Search Results - "Raddad, E."

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes by Kelly, R. P., Garhyan, P., Raddad, E., Fu, H., Lim, C. N., Prince, M. J., Pinaire, J. A., Loh, M. T., Deeg, M. A.

“…Aim To describe the clinical effects of single and multiple doses of a potent, selective, orally administered, small‐molecule antagonist of the human glucagon…”
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CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial by Jin, Y., Smith, C., Monteith, D., Brown, R., Camporeale, A., McNearney, T.A., Deeg, M.A., Raddad, E., Xiao, N., de la Peña, A., Kivitz, A.J., Schnitzer, T.J.

“…This study tested whether galcanezumab, a humanized monoclonal antibody with efficacy against migraine, was superior to placebo for the treatment of mild or…”
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Applications of Bayesian statistical methodology to success criteria: A case study of a phase 2 design with interim futility assessment in patients with knee osteoarthritis by Smith, C, Jin, Y, Raddad, E, McNearney, T, Ni, X, Monteith, D, Brown, R, Deeg, M, Schnitzer, T

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LY2951742, a monoclonal antibody against CGRP, failed to reduce signs and symptoms of knee osteoarthritis by Jin, Y, Smith, C, Monteith, D, Brown, R, Camporeale, A, McNearney, T, Deeg, M, Raddad, E, de la Pena, A, Kivitz, A, Schnitzer, T

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The influence of different Acacia senegal agroforestry systems on soil water and crop yields in clay soils of the Blue Nile region, Sudan by Raddad, E.Y., Luukkanen, O.

“…The purpose of this study was to test the hypotheses that (1) the tree Acacia senegal competes for water with associated agricultural crops, and the soil water…”
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Population Pharmacokinetic and Pharmacodynamic Modeling of LY2510924 in Patients With Advanced Cancer by Bihorel, S, Raddad, E, Fiedler‐Kelly, J, Stille, JR, Hing, J, Ludwig, E

“…The objectives of this study were to characterize the pharmacokinetics (PK) of LY2510924, a potent peptide antagonist of the CXCR4 receptor, after subcutaneous…”
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Productivity and nutrient cycling in young Acacia senegal farming systems on Vertisol in the Blue Nile region, Sudan by Raddad, E.Y, Luukkanen, O, Salih, A.A, Kaarakka, V, Elfadl, MA

“…Acacia senegal, the gum arabic-producing tree, is the most important component of traditional dryland agroforestry systems in theSudan. The spatial arrangement…”
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Pharmacometric Analyses to Support Early Development Decisions for LY2878735: A Novel Serotonin Norepinephrine Reuptake Inhibitor by Raddad, E, Melhem, MR, Sloan‐Lancaster, JS, Miller, JW, Van Wart, SA, Rubino, CM

“…LY2878735 is a novel dual serotonin (5‐hydroxytryptamine (5‐HT)) and norepinephrine (NE) reuptake inhibitor (SNRI) in development for chronic pain indications…”
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A decade of innovation in pharmaceutical R&D: the Chorus model by Owens, Paul K., Raddad, Eyas, Miller, Jeffrey W., Stille, John R., Olovich, Kenneth G., Smith, Neil V., Jones, Rosie S., Scherer, Joel C.

“…Chorus is a small, operationally independent organization within Eli Lilly and Company that specializes in drug development from candidate selection through to…”
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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects by Raddad, Eyas, Chappell, Amy, Meyer, Jeffery, Wilson, Alan, Ruegg, Charles E, Tauscher, Johannes, Statnick, Michael A, Barth, Vanessa, Zhang, Xin, Verfaille, Steven J

“…Therapeutic benefits from nociceptin opioid peptide receptor (NOP) antagonism were proposed for obesity, eating disorders, and depression. LY2940094…”
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Application of nonlinear mixed effects modeling in allometric interspecies scaling of emtricitabine by Abu‐Raddad, E., Boudinot, F.D.

“…Background/Aims Allometry successfully predicted human pharmacokinetic (PK) properties of nucleoside analogues due to efficient renal excretion and low plasma…”
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Clinical Pharmacokinetics of Alamifovir and Its Metabolites by CHAN, Clark, ABU-RADDAD, Eyas, WISE, Stephen D, GOLOR, Georg, WATANABE, Hikari, SASAKI, Akira, KWEE POO YEO, SOON, Danny, SINHA, Vikram P, FLANAGAN, Shawn D, HE, Minxia M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Adaptive genetic variation in water-use efficiency and gum yield in Acacia senegal provenances grown on clay soil in the Blue Nile region, Sudan by Raddad, El Amin Y., Luukkanen, Olavi

“…The genetic variation in shoot growth, water-use efficiency (as assessed by δ 13C) and gum production was compared among eight Acacia senegal provenances…”
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Chiral Capillary Electrophoretic Determination of 2′,3′-Dideoxy-5-fluoro-3′-thiacytidine in Rat Plasma by Delinsky, David C., Abu-Raddad, Eyas J., Bartlett, Michael G.

“…Chiral drugs have the potential for differential pharmacokinetics and metabolism of individual enantiomers. Analytical methods are needed for the separation…”
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