Search Results - "Radecke, Julika"

Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress by Mendonça, Luiza, Howe, Andrew, Gilchrist, James B., Sheng, Yuewen, Sun, Dapeng, Knight, Michael L., Zanetti-Domingues, Laura C., Bateman, Benji, Krebs, Anna-Sophia, Chen, Long, Radecke, Julika, Li, Vivian D., Ni, Tao, Kounatidis, Ilias, Koronfel, Mohamed A., Szynkiewicz, Marta, Harkiolaki, Maria, Martin-Fernandez, Marisa L., James, William, Zhang, Peijun

“…Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However,…”
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Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly by Ni, Tao, Jiang, Qiuyao, Ng, Pei Cing, Shen, Juan, Dou, Hao, Zhu, Yanan, Radecke, Julika, Dykes, Gregory F., Huang, Fang, Liu, Lu-Ning, Zhang, Peijun

“…Carboxysomes are a paradigm of self-assembling proteinaceous organelles found in nature, offering compartmentalisation of enzymes and pathways to enhance…”
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An Improved Method for Growing Primary Neurons on Electron Microscopy Grids Co-Cultured with Astrocytes by Kumar, Ishika, Paudyal, Anju, Kádková, Anna, Stewart, Michelle, Sørensen, Jakob Balslev, Radecke, Julika

“…With the increasing popularity of cryo-electron tomography (cryo-ET) in recent years, the quest to establish a method for growing primary neurons directly on…”
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Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution by Küçükoğlu, Berk, Mohammed, Inayathulla, Guerrero-Ferreira, Ricardo C., Ribet, Stephanie M., Varnavides, Georgios, Leidl, Max Leo, Lau, Kelvin, Nazarov, Sergey, Myasnikov, Alexander, Kube, Massimo, Radecke, Julika, Sachse, Carsten, Müller-Caspary, Knut, Ophus, Colin, Stahlberg, Henning

“…Cryo-transmission electron microscopy (cryo-EM) of frozen hydrated specimens is an efficient method for the structural analysis of purified biological…”
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Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack by Wolfmeier, Heidi, Radecke, Julika, Schoenauer, Roman, Koeffel, René, Babiychuk, Viktoria S., Drücker, Patrick, Hathaway, Lucy J., Mitchell, Timothy J., Zuber, Benoît, Draeger, Annette, Babiychuk, Eduard B.

“…Streptococcus pneumoniae is a potent human pathogen. Its pore-forming exotoxin pneumolysin is instrumental for breaching the host's epithelial barrier and for…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Bas, Audrey Le, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41594-021-00566-w…”
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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiangdong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface by Ni, Tao, Mendonça, Luiza, Zhu, Yanan, Howe, Andrew, Radecke, Julika, Shah, Pranav M., Sheng, Yuewen, Krebs, Anna-Sophia, Duyvesteyn, Helen M.E., Allen, Elizabeth, Lambe, Teresa, Bisset, Cameron, Spencer, Alexandra, Morris, Susan, Stuart, David I., Gilbert, Sarah, Zhang, Peijun

“…Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been proven to be an effective means of decreasing COVID-19 mortality,…”
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The SNAP-25 Protein Family by Kádková, Anna, Radecke, Julika, Sørensen, Jakob B.

“…•We review the expression, function and regulation of the SNAP-25 protein family.•SNAP-25 and SNAP-23 are specialized for regulated exocytosis.•SNAP-25 couples…”
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The antigenic anatomy of SARS-CoV-2 receptor binding domain by Dejnirattisai, Wanwisa, Zhou, Daming, Ginn, Helen M., Duyvesteyn, Helen M.E., Supasa, Piyada, Case, James Brett, Zhao, Yuguang, Walter, Thomas S., Mentzer, Alexander J., Liu, Chang, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Kafai, Natasha M., Bailey, Adam L., Chen, Rita E., Ying, Baoling, Thompson, Craig, Bolton, Jai, Fyfe, Alex, Gupta, Sunetra, Tan, Tiong Kit, Gilbert-Jaramillo, Javier, James, William, Knight, Michael, Carroll, Miles W., Skelly, Donal, Dold, Christina, Peng, Yanchun, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Temperton, Nigel, Hall, David R., Williams, Mark A., Paterson, Neil G., Bertram, Felicity K.R., Siebert, C. Alistair, Clare, Daniel K., Howe, Andrew, Radecke, Julika, Song, Yun, Townsend, Alain R., Huang, Kuan-Ying A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Diamond, Michael S., Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies…”
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CryoVesNet: A dedicated framework for synaptic vesicle segmentation in cryo-electron tomograms by Khosrozadeh, Amin, Seeger, Raphaela, Witz, Guillaume, Radecke, Julika, Sørensen, Jakob B, Zuber, Benoît

“…Cryo-electron tomography (cryo-ET) has the potential to reveal cell structure down to atomic resolution. Nevertheless, cellular cryo-ET data is highly complex,…”
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Cryo-electron Tomography Remote Data Collection and Subtomogram Averaging by Sheng, Yuewen, Morris, Kyle, Radecke, Julika, Zhang, Peijun

“…Cryo-electron tomography (cryo-ET) has been gaining momentum in recent years, especially since the introduction of direct electron detectors, improved…”
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient by Zhou, Daming, Duyvesteyn, Helen M. E., Chen, Cheng-Pin, Huang, Chung-Guei, Chen, Ting-Hua, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Ma, Che, Huo, Jiandong, Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N. M., Tan, Tiong Kit, Rijal, Pramila, Donat, Robert F., Godwin, Kerry, Buttigieg, Karen R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles W., Gilbert-Jaramillo, Javier, Knight, Michael L., James, William, Owens, Raymond J., Naismith, James H., Townsend, Alain R., Fry, Elizabeth E., Zhao, Yuguang, Ren, Jingshan, Stuart, David I., Huang, Kuan-Ying A.

“…The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A,…”
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Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ by Stucki, David M., Ruegsegger, Céline, Steiner, Silvio, Radecke, Julika, Murphy, Michael P., Zuber, Benoît, Saxena, Smita

“…Spinocerebellar ataxia type 1 (SCA1), due to an unstable polyglutamine expansion within the ubiquitously expressed Ataxin-1 protein, leads to the premature…”
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Morphofunctional changes at the active zone during synaptic vesicle exocytosis by Radecke, Julika, Seeger, Raphaela, Kádková, Anna, Laugks, Ulrike, Khosrozadeh, Amin, Goldie, Kenneth N, Lučić, Vladan, Sørensen, Jakob B, Zuber, Benoît

“…Synaptic vesicle (SV) fusion with the plasma membrane (PM) proceeds through intermediate steps that remain poorly resolved. The effect of persistent high or…”
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Characterization of the rotavirus assembly pathway in situ using cryoelectron tomography by Shah, Pranav N.M., Gilchrist, James B., Forsberg, Björn O., Burt, Alister, Howe, Andrew, Mosalaganti, Shyamal, Wan, William, Radecke, Julika, Chaban, Yuriy, Sutton, Geoff, Stuart, David I., Boyce, Mark

“…Rotavirus assembly is a complex process that involves the stepwise acquisition of protein layers in distinct intracellular locations to form the fully…”
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Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology by Ruegsegger, Céline, Stucki, David M., Steiner, Silvio, Angliker, Nico, Radecke, Julika, Keller, Eva, Zuber, Benoît, Rüegg, Markus A., Saxena, Smita

“…Spinocerebellar ataxia type 1 (SCA1), due to the expansion of a polyglutamine repeat within the ubiquitously expressed Ataxin-1 protein, leads to the premature…”
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