of the retinal pigment epithelium (RPE) plays a central role in age-related macular degeneration (AMD). Throughout life, RPE cells are challenged…”
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ROCK Inhibition Extends Passage of Pluripotent Stem Cell‐Derived Retinal Pigmented Epithelium by Croze, Roxanne H., Buchholz, David E., Radeke, Monte J., Thi, William J., Hu, Qirui, Coffey, Peter J., Clegg, Dennis O.

“…This research examined the involvement of Rho‐associated, coiled‐coil protein kinase (ROCK) in human embryonic stem cell‐ (hESC) and induced pluripotent stem…”
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The Alzheimer's Aβ-Peptide Is Deposited at Sites of Complement Activation in Pathologic Deposits Associated with Aging and Age-Related Macular Degeneration by Johnson, Lincoln V., Leitner, William P., Rivest, Alexander J., Staples, Michelle K., Radeke, Monte J., Anderson, Don H.

“…Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older individuals worldwide. The disease is characterized by abnormal…”
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Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications by Hageman, Gregory S, Hancox, Lisa S, Taiber, Andrew J, Gehrs, Karen M, Anderson, Don H, Johnson, Lincoln V, Radeke, Monte J, Kavanagh, David, Richards, Anna, Atkinson, John, Meri, Seppo, Bergeron, Julie, Zernant, Jana, Merriam, Joanna, Gold, Bert, Allikmets, Rando, Dean, Michael

“…Variants in the complement factor H gene (CFH) are associated with age-related macular degeneration (AMD). CFH and five CFH-related genes (CFHR1-5) lie within…”
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Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology by Jun, Gyungah, Nicolaou, Michael, Morrison, Margaux A, Buros, Jacqueline, Morgan, Denise J, Radeke, Monte J, Yonekawa, Yoshihiro, Tsironi, Evangelia E, Kotoula, Maria G, Zacharaki, Fani, Mollema, Nissa, Yuan, Yang, Miller, Joan W, Haider, Neena B, Hageman, Gregory S, Kim, Ivana K, Schaumberg, Debra A, Farrer, Lindsay A, DeAngelis, Margaret M

“…ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression…”
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Disease susceptibility of the human macula: Differential gene transcription in the retinal pigmented epithelium/choroid by Radeke, Monte J., Peterson, Katie E., Johnson, Lincoln V., Anderson, Don H.

“…The discoveries of gene variants associated with macular diseases have provided valuable insight into their molecular mechanisms, but they have not clarified…”
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2DE identification of proteins exhibiting turnover and phosphorylation dynamics during sea urchin egg activation by Roux, Michelle M., Radeke, Monte J., Goel, Manisha, Mushegian, Arcady, Foltz, Kathy R.

“…The animal egg is a unique quiescent cell, prepackaged with maternal mRNAs and proteins that have functions in early development. Rapid, transient signaling at…”
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The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited by Anderson, Don H., Radeke, Monte J., Gallo, Natasha B., Chapin, Ethan A., Johnson, Patrick T., Curletti, Christy R., Hancox, Lisa S., Hu, Jane, Ebright, Jessica N., Malek, Goldis, Hauser, Michael A., Bowes Rickman, Catherine, Bok, Dean, Hageman, Gregory S., Johnson, Lincoln V.

“…During the past ten years, dramatic advances have been made in unraveling the biological bases of age-related macular degeneration (AMD), the most common cause…”
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Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration by Radeke, Monte J, Radeke, Carolyn M, Shih, Ying-Hsuan, Hu, Jane, Bok, Dean, Johnson, Lincoln V, Coffey, Pete J

“…Age-related macular degeneration (AMD) is a leading cause of blindness. Most vision loss occurs following the transition from a disease of deposit formation…”
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Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks by Newman, Aaron M, Gallo, Natasha B, Hancox, Lisa S, Miller, Norma J, Radeke, Carolyn M, Maloney, Michelle A, Cooper, James B, Hageman, Gregory S, Anderson, Don H, Johnson, Lincoln V, Radeke, Monte J

“…Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract Age-related macular degeneration (AMD) is a leading cause of blindness…”
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Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration by Liu, Jian, Copland, David A, Clare, Alison J, Gorski, Mathias, Richards, Burt T, Scott, Louis, Theodoropoulou, Sofia, Greferath, Ursula, Cox, Katherine, Shi, Gongyu, Bell, Oliver H, Ou, Kepeng, Powell, Jenna Le Brun, Wu, Jiahui, Robles, Luis Martinez, Li, Yingxin, Nicholson, Lindsay B, Coffey, Peter J, Fletcher, Erica L, Guymer, Robyn, Radeke, Monte J, Heid, Iris M, Hageman, Gregory S, Chan, Ying Kai, Dick, Andrew D

“…Chronic inflammation is a constitutive component of many age-related diseases, including age-related macular degeneration (AMD). Here, we identified…”
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Restoration of Mesenchymal RPE by Transcription Factor-Mediated Reprogramming by Shih, Ying-Hsuan, Radeke, Monte J, Radeke, Carolyn M, Coffey, Pete J

“…Transforming growth factor β-mediated epithelial-to-mesenchymal transition (EMT) is a major component of the wound healing response and a negative determinant…”
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Array-based Discovery of Aptamer Pairs by Cho, Minseon, Oh, Seung Soo, Nie, Jeff, Stewart, Ron, Radeke, Monte J, Eisenstein, Michael, Coffey, Peter J, Thomson, James A, Soh, H. Tom

“…Affinity reagent pairs that recognize distinct epitopes on a target protein can greatly improve the sensitivity and specificity of molecular detection…”
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New Compstatin Peptides Containing N‑Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics by Gorham, Ronald D, Forest, David L, Khoury, George A, Smadbeck, James, Beecher, Consuelo N, Healy, Evangeline D, Tamamis, Phanourios, Archontis, Georgios, Larive, Cynthia K, Floudas, Christodoulos A, Radeke, Monte J, Johnson, Lincoln V, Morikis, Dimitrios

“…Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions;…”
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Gene transfer and molecular cloning of the rat nerve growth factor receptor by Radeke, Monte J, Misko, Thomas P, Hsu, Charles, Herzenberg, Leonard A, Shooter, Eric M

“…The amino-acid sequence of one form of the receptor for nerve growth factor defines a new class of growth factor receptors. Further knowledge of these…”
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Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration by Morrison, Margaux A, Silveira, Alexandra C, Huynh, Nancy, Jun, Gyungah, Smith, Silvia E, Zacharaki, Fani, Sato, Hajime, Loomis, Stephanie, Andreoli, Michael T, Adams, Scott M, Radeke, Monte J, Jelcick, Austin S, Yuan, Yang, Tsiloulis, Aristoteles N, Chatzoulis, Dimitrios Z, Silvestri, Giuliana, Kotoula, Maria G, Tsironi, Evangelia E, Hollis, Bruce W, Chen, Rui, Haider, Neena B, Miller, Joan W, Farrer, Lindsay A, Hageman, Gregory S, Kim, Ivana K, Schaumberg, Debra A, DeAngelis, Margaret M

“…Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous…”
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Immunocytochemical localization of TrkB in the central nervous system of the adult rat by Yan, Qiao, Radeke, Monte J., Matheson, Christine R., Talvenheimo, Jane, Welcher, Andrew A., Felnstein, Stuart C.

“…The TrkB family of transmembrane proteins serve as receptors for brain‐derived neurotrophic factor (BDNF), neurotrophin (NT)‐4/5, and possibly NT‐3, three…”
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